INT122054

From wiki-pain
Revision as of 11:56, 24 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.49
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.85
Pain Relevance 2.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2rx4) transport (P2rx4) plasma membrane (P2rx4)
Anatomy Link Frequency
microglia 3
dorsal horn 2
spinal 1
P2rx4 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 21 100.00 Very High Very High Very High
Peripheral nerve injury 4 100.00 Very High Very High Very High
neuralgia 2 100.00 Very High Very High Very High
Lasting pain 14 99.86 Very High Very High Very High
Brush evoked pain 17 99.40 Very High Very High Very High
Neuropathic pain 13 99.28 Very High Very High Very High
Inflammation 14 97.48 Very High Very High Very High
Spinal cord 4 97.08 Very High Very High Very High
c fibre 1 96.16 Very High Very High Very High
Dorsal horn neuron 3 95.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 22 100.00 Very High Very High Very High
Pain 39 99.86 Very High Very High Very High
Neuropathic Pain 42 99.40 Very High Very High Very High
INFLAMMATION 15 97.48 Very High Very High Very High
Injury 5 84.40 Quite High
Hyperalgesia 1 71.72 Quite High
Hypersensitivity 6 55.36 Quite High
Inflammatory Pain 5 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 4 5.00 Very Low Very Low Very Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Up-regulation of P2X4 receptors in spinal microglia after peripheral nerve injury mediates BDNF release and neuropathic pain.
Positive_regulation (mediates) of in microglia Positive_regulation (Up-regulation) of P2X4 in spinal associated with neuralgia, nervous system injury, neuropathic pain and peripheral nerve injury
1) Confidence 0.49 Published 2008 Journal J. Neurosci. Section Title Doc Link 18971468 Disease Relevance 0.84 Pain Relevance 1.25
Stimulation of P2X4R in microglia induces release of brain-derived neurotrophic factor [9,22,23], a factor that is crucial for producing aberrant excitability of dorsal horn neurons [9,24].
Positive_regulation (induces) of Positive_regulation (Stimulation) of P2X4R in dorsal horn associated with dorsal horn neuron
2) Confidence 0.44 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704200 Disease Relevance 1.64 Pain Relevance 0.93
We also found that tactile allodynia under the chronic pain state requires an activation of P2X4 ionotropic ATP receptor and p38 mitogen-activated protein kinase in spinal microglia.
Positive_regulation (requires) of Positive_regulation (activation) of P2X4 in microglia associated with brush evoked pain and lasting pain
3) Confidence 0.13 Published 2004 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 15467256 Disease Relevance 0.37 Pain Relevance 0.47

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox