INT121784

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Context Info
Confidence 0.38
First Reported 2003
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.68
Pain Relevance 1.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fas) extracellular region (Fas) plasma membrane (Fas)
nucleus (Fas) cytoplasm (Fas)
Anatomy Link Frequency
liver 4
B-cell 2
brains 2
Fas (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 5 99.36 Very High Very High Very High
Paracetamol 11 98.28 Very High Very High Very High
Morphine 3 92.32 High High
opioid receptor 4 90.52 High High
antagonist 3 88.08 High High
narcan 3 86.00 High High
cytokine 23 72.92 Quite High
Kinase C 5 38.48 Quite Low
Inflammation 48 36.24 Quite Low
cOX1 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Death 107 100.00 Very High Very High Very High
Stress 39 100.00 Very High Very High Very High
Disease 148 99.84 Very High Very High Very High
Apoptosis 344 99.80 Very High Very High Very High
Lymphatic System Cancer 2 99.34 Very High Very High Very High
Targeted Disruption 40 96.16 Very High Very High Very High
Injury 38 89.32 High High
Cancer 104 85.00 Quite High
Hepatotoxicity 5 84.52 Quite High
Multiple Organ Failure 36 79.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the neutralization of opioid activity by naltrexone did not modify Fas mRNA expression in the liver as assessed with real-time quantitative polymerase chain reaction.
Neg (not) Regulation (modify) of Gene_expression (expression) of Fas in liver associated with opioid
1) Confidence 0.38 Published 2004 Journal Hepatology Section Abstract Doc Link 15389866 Disease Relevance 0.73 Pain Relevance 0.96
APAP administration upregulated Cox-2 and B-cell lymphoma-2 (Bcl-2) production and had an effect, albeit minor, on Cox-1 and Fas expression in hepatic tissue.
Regulation (effect) of Gene_expression (expression) of Fas in B-cell associated with paracetamol and lymphatic system cancer
2) Confidence 0.28 Published 2008 Journal Dig. Dis. Sci. Section Abstract Doc Link 18373199 Disease Relevance 0.65 Pain Relevance 0.86
The levels of Fas expression and caspase 8 activities are the same in infected and uninfected liver cells of mice, but hydroxyl radicals are increased in infected mice [36].
Regulation (levels) of Gene_expression (expression) of Fas in liver
3) Confidence 0.26 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2995786 Disease Relevance 1.40 Pain Relevance 0.04
We validated that the expression of Caspase 8, Fas and Birc5 genes was altered by real time RT-PCR (Figure 5).
Regulation (altered) of Gene_expression (expression) of Fas
4) Confidence 0.23 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2610035 Disease Relevance 0.91 Pain Relevance 0
Effect of GW 0742 -treatment on Fas-ligand expression and apoptosis
Regulation (Effect) of Gene_expression (expression) of Fas associated with apoptosis
5) Confidence 0.15 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2844385 Disease Relevance 0.27 Pain Relevance 0
We did not observe any changes in either Fas or FasL expression in U0126-treated HepG2 and Hep3B cells.
Neg (not) Regulation (changes) of Gene_expression (expression) of Fas
6) Confidence 0.15 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 1.00 Pain Relevance 0
FKHs proteins regulate genes controlling cell cycle, cell metabolism, oxidative stress and cell death, such as Fas L, which has been shown to be overexpressed in AD brains [63] and involved in A?
Regulation (regulate) of Gene_expression (overexpressed) of Fas in brains associated with stress, disease and death
7) Confidence 0.13 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.72 Pain Relevance 0

General Comments

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