INT12239

Context Info Confidence 0.62 First Reported 1989 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 11 Total Number 11 Disease Relevance 6.03 Pain Relevance 6.61

signal transduction (CCK) extracellular space (CCK) extracellular region (CCK)

Anatomy Link Frequency plasma 8 neural 2 CCK (Homo sapiens)

Pain Link Frequency Relevance Heat Cholecystokinin 147 100.00 Pain 16 99.12 antagonist 2 98.96 nud 93 98.58 Chronic pancreatitis 27 98.20 tetrodotoxin 1 97.08 Somatostatin 2 80.64 Hyperalgesia 8 75.00 Acute pain 6 75.00 Opioid 6 75.00

Disease Link Frequency Relevance Heat Exocrine Pancreatic Insufficiency 9 99.28 Pain 18 99.12 Dyspepsia 93 98.58 Pancreatitis 27 98.20 Alcoholic Pancreatitis 3 94.12 Alcohol Addiction 3 93.48 Steatorrhea 24 88.56 Hyperalgesia 8 75.00 Sleep Disorders 1 60.36 Neuropathic Pain 6 56.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Effects of ethanol on meal-stimulated secretion of pancreatic polypeptide and cholecystokinin: comparison of healthy volunteers, heavy drinkers, and patients with chronic pancreatitis.

Regulation (Effects) of Localization (secretion) of cholecystokinin associated with chronic pancreatitis and cholecystokinin

1) Confidence 0.62 Published 1996 Journal J. Gastroenterol. Section Title Doc Link 8808434 Disease Relevance 0.56 Pain Relevance 0.50

A randomised, double-blind, cross-over study in ten right-handed volunteers was performed evaluating the influence of cholecystokinin (CCK)-excretion on the perception of pain in a standardised model.

Regulation (influence) of Localization (excretion) of CCK associated with pain and cholecystokinin

2) Confidence 0.62 Published 2003 Journal Pain Section Abstract Doc Link 12927624 Disease Relevance 0.70 Pain Relevance 1.00

Effect of pancreatic enzyme supplementation on postprandial plasma cholecystokinin secretion in patients with pancreatic insufficiency.

Regulation (Effect) of Localization (secretion) of cholecystokinin in plasma associated with exocrine pancreatic insufficiency and cholecystokinin

3) Confidence 0.54 Published 1989 Journal Regul. Pept. Section Title Doc Link 2772268 Disease Relevance 0.85 Pain Relevance 0.43

In the present study, the validity of this hypothesis was investigated in humans by studying the effects of atropine, cisapride, and ethanol on the meal-stimulated secretion of pancreatic polypeptide (PP) and cholecystokinin (CCK) in healthy volunteers, heavy drinkers, and CP patients.

Regulation (effects) of Localization (secretion) of cholecystokinin associated with chronic pancreatitis and cholecystokinin

4) Confidence 0.45 Published 1996 Journal J. Gastroenterol. Section Abstract Doc Link 8808434 Disease Relevance 0.60 Pain Relevance 0.59

In the present study, the validity of this hypothesis was investigated in humans by studying the effects of atropine, cisapride, and ethanol on the meal-stimulated secretion of pancreatic polypeptide (PP) and cholecystokinin (CCK) in healthy volunteers, heavy drinkers, and CP patients.

Regulation (effects) of Localization (secretion) of CCK associated with chronic pancreatitis and cholecystokinin

5) Confidence 0.45 Published 1996 Journal J. Gastroenterol. Section Abstract Doc Link 8808434 Disease Relevance 0.60 Pain Relevance 0.59

A randomised, double-blind, cross-over study in ten right-handed volunteers was performed evaluating the influence of cholecystokinin (CCK)-excretion on the perception of pain in a standardised model.

Regulation (influence) of Localization (excretion) of cholecystokinin associated with pain and cholecystokinin

6) Confidence 0.45 Published 2003 Journal Pain Section Abstract Doc Link 12927624 Disease Relevance 0.70 Pain Relevance 1.00

In conclusion, CCK-stimulated pancreatic enzyme secretion is dependent on cholinergic neural and noncholinergic pathways.

Regulation (dependent) of Localization (secretion) of CCK in neural associated with cholecystokinin

7) Confidence 0.45 Published 1992 Journal Am. J. Physiol. Section Abstract Doc Link 1636705 Disease Relevance 0 Pain Relevance 0.82

Measurement of plasma PYY and CCK concentrations

Regulation (concentrations) of Localization (Measurement) of CCK in plasma associated with cholecystokinin

8) Confidence 0.43 Published 2006 Journal Crit Care Section Body Doc Link PMC1794491 Disease Relevance 0.06 Pain Relevance 0.12

These data are in agreement with the suggestions from previous studies that digestion of nutrients by pancreatic enzymes plays an important role in the regulation of plasma CCK secretion after feeding.

Regulation (role) of Localization (secretion) of CCK in plasma associated with cholecystokinin

9) Confidence 0.27 Published 1989 Journal Regul. Pept. Section Abstract Doc Link 2772268 Disease Relevance 0.74 Pain Relevance 0.39

These data are in agreement with the suggestions from previous studies that digestion of nutrients by pancreatic enzymes plays an important role in the regulation of plasma CCK secretion after feeding.

Regulation (regulation) of Localization (secretion) of CCK in plasma associated with cholecystokinin

10) Confidence 0.27 Published 1989 Journal Regul. Pept. Section Abstract Doc Link 2772268 Disease Relevance 0.73 Pain Relevance 0.39

Therefore, duodenal lipids seem to be responsible for the generation of dyspeptic symptoms in FD through the induction of gastric motor and sensory dysfunction or the altered response to released CCK.

Regulation (altered) of Localization (released) of CCK associated with nud and cholecystokinin

11) Confidence 0.21 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2912117 Disease Relevance 0.48 Pain Relevance 0.76

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