INT122216

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Context Info
Confidence 0.67
First Reported 2002
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.53
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL1B, CCL5) aging (IL1B, CCL5) extracellular region (IL1B, CCL5)
cell-cell signaling (IL1B, CCL5) cytosol (IL1B) signal transduction (IL1B)
Anatomy Link Frequency
fibroblasts 2
IL1B (Homo sapiens)
CCL5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory mediators 1 88.40 High High
Snapping jaw 4 50.00 Quite Low
Inflammation 19 34.96 Quite Low
metalloproteinase 6 25.28 Quite Low
cytokine 11 20.36 Low Low
chemokine 11 17.28 Low Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
COX2 2 5.00 Very Low Very Low Very Low
Myofascial pain syndrome 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 21 88.00 High High
Temporomandibular Joint Disorders 2 80.60 Quite High
Adhesions 2 66.64 Quite High
Death 6 62.72 Quite High
Cancer 4 52.64 Quite High
Temporomandibular Joint Syndrome 4 50.00 Quite Low
Disease 8 5.00 Very Low Very Low Very Low
Arthritis 5 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low
Necrosis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Protein level of RANTES in synovial fibroblasts was also increased by IL-1beta.
IL-1beta Positive_regulation (increased) of RANTES in fibroblasts
1) Confidence 0.67 Published 2004 Journal J. Oral Pathol. Med. Section Body Doc Link 15482330 Disease Relevance 0.07 Pain Relevance 0
RESULTS: The RANTES was preferentially up-regulated in synovial fibroblasts by IL-1beta.
IL-1beta Positive_regulation (up-regulated) of RANTES in fibroblasts
2) Confidence 0.49 Published 2004 Journal J. Oral Pathol. Med. Section Body Doc Link 15482330 Disease Relevance 0.08 Pain Relevance 0
The production of PGE2, MMP-1, IL-8, IL-6, RANTES and IP-10 induced by hTWEAK (but not the production induced by TNF and IL-1?)
IL-1 Positive_regulation (induced) of RANTES
3) Confidence 0.04 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83846 Disease Relevance 0.38 Pain Relevance 0.04

General Comments

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