INT122267

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Context Info
Confidence 0.26
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.61
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Prkcg, Grin2b) cytosol (Prkcg) nucleus (Prkcg)
intracellular (Prkcg) embryo development (Grin2b) response to stress (Prkcg)
Anatomy Link Frequency
dorsal horn 1
Prkcg (Rattus norvegicus)
Grin2b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 2 99.84 Very High Very High Very High
Inflammation 10 98.32 Very High Very High Very High
Dorsal horn 2 95.30 Very High Very High Very High
Calcium channel 1 86.76 High High
Glutamate receptor 3 85.20 High High
antagonist 3 83.84 Quite High
spinal dorsal horn 4 81.04 Quite High
Hyperalgesia 4 75.00 Quite High
nMDA receptor 3 75.00 Quite High
Dorsal horn neuron 1 72.80 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 7 98.32 Very High Very High Very High
Hyperalgesia 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a dorsal horn slice preparation, the group I (dihydroxyphenylglycine), but not group II [(2R,4R)-4-aminopyrrolidine-2,3-dicarboxylate] and III [L-AP 4 (L-(+)-2-amino-4-phosphonobutyric acid)], mGluR agonists, an IP3 receptor (D-IP3) agonist, and a PKC (PMA) activator, induces NR2B tyr-P similar to that seen in vivo after inflammation.
PKC Positive_regulation (induces) of NR2B in dorsal horn associated with inflammation, agonist and dorsal horn
1) Confidence 0.26 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15483135 Disease Relevance 0.61 Pain Relevance 1.14

General Comments

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