INT122266

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Context Info
Confidence 0.27
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.43
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Src, Grin2b) mitochondrion (Src) embryo development (Grin2b)
enzyme binding (Src) response to stress (Src) cytoplasm (Src)
Anatomy Link Frequency
dorsal horn 1
Src (Rattus norvegicus)
Grin2b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate receptor 3 100.00 Very High Very High Very High
antagonist 3 100.00 Very High Very High Very High
Dorsal horn 2 99.98 Very High Very High Very High
Inflammation 10 99.44 Very High Very High Very High
Hyperalgesia 4 96.00 Very High Very High Very High
spinal dorsal horn 4 93.04 High High
nMDA receptor 3 90.80 High High
Calcium channel 1 75.36 Quite High
agonist 2 51.52 Quite High
intrathecal 1 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 7 99.44 Very High Very High Very High
Hyperalgesia 4 96.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we show that in rats with Freund's adjuvant-induced inflammation, the increased dorsal horn NR2B tyr-P is blocked by group I metabotropic glutamate receptor (mGluR) antagonists [7-(hydroxyimino)cyclopropa[b] chromen-1a-carboxylate ethyl ester (CPCCOEt) and 2-methyl-6-(phenylethynyl)-pyridine (MPEP), by the Src inhibitor CGP 77675, but not by the MAP kinase inhibitor 2'-amino-3'-methoxyflavone.
Src Negative_regulation (blocked) of NR2B in dorsal horn associated with inflammation, antagonist, glutamate receptor and dorsal horn
1) Confidence 0.27 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15483135 Disease Relevance 0.43 Pain Relevance 0.91

General Comments

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