INT121435

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Context Info
Confidence 0.43
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.82
Pain Relevance 2.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (P2rx1) plasma membrane (P2rx1) protein complex (P2rx1)
Anatomy Link Frequency
neuronal 2
P2rx1 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 18 100.00 Very High Very High Very High
antagonist 5 100.00 Very High Very High Very High
nMDA receptor antagonist 1 100.00 Very High Very High Very High
Spinal cord 10 99.44 Very High Very High Very High
Brush evoked pain 8 99.32 Very High Very High Very High
Thermal hyperalgesia 4 94.40 High High
qutenza 4 90.64 High High
Pain 3 86.44 High High
intrathecal 1 84.92 Quite High
Central nervous system 18 79.52 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 10 99.32 Very High Very High Very High
Targeted Disruption 5 94.80 High High
Hyperalgesia 4 94.40 High High
Nociception 5 88.84 High High
Pain 3 86.44 High High
Headache 1 76.40 Quite High
INFLAMMATION 2 75.12 Quite High
Cv Unclassified Under Development 5 5.00 Very Low Very Low Very Low
Ganglion Cysts 4 5.00 Very Low Very Low Very Low
Coronary Heart Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Preceding intramuscular administration of the P2X receptor antagonist PPADS (3-100 nmol/l) suppressed the ATP effect.
Negative_regulation (suppressed) of Gene_expression (administration) of P2X receptor associated with antagonist
1) Confidence 0.43 Published 2006 Journal Cephalalgia Section Abstract Doc Link 16686909 Disease Relevance 0.41 Pain Relevance 0.28
ATP P2X receptor antagonists, pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid and 2',3'-O-(2,4,6-trinitrophenyl)adenosine 5-triphosphate, NMDA receptor antagonist, MK 801 and nitric oxide synthetase inhibitor, 7-nitroindazole blocked the PAF-induced tactile allodynia.
Negative_regulation (blocked) of Gene_expression (antagonists) of P2X receptor associated with brush evoked pain, nmda receptor antagonist, adenocard and antagonist
2) Confidence 0.14 Published 2004 Journal Pain Section Abstract Doc Link 15363879 Disease Relevance 1.32 Pain Relevance 1.87
The distribution of P2X receptors in neuronal structures
Negative_regulation (distribution) of Gene_expression (receptors) of P2X in neuronal
3) Confidence 0.09 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072919 Disease Relevance 0.09 Pain Relevance 0.06

General Comments

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