INT122364

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Context Info
Confidence 0.65
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.79
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (UCN)
Anatomy Link Frequency
neurons 1
endometrium 1
heart 1
sympathetic nervous system 1
mast cells 1
UCN (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 3 93.72 High High
chemokine 1 90.48 High High
cytokine 5 89.88 High High
Inflammation 16 88.48 High High
Inflammatory marker 3 88.12 High High
depression 4 87.36 High High
ischemia 11 69.24 Quite High
endometriosis 8 50.00 Quite Low
cva 15 41.72 Quite Low
Angina 4 41.44 Quite Low
Disease Link Frequency Relevance Heat
Death 4 99.28 Very High Very High Very High
Stress 15 96.68 Very High Very High Very High
Increased Venous Pressure Under Development 4 92.72 High High
Myocardial Infarction 46 91.52 High High
Adhesions 2 89.04 High High
INFLAMMATION 19 88.48 High High
Anxiety Disorder 2 87.68 High High
Depression 3 87.36 High High
Left Ventricular Dysfunction 1 81.84 Quite High
Endometriosis (extended) 8 80.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The characterization of the 41 amino-acid CRF and other peptide members of the mammalian CRF family, urocortin 1, urocortin 2, and urocortin 3, and the cloning of CRF(1) and CRF(2) receptors, which display distinct affinity for CRF ligands, combined with the development of selective CRF receptor antagonists enable us to unravel the importance of CRF(1) receptor in the stress-related endocrine (activation of pituitary-adrenal axis), behavioral (anxiety/depression, altered feeding), autonomic (activation of sympathetic nervous system), and immune responses.
Gene_expression (members) of urocortin in sympathetic nervous system associated with stress, depression, antagonist and anxiety disorder
1) Confidence 0.65 Published 2008 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 19120089 Disease Relevance 0.63 Pain Relevance 0.09
Normal endometrium was weakly positive for both CRH/Ucn.
Gene_expression (positive) of Ucn in endometrium
2) Confidence 0.58 Published 2004 Journal Am. J. Reprod. Immunol. Section Body Doc Link 15494048 Disease Relevance 0.32 Pain Relevance 0
CONCLUSION: High numbers of activated mast cells are present in endometriosis sites that were strongly positive for CRH/Ucn.
Gene_expression (positive) of Ucn in mast cells
3) Confidence 0.58 Published 2004 Journal Am. J. Reprod. Immunol. Section Body Doc Link 15494048 Disease Relevance 0.30 Pain Relevance 0
Several functional studies documented that peripheral injection of CRF or urocortin stimulates colonic transit, motility, Fos expression in myenteric neurons, and defecation through activation of CRF(1) receptors, whereas it decreases ileal contractility via CRF(2) receptors.
Gene_expression (injection) of urocortin in neurons
4) Confidence 0.25 Published 2009 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 20388944 Disease Relevance 0.38 Pain Relevance 0.06
Urocortin, like BNP, is a cardioprotective peptide and can be found in the brain and in the heart [96].
Gene_expression (found) of Urocortin in heart
5) Confidence 0.16 Published 2008 Journal Crit Care Section Body Doc Link PMC2481437 Disease Relevance 1.11 Pain Relevance 0.29

General Comments

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