INT121677

Context Info Confidence 0.59 First Reported 2001 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 6 Total Number 13 Disease Relevance 3.15 Pain Relevance 1.61

kinase activity (Srms)

Anatomy Link Frequency neck 2 anal canal 1 Srms (Mus musculus)

Pain Link Frequency Relevance Heat Kinase C 18 100.00 Pain 170 98.36 shoulder pain 64 96.16 Tendonitis 16 95.36 agonist 3 69.32 rheumatoid arthritis 24 58.48 Inflammation 12 50.00 Morphine 4 50.00 Cancer pain 3 50.00 transdermal 2 50.00

Disease Link Frequency Relevance Heat Pathologic Constriction 152 99.98 Targeted Disruption 1 99.98 Pain 160 98.36 Sprains And Strains 26 97.12 Shoulder Pain 64 96.16 Tendinopathy 16 95.36 Rheumatoid Arthritis 24 58.48 Anal Fistula 6 58.32 Cancer Pain 3 50.00 Cancer 1 50.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The main finding from this study shows that the computer users had significantly higher prevalence of SRMS than the non computer users over the past 7 days and during the past 12 months.

Gene_expression (prevalence) of SRMS

1) Confidence 0.59 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2927507 Disease Relevance 0.06 Pain Relevance 0.06

The higher prevalence of SRMS in the computer users may result from one or combination of factors including posture, work tasks, furniture and positioning of the computers relative to the users.

Gene_expression (prevalence) of SRMS

2) Confidence 0.59 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2927507 Disease Relevance 0.08 Pain Relevance 0.08

Conversely the higher prevalence of SRMS of about ninety out of a hundred computer users during the past 12 month could be indicating that most of them had reported one musculoskeletal symptom or the other during the last 12 months.

Gene_expression (prevalence) of SRMS

3) Confidence 0.59 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2927507 Disease Relevance 0 Pain Relevance 0

Considering the anatomical distribution of SRMS over the past 7 days only, computer users had most of their SRMS around the neck while in the non computer users it was at the low back.

Gene_expression (distribution) of SRMS in neck

4) Confidence 0.59 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2927507 Disease Relevance 0.34 Pain Relevance 0.24

Considering the anatomical distribution of SRMS over the past 7 days only, computer users had most of their SRMS around the neck while in the non computer users it was at the low back.

Gene_expression (distribution) of SRMS in neck

5) Confidence 0.59 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2927507 Disease Relevance 0.28 Pain Relevance 0.19

The difference in the prevalence of SRMS during the past 12 months between the computer and the non computer users was significant as well (?

Gene_expression (prevalence) of SRMS

6) Confidence 0.59 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2927507 Disease Relevance 0 Pain Relevance 0

So the essential question should be addressed, what to do with anal canal stenosis following SRM?

Gene_expression (following) of SRM in anal canal associated with pathologic constriction

7) Confidence 0.58 Published 2004 Journal BMC Surg Section Body Doc Link PMC420246 Disease Relevance 0.92 Pain Relevance 0.17

All patients underwent SRM (Table 2).

Gene_expression (underwent) of SRM

8) Confidence 0.58 Published 2004 Journal BMC Surg Section Body Doc Link PMC420246 Disease Relevance 0.70 Pain Relevance 0

Despite the increasing number of computer users and the abundance of evidence suggesting that SRMS are present in computer users, there are very few readily available and conclusive studies that have compared these prevalence with that of the non computer users.

Gene_expression (present) of SRMS

9) Confidence 0.53 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2927507 Disease Relevance 0.28 Pain Relevance 0.28

The SRMS were present if a respondent answered "yes" to the questions and ruled out if the respondent answered "no".

Gene_expression (present) of SRMS

10) Confidence 0.53 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2927507 Disease Relevance 0.33 Pain Relevance 0.26

RESULTS: Pooled efficacy data were available from 1220 patients; these showed that both TDF and SRM were effective in improving pain 'right now' scores (0-100 scale) from baseline to Day 28.

Gene_expression (effective) of SRM

11) Confidence 0.02 Published 2004 Journal Curr Med Res Opin Section Body Doc Link 15383190 Disease Relevance 0 Pain Relevance 0

Indeed, recently we have shown that in a transgenic mouse expressing mutant troponin I lacking protein kinase C phosphorylation sites that during high perfusate calcium inotropy that there is a significant elevation in the ratio of developed pressure to myocardial oxygen consumption relative to wild type controls [13].

Gene_expression (expressing) of sites associated with targeted disruption and kinase c

12) Confidence 0.02 Published 2001 Journal BMC Physiol Section Body Doc Link PMC55339 Disease Relevance 0.10 Pain Relevance 0.31

The ES and SRM express change in terms of the standard deviation and provide a useful indication of the relative sample sizes required to detect statistically significant difference between groups [39].

Gene_expression (express) of SRM

13) Confidence 0.01 Published 2009 Journal Qual Life Res Section Body Doc Link PMC2761817 Disease Relevance 0.06 Pain Relevance 0.03

General Comments

This test has worked.