INT122039

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Context Info
Confidence 0.68
First Reported 2005
Last Reported 2011
Negated 2
Speculated 3
Reported most in Body
Documents 144
Total Number 152
Disease Relevance 113.55
Pain Relevance 28.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ppara) nucleus (Ppara) DNA binding (Ppara)
lipid metabolic process (Ppara)
Anatomy Link Frequency
liver 16
macrophages 4
skeletal muscle 4
fat 4
skin 4
Ppara (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 3316 100.00 Very High Very High Very High
agonist 2690 100.00 Very High Very High Very High
cytokine 675 100.00 Very High Very High Very High
antagonist 202 99.92 Very High Very High Very High
chemokine 96 98.88 Very High Very High Very High
Morphine 9 98.56 Very High Very High Very High
Inflammatory response 286 98.52 Very High Very High Very High
psoriasis 162 98.36 Very High Very High Very High
Central nervous system 262 98.24 Very High Very High Very High
Paracetamol 28 98.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 3810 100.00 Very High Very High Very High
INFLAMMATION 3747 100.00 Very High Very High Very High
Colon Cancer 537 100.00 Very High Very High Very High
Colitis 218 100.00 Very High Very High Very High
Targeted Disruption 603 99.98 Very High Very High Very High
Multiple Sclerosis 223 99.98 Very High Very High Very High
Adult Respiratory Distress Syndrome 9 99.98 Very High Very High Very High
Obesity 1641 99.96 Very High Very High Very High
Apoptosis 710 99.92 Very High Very High Very High
Starvation 64 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, brain PPAR-alpha expression is upregulated after the highest dose of repeated morphine, but not chronic cocaine, suggesting that this receptor could play a homeostatic role.
Positive_regulation (upregulated) of Gene_expression (expression) of PPAR-alpha in brain associated with cocaine and morphine
1) Confidence 0.68 Published 2009 Journal Neuroscience Section Abstract Doc Link 19698765 Disease Relevance 0.14 Pain Relevance 1.08
Currently, we have no explanation for the impairment of PPAR expression that is induced by irradiation.
Positive_regulation (induced) of Gene_expression (expression) of PPAR
2) Confidence 0.61 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 1.03 Pain Relevance 0.12
mice, since adenoviral overexpression of human PPAR?
Positive_regulation (overexpression) of Gene_expression (overexpression) of PPAR
3) Confidence 0.60 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.40 Pain Relevance 0
PEA selectively activates PPAR-alpha in vitro with an EC(50) value of 3.1 +/- 0.4 microM and induces the expression of PPAR-alpha mRNA when applied topically to mouse skin.
Positive_regulation (induces) of Gene_expression (expression) of PPAR-alpha in skin
4) Confidence 0.50 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15465922 Disease Relevance 0.61 Pain Relevance 0.37
PEA selectively activates PPAR-alpha in vitro with an EC(50) value of 3.1 +/- 0.4 microM and induces the expression of PPAR-alpha mRNA when applied topically to mouse skin.
Positive_regulation (induces) of Gene_expression (expression) of PPAR-alpha in skin
5) Confidence 0.50 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15465922 Disease Relevance 0.61 Pain Relevance 0.37
gene for mutations to test the genetic contribution of the PPAR?
Positive_regulation (test) of Gene_expression (contribution) of PPAR
6) Confidence 0.50 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1570084 Disease Relevance 0.99 Pain Relevance 0
activate all of the PPAR subtypes, however, GW4148 and GW9135 have
Positive_regulation (activate) of Gene_expression (subtypes) of PPAR
7) Confidence 0.50 Published 2007 Journal PPAR Research Section Body Doc Link PMC1940322 Disease Relevance 0.18 Pain Relevance 0.38
This may be due in part to cell-autonomous effect of PPAR?
Positive_regulation (due) of Gene_expression (effect) of PPAR
8) Confidence 0.50 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1800345 Disease Relevance 1.94 Pain Relevance 0.53
, has recently been suggested, because PPAR?
Positive_regulation (suggested) of Gene_expression (suggested) of PPAR
9) Confidence 0.50 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1800345 Disease Relevance 1.52 Pain Relevance 0.29
both in the tumor cells as well as in the host is necessary for unabated tumor growth, they also demonstrate that PPAR?
Positive_regulation (demonstrate) of Gene_expression (demonstrate) of PPAR associated with cancer
10) Confidence 0.50 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1800345 Disease Relevance 1.49 Pain Relevance 0
These findings suggest that inadequate PPARalpha expression in steatohepatitic mice sensitizes them to APAP hepatotoxicity.
Positive_regulation (inadequate) of Gene_expression (expression) of PPARalpha associated with paracetamol and hepatotoxicity
11) Confidence 0.50 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18501395 Disease Relevance 0.77 Pain Relevance 0.76
The RXR/PPAR heterodimer is activated by
Positive_regulation (activated) of Gene_expression (heterodimer) of PPAR
12) Confidence 0.50 Published 2006 Journal PPAR Research Section Body Doc Link PMC1664714 Disease Relevance 0.30 Pain Relevance 0.30
agonists of either RXR or PPAR, leading to the activation of
Positive_regulation (leading) of Gene_expression (agonists) of PPAR associated with agonist
13) Confidence 0.50 Published 2006 Journal PPAR Research Section Body Doc Link PMC1664714 Disease Relevance 0.29 Pain Relevance 0.33
The RXR/PPAR heterodimer is activated by
Positive_regulation (/) of Gene_expression (heterodimer) of PPAR
14) Confidence 0.50 Published 2006 Journal PPAR Research Section Body Doc Link PMC1664714 Disease Relevance 0.30 Pain Relevance 0.30
in livers of PPAR?
Positive_regulation (livers) of Gene_expression (livers) of PPAR in livers
15) Confidence 0.49 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0 Pain Relevance 0.09
These findings indicate that CLOCK controls the circadian expression of PPAR?
Positive_regulation (circadian) of Gene_expression (expression) of PPAR
16) Confidence 0.49 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0 Pain Relevance 0
It also appears that the overexpression of human PPAR?
Positive_regulation (overexpression) of Gene_expression (overexpression) of PPAR
17) Confidence 0.49 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.21 Pain Relevance 0.03
in cultured cells and to induce the expression of PPAR?.
Positive_regulation (induce) of Gene_expression (expression) of PPAR
18) Confidence 0.49 Published 2007 Journal PPAR Research Section Body Doc Link PMC2220031 Disease Relevance 0.19 Pain Relevance 0.14
Other dietary components (such as omega-3 fatty acids and polyphenols) that either inhibit toll-like receptors or activate anti-inflammatory gene transcription factors such as PPAR?
Positive_regulation (activate) of Gene_expression (such) of PPAR associated with inflammation
19) Confidence 0.49 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2952901 Disease Relevance 1.41 Pain Relevance 0.49
It should be noted that adiponectin is an adipose-derived hormone that can be increased by high levels of fish oil rich in EPA possibly acting through the PPAR?
Spec (possibly) Positive_regulation (through) of Gene_expression (acting) of PPAR
20) Confidence 0.49 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2952901 Disease Relevance 1.69 Pain Relevance 0.11

General Comments

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