INT121783

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Context Info
Confidence 0.70
First Reported 2004
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 30
Total Number 30
Disease Relevance 29.22
Pain Relevance 13.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Arc) plasma membrane (Arc) cytoskeleton (Arc)
cytoskeleton organization (Arc) cytoplasm (Arc)
Anatomy Link Frequency
neurons 18
spinal cord 8
dorsal horn 4
dentate gyrus 2
brain 2
Arc (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 1 100.00 Very High Very High Very High
Morphine 34 99.98 Very High Very High Very High
bDMF 288 99.86 Very High Very High Very High
Spinal cord 406 99.68 Very High Very High Very High
Dorsal horn 194 99.68 Very High Very High Very High
Pain 342 99.52 Very High Very High Very High
Enkephalin 146 99.52 Very High Very High Very High
nociceptor 19 99.52 Very High Very High Very High
intrathecal 160 98.80 Very High Very High Very High
Dorsal horn neuron 96 98.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 2775 100.00 Very High Very High Very High
Nociception 659 100.00 Very High Very High Very High
Pain 451 99.50 Very High Very High Very High
Neuroblastoma 2 98.56 Very High Very High Very High
Cognitive Disorder 21 95.60 Very High Very High Very High
Inflammatory Pain 65 95.00 High High
Targeted Disruption 551 94.72 High High
Congenital Anomalies 32 84.88 Quite High
INFLAMMATION 80 75.60 Quite High
Neuropathic Pain 112 38.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine activates Arc expression in the mouse striatum and in mouse neuroblastoma Neuro2A MOR1A cells expressing mu-opioid receptors.
Positive_regulation (activates) of Gene_expression (expression) of Arc in striatum associated with neuroblastoma, aids-related complex, mu opioid receptor and morphine
1) Confidence 0.70 Published 2005 Journal J. Neurosci. Res. Section Title Doc Link 16211563 Disease Relevance 0.71 Pain Relevance 0.87
Inhibition experiments revealed that morphine induced Arc expression in Neuro2A MOR1A cells via intracellular signaling pathways involving mitogen-activated protein (MAP) kinases and protein kinase C.
Positive_regulation (induced) of Gene_expression (expression) of Arc associated with kinase c, aids-related complex and morphine
2) Confidence 0.70 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 16211563 Disease Relevance 0.87 Pain Relevance 1.27
Expression of Arc/Arg3.1 mRNA following nociceptive stimulation occurs in a subset of c-Fos labeled neurons and is intensity dependent
Positive_regulation (dependent) of Gene_expression (Expression) of Arc/Arg3.1 mRNA in neurons associated with nociception and aids-related complex
3) Confidence 0.54 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 1.02 Pain Relevance 0.22
Expression of Arc/Arg3.1 mRNA following nociceptive stimulation occurs in a subset of c-Fos labeled neurons and is intensity dependent
Positive_regulation (occurs) of Gene_expression (Expression) of Arc/Arg3.1 mRNA in neurons associated with nociception and aids-related complex
4) Confidence 0.54 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 1.00 Pain Relevance 0.22
This assumption is in line with our finding that Arc/Arg3.1 expression is intensity dependent.
Positive_regulation (dependent) of Gene_expression (expression) of Arc/Arg3.1 associated with aids-related complex
5) Confidence 0.54 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 1.44 Pain Relevance 0.53
The same study showed a significantly enhanced expression of Arc/Arg3.1 mRNA when NBQX, a potent AMPA receptor blocker, was applied together with BDNF.
Positive_regulation (enhanced) of Gene_expression (expression) of Arc/Arg3.1 mRNA associated with aids-related complex and bdmf
6) Confidence 0.54 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 1.23 Pain Relevance 0.81
Finally, increased expression of Arc may play a role in reducing AMPA receptor-mediated synaptic transmission [69,70].
Positive_regulation (increased) of Gene_expression (expression) of Arc associated with aids-related complex
7) Confidence 0.54 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0.18 Pain Relevance 0.15
In addition, we find substantial and sustained increases in ARC Kiss1 expression at pubertal ages in both hpg females and males in the absence of reproductive hormones (Fig. 5).
Positive_regulation (increases) of Gene_expression (expression) of ARC associated with aids-related complex
8) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912854 Disease Relevance 0.49 Pain Relevance 0
Based on earlier studies that described ARC kisspeptin neurons as mediators of sex steroid negative feedback [9], [10], it was predicted that ARC Kiss1 expression would be increased in hpg mice.
Positive_regulation (increased) of Gene_expression (expression) of ARC in neurons associated with aids-related complex
9) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912854 Disease Relevance 0.93 Pain Relevance 0
However, in the present study a significant increase in the number of Arc/Arg3.1 mRNA expressing neurons could not be confirmed after intrathecal injection of BDNF and NBQX together.
Positive_regulation (increase) of Gene_expression (expressing) of Arc/Arg3.1 mRNA in neurons associated with aids-related complex, bdmf and intrathecal
10) Confidence 0.39 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 1.32 Pain Relevance 0.93
The number of neurons expressing the neuronal activation marker c-Fos or Arc/Arg3.1 mRNA was counted in separate sections treated with IHC or ISH, respectively. c-Fos labeled neurons outnumbered Arc/Arg3.1 mRNA labeled neurons (Fig. 3A), except after 2 hrs mustard oil stimulation when about equal number of neurons were labeled.
Neg (except) Positive_regulation (outnumbered) of Neg (except) Gene_expression (outnumbered) of Arc/Arg3.1 mRNA in neurons associated with aids-related complex
11) Confidence 0.39 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 0.88 Pain Relevance 0.16
The number of neurons expressing the neuronal activation marker c-Fos or Arc/Arg3.1 mRNA was counted in separate sections treated with IHC or ISH, respectively. c-Fos labeled neurons outnumbered Arc/Arg3.1 mRNA labeled neurons (Fig. 3A), except after 2 hrs mustard oil stimulation when about equal number of neurons were labeled.
Positive_regulation (activation) of Gene_expression (expressing) of Arc/Arg3.1 mRNA in neurons associated with aids-related complex
12) Confidence 0.39 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 1.00 Pain Relevance 0.20
The number of neurons producing Arc/Arg3.1 mRNA varied in the different pain models, and increasing the intensity of the pain stimulus resulted in an increased number of neurons expressing Arc/Arg3.1 as shown in the mustard oil experiments.
Positive_regulation (increased) of Gene_expression (expressing) of Arc/Arg3.1 in neurons associated with pain and aids-related complex
13) Confidence 0.39 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 1.31 Pain Relevance 0.88
Peak PER2::LUC expression in the whole Arc was observed 28.6 ± 0.3 h after cull.
Positive_regulation (Peak) of Gene_expression (expression) of Arc associated with aids-related complex
14) Confidence 0.39 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 1.24 Pain Relevance 0
Several types of nociceptive stimuli applied to the hind paw induced Arc/Arg3.1 mRNA expressing neurons on the ipsilateral side (Fig. 2) but not on the contralateral side of the lumbar superficial dorsal horn.
Positive_regulation (induced) of Neg (not) Gene_expression (expressing) of Arc/Arg3.1 mRNA in neurons associated with nociception, aids-related complex and dorsal horn
15) Confidence 0.36 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 0.89 Pain Relevance 0.27
Intrathecal injection of vehicle (n = 2) or NBQX (n = 2) alone did not induce Arc/Arg3.1 mRNA expression in the spinal cord.
Neg (not) Positive_regulation (induce) of Gene_expression (expression) of Arc/Arg3.1 mRNA in spinal cord associated with aids-related complex, spinal cord and intrathecal
16) Confidence 0.36 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 1.33 Pain Relevance 0.78
Nociceptive stimulation induces expression of Arc/Arg3.1 in the spinal cord with a preference for neurons containing enkephalin

Background

Positive_regulation (induces) of Gene_expression (expression) of Arc/Arg3.1 in spinal cord associated with nociception, aids-related complex, enkephalin and spinal cord
17) Confidence 0.36 Published 2010 Journal Mol Pain Section Title Doc Link PMC2920254 Disease Relevance 1.28 Pain Relevance 0.66
Intrathecal injection of brain derived neurotrophic factor (BDNF) also induced expression of Arc/Arg3.1.
Positive_regulation (induced) of Gene_expression (expression) of Arc/Arg3.1 in brain associated with aids-related complex, bdmf and intrathecal
18) Confidence 0.36 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2920254 Disease Relevance 1.70 Pain Relevance 0.78
Expression of Arc/Arg3.1 was induced in an intensity dependent manner in neurons that were located in laminae I (14%) and II (85%) of the spinal dorsal horn.
Positive_regulation (induced) of Gene_expression (Expression) of Arc/Arg3.1 in dorsal horn associated with aids-related complex and spinal dorsal horn
19) Confidence 0.36 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2920254 Disease Relevance 1.51 Pain Relevance 0.73
Furthermore, we found that intrathecal injection with NMDA (n = 2), which served as a positive control, also induced Arc/Arg3.1 expression in the dorsal horn (not shown).


Positive_regulation (induced) of Gene_expression (expression) of Arc/Arg3.1 in dorsal horn associated with aids-related complex, dorsal horn and intrathecal
20) Confidence 0.36 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 1.53 Pain Relevance 0.80

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