INT121745

Context Info Confidence 0.04 First Reported 2004 Last Reported 2004 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.87

plasma membrane (Tacr1, Ephb1) cytoplasm (Tacr1, Ephb1) endosome (Ephb1) signal transduction (Ephb1) response to stress (Tacr1) signal transducer activity (Tacr1)

Tacr1 (Rattus norvegicus) Ephb1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Glutamate receptor 1 100.00 Dorsal horn neuron 6 99.76 qutenza 5 95.48 c fibre 6 93.44 central sensitization 4 90.00 Kinase C 1 75.00 Spinal cord 1 60.96 intrathecal 2 25.00 Pain 1 25.00 allodynia 1 25.00

Disease Link Frequency Relevance Heat Pain 1 25.00 Hypersensitivity 1 25.00 Neuropathic Pain 1 25.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The pERK induction is reduced by blockade of NMDA, AMPA/kainate, group I metabotropic glutamate receptor, neurokinin-1, and tyrosine receptor kinase receptors.

neurokinin-1 Negative_regulation (reduced) of Positive_regulation (induction) of pERK associated with glutamate receptor

1) Confidence 0.04 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15385614 Disease Relevance 0 Pain Relevance 0.87

General Comments

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