INT12231

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Context Info
Confidence 0.70
First Reported 1980
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 17
Total Number 22
Disease Relevance 4.54
Pain Relevance 13.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Nts)
Anatomy Link Frequency
vagal nerve 6
PAG 4
PFC 4
hypothalamus 2
brain 2
Nts (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 510 100.00 Very High Very High Very High
gABA 69 100.00 Very High Very High Very High
addiction 43 100.00 Very High Very High Very High
Enkephalin 31 100.00 Very High Very High Very High
Opioid 17 100.00 Very High Very High Very High
substance P 5 100.00 Very High Very High Very High
Somatostatin 4 100.00 Very High Very High Very High
vagus nerve 102 99.98 Very High Very High Very High
agonist 22 99.98 Very High Very High Very High
Clonidine 8 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apnoea 54 99.96 Very High Very High Very High
INFLAMMATION 12 99.72 Very High Very High Very High
Urological Neuroanatomy 42 99.68 Very High Very High Very High
Nociception 6 98.40 Very High Very High Very High
Hypothermia 2 94.44 High High
Pain 2 94.32 High High
Dyspnea 30 94.20 High High
Injury 1 86.40 High High
Ulcers 1 79.28 Quite High
Erectile Dysfunction 1 78.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As direct and indirect dopamine agonists have been reported to promote neurotensin release in the cortex, behavioural studies were performed using injection of apomorphine.
Positive_regulation (promote) of Localization (release) of neurotensin in cortex associated with dopamine and agonist
1) Confidence 0.70 Published 1995 Journal Fundam Clin Pharmacol Section Abstract Doc Link 8808171 Disease Relevance 0.26 Pain Relevance 0.67
We found that D2 agonist-elicited increases in PFC GABA levels were blocked by pretreatment with SR48692, consistent with data indicating that D2 autoreceptor agonists increase neurotensin release from dopamine-neurotensin axons in the PFC.
Positive_regulation (increase) of Localization (release) of neurotensin in PFC associated with dopamine, gaba and agonist
2) Confidence 0.66 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15716398 Disease Relevance 0.05 Pain Relevance 0.70
In conclusion, the present data provide in vivo evidence that mu-opioid receptors mediate stimulation of neurotensin release in the PAG.
Positive_regulation (stimulation) of Localization (release) of neurotensin in PAG associated with mu opioid receptor and urological neuroanatomy
3) Confidence 0.63 Published 1997 Journal Brain Res. Section Abstract Doc Link 9452203 Disease Relevance 0.41 Pain Relevance 0.89
Opioid-induced release of neurotensin in the periaqueductal gray matter of freely moving rats.
Positive_regulation (induced) of Localization (release) of neurotensin in gray matter associated with central grey and opioid
4) Confidence 0.63 Published 1997 Journal Brain Res. Section Title Doc Link 9452203 Disease Relevance 0.62 Pain Relevance 1.21
Bombesin potentiates taurocholic acid-induced neurotensin release in rats.
Positive_regulation (induced) of Localization (release) of neurotensin
5) Confidence 0.59 Published 1991 Journal Endocrinology Section Title Doc Link 1709858 Disease Relevance 0 Pain Relevance 0.06
Neurotensin potentiates the potassium-induced release of endogenous dopamine from rat striatal slices.
Positive_regulation (potassium-induced) of Localization (release) of Neurotensin associated with dopamine
6) Confidence 0.50 Published 1983 Journal Eur. J. Pharmacol. Section Title Doc Link 6628546 Disease Relevance 0 Pain Relevance 0.52
The present results suggest that in rat proximal colon the inhibitory action of neurotensin is largely due to production of nitric oxide (NO), likely released from neural prejunctional sites.
Positive_regulation (action) of Localization (released) of neurotensin in neural
7) Confidence 0.50 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9277430 Disease Relevance 0 Pain Relevance 0.14
Dihydrocodeine and dextromethorphan, both central acting antitussive drugs, significantly increased the release of [3H]5-HT from slices of the rat NTS.
Positive_regulation (increased) of Localization (release) of NTS associated with dextromethorphan
8) Confidence 0.44 Published 1992 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 1636059 Disease Relevance 0 Pain Relevance 0.17
In each region, glutamate receptor agonists, N-methyl-D-aspartate (NMDA) and kainic acid, increased neurotensin release 2-3-fold.
Positive_regulation (increased) of Localization (release) of neurotensin associated with glutamate receptor and agonist
9) Confidence 0.39 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11137867 Disease Relevance 0 Pain Relevance 0.45
Rhythmic ATP release in the NTS is dependent upon vagal nerve afferent input
Positive_regulation (upon) of Localization (release) of NTS in vagal nerve
10) Confidence 0.37 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2538935 Disease Relevance 0.42 Pain Relevance 0.15
This possibility is supported by the evidence obtained previously in in vitro experiments showing ATP-induced potentiation of glutamate release from the myelinated afferent terminals in the NTS (Kato & Shigetomi, 2001; Jin et al. 2004).
Positive_regulation (induced) of Localization (release) of NTS associated with glutamate
11) Confidence 0.37 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2538935 Disease Relevance 0.06 Pain Relevance 0.40
Rhythmic ATP release in the NTS does not depend upon inspiratory activity
Neg (not) Positive_regulation (depend) of Localization (release) of NTS
12) Confidence 0.37 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2538935 Disease Relevance 0.26 Pain Relevance 0.03
Electrical stimulation of the vagus nerve evokes ATP release in the NTS
Positive_regulation (evokes) of Localization (release) of NTS in vagus nerve associated with vagus nerve
13) Confidence 0.37 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2538935 Disease Relevance 0 Pain Relevance 0.55
ATP application into the NTS evokes apnoea
Positive_regulation (evokes) of Localization (application) of NTS associated with apnoea
14) Confidence 0.37 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2538935 Disease Relevance 0.18 Pain Relevance 0.28
Rhythmic glutamate release in the NTS: dependence upon vagal nerve afferent input
Positive_regulation (upon) of Localization (release) of NTS in vagal nerve associated with addiction and glutamate
15) Confidence 0.37 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2538935 Disease Relevance 0 Pain Relevance 0.60
However, a low (10 nM) concentration of neurotensin again increased GABA release (160% of basal), but decreased that of dopamine (75% of basal value).
Positive_regulation (increased) of Localization (release) of neurotensin associated with dopamine and gaba
16) Confidence 0.36 Published 1994 Journal Neuroscience Section Abstract Doc Link 7936192 Disease Relevance 0 Pain Relevance 1.42
Thus, unlike enkephalin, increased basal neurotensin release is not sustained with persistent tonic nociception.
Positive_regulation (increased) of Localization (release) of neurotensin associated with nociception and enkephalin
17) Confidence 0.35 Published 1995 Journal Brain Res. Section Abstract Doc Link 8535838 Disease Relevance 1.06 Pain Relevance 1.76
Twenty-four hours after inflammation was induced, neurotensin release was increased 133% and Met-enkephalin release was increased 353% compared to control animals.
Positive_regulation (increased) of Localization (release) of neurotensin associated with inflammation and enkephalin
18) Confidence 0.35 Published 1995 Journal Brain Res. Section Abstract Doc Link 8535838 Disease Relevance 1.06 Pain Relevance 1.53
Clonidine enhanced in a concentration-dependent manner the basal release of GABA from hypothalamus and NTS synaptosomes.
Positive_regulation (enhanced) of Localization (release) of NTS in hypothalamus associated with gaba and clonidine
19) Confidence 0.31 Published 1991 Journal Pharmacol. Res. Section Abstract Doc Link 1749748 Disease Relevance 0 Pain Relevance 0.76
The demonstration of depolarization-induced release of substance P, Met- and Leu-enkephalin, somatostatin, neurotensin, vasoactive intestinal polypeptide and cholecystokinin-like material from various regions of rat brain in vitro supports the hypothesis that these and other neuropeptides may act as neurotransmitters.
Positive_regulation (depolarization-induced) of Localization (release) of neurotensin in brain associated with neurotransmitter, neuropeptide, somatostatin, enkephalin, cholecystokinin and substance p
20) Confidence 0.31 Published 1980 Journal Proc. R. Soc. Lond., B, Biol. Sci. Section Abstract Doc Link 6159655 Disease Relevance 0 Pain Relevance 0.56

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