INT121608

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Context Info
Confidence 0.15
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 23
Total Number 23
Disease Relevance 9.35
Pain Relevance 4.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Prkag1) nucleus (Prkag1) protein complex (Prkag1)
response to stress (Prkag1)
Anatomy Link Frequency
hypothalamus 1
liver 1
glial cells 1
bands 1
adipocytes 1
Prkag1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 6 100.00 Very High Very High Very High
Inflammation 499 99.62 Very High Very High Very High
Morphine 8 99.44 Very High Very High Very High
Inflammatory response 101 99.24 Very High Very High Very High
qutenza 8 98.64 Very High Very High Very High
cytokine 619 96.88 Very High Very High Very High
Inflammatory mediators 160 93.60 High High
adenocard 19 91.40 High High
Multiple sclerosis 14 78.64 Quite High
amygdala 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Insulin Resistance 69 100.00 Very High Very High Very High
INFLAMMATION 775 99.62 Very High Very High Very High
Increased Venous Pressure Under Development 2 99.44 Very High Very High Very High
Obesity 22 99.16 Very High Very High Very High
Disease 519 98.00 Very High Very High Very High
Body Weight 88 97.16 Very High Very High Very High
Breast Cancer 2 97.04 Very High Very High Very High
Stress 202 96.52 Very High Very High Very High
Toxicity 100 92.56 High High
Neurological Disease 42 91.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AMPK activation by genistein in combination with capsaicin is critical for inhibiting COX-2.
Positive_regulation (activation) of AMPK associated with qutenza
1) Confidence 0.15 Published 2009 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 19723084 Disease Relevance 0.79 Pain Relevance 0.90
However, at present it is not clear how the activation of AMP kinase cascade would mediate reduced activation of the MAP kinases.


Positive_regulation (activation) of AMP kinase
2) Confidence 0.09 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1262754 Disease Relevance 0.06 Pain Relevance 0.14
Additionally, acute as well as chronic intraperitoneal morphine administration changed the abundance of PKC gamma, gamma1 subunit of GABAA and hsp70 genes.
Positive_regulation (abundance) of gamma1 subunit associated with kinase c and morphine
3) Confidence 0.08 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15379885 Disease Relevance 0.08 Pain Relevance 0.64
We previously reported that AICAR mediates its effects via activation of AMPK and that activated AMPK downregulates pro-inflammatory responses by downregulation of the IKK cascades [19].
Positive_regulation (activation) of AMPK associated with inflammatory response
4) Confidence 0.06 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1262754 Disease Relevance 0.10 Pain Relevance 0.08
Inside the cell (in vivo) AICAR is converted to ZMP (an analog of AMP) which activates AMP kinase kinase (AMPKK) which in turn activates AMP kinase (AMPK) by phosphorylation on residues Thr 172 of the ?
Positive_regulation (activates) of AMPK
5) Confidence 0.06 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1262754 Disease Relevance 0.09 Pain Relevance 0.11
These observations indicate that AICAR activation of AMP kinase by phosphorylation of its catalytic subunits (Thr-172 of ?
Positive_regulation (activation) of AMP kinase
6) Confidence 0.06 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1262754 Disease Relevance 0.07 Pain Relevance 0.13
This protection of neurite growth may in part be mediated via the energy-(ATP) saving mechanisms of AMPK since activation of AMPK is known to shut or slow energy consuming reactions in the cell [16].
Positive_regulation (activation) of AMPK in neurite
7) Confidence 0.06 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1262754 Disease Relevance 0.74 Pain Relevance 0.36
AMPK is known to regulate glucose transport [47] and its metabolism [48], lower blood pressure, boost liver insulin action [49], ameliorate insulin resistance induced by free fatty acids [18], and regulate protein synthesis [50] and forkhead transcription factor FKHR (FOXO1a) [51].
Positive_regulation (induced) of AMPK in liver associated with insulin resistance
8) Confidence 0.06 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1262754 Disease Relevance 1.31 Pain Relevance 0.35
We previously reported that AICAR mediates its effects via activation of AMPK and that activated AMPK downregulates pro-inflammatory responses by downregulation of the IKK cascades [19].
Positive_regulation (activated) of AMPK associated with inflammatory response
9) Confidence 0.06 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1262754 Disease Relevance 0.10 Pain Relevance 0.08
We have earlier reported on the anti-inflammatory role of AICAR via activation of AMPK in quenching LPS-induced pro-inflammatory responses by blockade of MAP kinase and IKK ?
Positive_regulation (activation) of AMPK associated with inflammatory response and inflammation
10) Confidence 0.06 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1262754 Disease Relevance 0.80 Pain Relevance 0.31
Inside the cell (in vivo) AICAR is converted to ZMP (an analog of AMP) which activates AMP kinase kinase (AMPKK) which in turn activates AMP kinase (AMPK) by phosphorylation on residues Thr 172 of the ?
Positive_regulation (activates) of AMP kinase
11) Confidence 0.06 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1262754 Disease Relevance 0.09 Pain Relevance 0.11
AICAR treatment of glial cells activated AMPK as evident from the enhanced intensities of the phospho-specific protein bands of this AMPK at Ser-108 and Thr-172 (Fig. 8B and 8C).
Positive_regulation (activated) of AMPK in bands
12) Confidence 0.06 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1262754 Disease Relevance 0.09 Pain Relevance 0.12
AMP-activated protein kinase [14] (AMPK) is a member of the family of serine/threonine kinases and is activated by cellular increases in AMP concentrations under conditions of nutritional/metabolic stress [15].
Positive_regulation (activated) of AMPK associated with stress
13) Confidence 0.05 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1262754 Disease Relevance 1.13 Pain Relevance 0.21
Inside the cell (in vivo) AICAR is converted to ZMP (an analog of AMP) which activates AMP kinase kinase (AMPKK) which in turn activates AMP kinase (AMPK) by phosphorylation on residues Thr 172 of the ?
Positive_regulation (activates) of AMP kinase
14) Confidence 0.05 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1262754 Disease Relevance 0.09 Pain Relevance 0.11
AICAR is also reported to activate AMPK in the cell following its conversion to ZMP (a non-degradable AMP analog) and thus mimics the activity of AMP for activation of AMPK [18].
Positive_regulation (activation) of AMPK
15) Confidence 0.05 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1262754 Disease Relevance 0.96 Pain Relevance 0.27
Recently, we reported anti-inflammatory properties of AICAR through activation of AMPK [19] in glial cells.
Positive_regulation (activation) of AMPK in glial cells associated with inflammation
16) Confidence 0.05 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1262754 Disease Relevance 0.90 Pain Relevance 0.33
They proposed that resveratrol induced food intake by activating AMPK via Sirt1 activation in the hypothalamus.
Positive_regulation (activating) of AMPK in hypothalamus
17) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.08 Pain Relevance 0
Although LKB1 and AMPK have become attractive therapeutic targets for vascular diseases, the functions of LKB1 and AMPK activation are still not fully understood.
Positive_regulation (activation) of AMPK associated with increased venous pressure under development
18) Confidence 0.04 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 0.50 Pain Relevance 0
Resveratrol is also an activator of AMPK [42], which at the central level positively regulates food intake and body weight gain.
Positive_regulation (activator) of AMPK in body associated with body weight
19) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.27 Pain Relevance 0
In response to AMPK activation the cell decreases ATP-consuming and increases ATP-producing pathways, thus a potential metabolic sensor for the cell (Hardie et al 1998).
Positive_regulation (activation) of AMPK
20) Confidence 0.01 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291335 Disease Relevance 0.07 Pain Relevance 0

General Comments

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