INT122191

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Context Info
Confidence 0.36
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.79
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Crh, Ucn) extracellular space (Crh) response to stress (Crh)
cytoplasm (Crh)
Crh (Mus musculus)
Ucn (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 4 96.36 Very High Very High Very High
Spinal cord 6 94.48 High High
antagonist 2 86.88 High High
cerebral cortex 3 85.04 High High
amygdala 8 81.68 Quite High
medulla 4 80.88 Quite High
Hippocampus 2 76.96 Quite High
Visceral pain 2 75.00 Quite High
Pain 7 50.88 Quite High
Dorsal horn 1 50.08 Quite High
Disease Link Frequency Relevance Heat
Stress 40 96.56 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

2 75.00 Quite High
Nociception 3 69.44 Quite High
Targeted Disruption 10 54.00 Quite High
Diabetes Insipidus 1 5.84 Low Low
Hyponatremia 5 5.00 Very Low Very Low Very Low
Anxiety Disorder 4 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Small Cell Lung Cancer 4 5.00 Very Low Very Low Very Low
Cancer 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CRF receptor 1 (CRF1) binds CRF and Ucn1 with similar high affinity, but CRF receptor 2 (CRF2) binds Ucn1 with higher affinity than CRF.
CRF Binding (binds) of Ucn1
1) Confidence 0.36 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17444496 Disease Relevance 0.19 Pain Relevance 0.18
In the systemic circulation, CRH and Ucn1 are known to bind CRH-binding protein (CRH-BP), resulting in the inactivation of CRH and Ucn1 (Potter et al. 1991).
CRH-binding protein Binding (bind) of Ucn1
2) Confidence 0.21 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.05 Pain Relevance 0.27
Urocortin 1 binds with high affinity to CRF type 1 (CRF1) and type 2 (CRF2) receptors while Ucn 2 and Ucn 3 are selective CRF2 ligands.
CRF Binding (binds) of Ucn
3) Confidence 0.16 Published 2004 Journal Peptides Section Abstract Doc Link 15476940 Disease Relevance 0.16 Pain Relevance 0.11
However, after peripheral administration, Ucn 1 and Ucn 2 were more potent than CRF.
CRF Binding (potent) of Ucn 1
4) Confidence 0.14 Published 2004 Journal Peptides Section Abstract Doc Link 15476940 Disease Relevance 0.25 Pain Relevance 0.26

General Comments

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