INT121000

Context Info Confidence 0.13 First Reported 2004 Last Reported 2004 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.67 Pain Relevance 1.25

nuclear envelope (Nrm) signal transduction (PAG1) nucleus (Nrm) plasma membrane (PAG1) intracellular (PAG1)

Anatomy Link Frequency spinal cord 1 PAG1 (Homo sapiens) Nrm (Rattus norvegicus)

Pain Link Frequency Relevance Heat Raphe magnus 3 100.00 Spinal cord 2 99.64 cINOD 6 99.20 Central grey 1 96.04 Pain 2 94.12 Analgesic 4 86.80 aspirin 3 82.40 tolerance 7 75.00 Opioid 2 75.00 tail-flick 1 73.60

Disease Link Frequency Relevance Heat Urological Neuroanatomy 7 100.00 Pain 2 94.12 INFLAMMATION 1 88.44 Opiate Addiction 2 25.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The NSAID dipyrone (metamizol) has been shown to engage opioidergic circuits at the PAG, the NRM and the spinal cord, but it is unknown whether this can be generalized to typical NSAIDs and to systemic administration.

PAG Binding (engage) of NRM in spinal cord associated with raphe magnus, cinod, urological neuroanatomy and spinal cord

1) Confidence 0.13 Published 2004 Journal Pain Section Abstract Doc Link 15327823 Disease Relevance 0.67 Pain Relevance 1.25

General Comments

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