INT121967

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Context Info
Confidence 0.45
First Reported 2004
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 6.14
Pain Relevance 3.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RAC1) cell motility (RAC1) cell adhesion (RAC1)
plasma membrane (RAC1) enzyme binding (RAC1) GTPase activity (RAC1)
Anatomy Link Frequency
endothelial cell 1
muscle 1
skin 1
RAC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 27 99.92 Very High Very High Very High
Pain 20 99.92 Very High Very High Very High
Pain threshold 1 99.48 Very High Very High Very High
Hyperalgesia 4 97.80 Very High Very High Very High
Chronic pancreatitis 4 96.88 Very High Very High Very High
cINOD 4 94.00 High High
Migraine 2 93.12 High High
agonist 4 87.40 High High
Peripheral sensitization 1 85.28 High High
central sensitization 1 82.48 Quite High
Disease Link Frequency Relevance Heat
Adhesions 44 99.92 Very High Very High Very High
Pain 17 99.48 Very High Very High Very High
Herpes Simplex Virus 238 99.12 Very High Very High Very High
Apoptosis 34 99.12 Very High Very High Very High
Infection 105 98.72 Very High Very High Very High
Clostridium Infection 3 98.50 Very High Very High Very High
Increased Venous Pressure Under Development 4 98.40 Very High Very High Very High
Metastasis 57 98.20 Very High Very High Very High
Hyperalgesia 4 98.20 Very High Very High Very High
Cancer 133 97.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of botulinum toxin on pressure pain threshold and EMG power spectrum of masseter muscle during sustained fatiguing contraction.
Regulation (Effect) of botulinum toxin in muscle associated with pain threshold
1) Confidence 0.45 Published 2010 Journal Am J Phys Med Rehabil Section Title Doc Link 20729652 Disease Relevance 0.10 Pain Relevance 0.19
The effects of Botulinum Toxin type A on capsaicin-evoked pain, flare, and secondary hyperalgesia in an experimental human model of trigeminal sensitization.
Regulation (effects) of Botulinum Toxin associated with pain, hyperalgesia and qutenza
2) Confidence 0.43 Published 2006 Journal Pain Section Title Doc Link 16677761 Disease Relevance 0.78 Pain Relevance 1.32
In this study, we investigated the possible roles of reactive oxygen species (ROS) and Rac1 in capsaicin-induced apoptosis of H-ras MCF10A cells.
Spec (possible) Regulation (roles) of Rac1 associated with qutenza and apoptosis
3) Confidence 0.26 Published 2004 Journal Arch. Pharm. Res. Section Abstract Doc Link 15460446 Disease Relevance 0.44 Pain Relevance 0.65
C3 exotransferase is a toxin derived from Clostridium botulinum and is effective at inhibiting RhoA, -B and -C activity with virtually no effect on Rac1 or Cdc42 [34,35].
Neg (no) Regulation (effect) of Rac1 associated with clostridium infection
4) Confidence 0.22 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.17 Pain Relevance 0
There are no adequate and well-controlled studies of botulinum toxin in pregnant women.
Neg (no) Regulation (controlled) of botulinum toxin
5) Confidence 0.18 Published 2010 Journal Patient Prefer Adherence Section Body Doc Link PMC2943226 Disease Relevance 0.83 Pain Relevance 0
The effect of Botulinum Toxin type A (BoNT/A) on pain and neurogenic vasodilatation induced by application to the human skin of thermal stimuli and capsaicin was evaluated in a double blind study.
Regulation (effect) of Botulinum Toxin in skin associated with pain, qutenza and increased venous pressure under development
6) Confidence 0.14 Published 2007 Journal Pain Section Abstract Doc Link 17194546 Disease Relevance 0.46 Pain Relevance 0.82
Collectively, these results clearly demonstrated that KSHV induced COX-2/PGE2 in the infected cell microenvironment plays an important role in endothelial cell adhesion by modulating the activity of Rac1-GTPases.


Regulation (modulating) of Rac1 in endothelial cell associated with herpes simplex virus and adhesions
7) Confidence 0.14 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.72 Pain Relevance 0.09
In each of these studies RhoA, Rac1 and Cdc42 were not significantly altered nor were they associated with aggressive or metastatic disease.
Neg (not) Regulation (altered) of Rac1 associated with metastasis
8) Confidence 0.04 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 1.49 Pain Relevance 0.19
The resveratrol-mediated induction of p21WAF1 was blocked by treatment with the pure anti-oestrogen ICI 182,780, confirming p21WAF1 gene regulation as an ER-mediated event.


Regulation (regulation) of p21WAF1
9) Confidence 0.00 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400678 Disease Relevance 0.74 Pain Relevance 0.07
Recent studies proposed that the cell cycle inhibitor protein p21WAF1 is a potential downstream target of resveratrol-induced ER signalling pathways [66].
Regulation (target) of p21WAF1
10) Confidence 0.00 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400678 Disease Relevance 0.41 Pain Relevance 0.08

General Comments

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