INT12239

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Context Info
Confidence 0.62
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 6.03
Pain Relevance 6.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCK) extracellular space (CCK) extracellular region (CCK)
Anatomy Link Frequency
plasma 8
neural 2
CCK (Homo sapiens)
Pain Link Frequency Relevance Heat
Cholecystokinin 147 100.00 Very High Very High Very High
Pain 16 99.12 Very High Very High Very High
antagonist 2 98.96 Very High Very High Very High
nud 93 98.58 Very High Very High Very High
Chronic pancreatitis 27 98.20 Very High Very High Very High
tetrodotoxin 1 97.08 Very High Very High Very High
Somatostatin 2 80.64 Quite High
Hyperalgesia 8 75.00 Quite High
Acute pain 6 75.00 Quite High
Opioid 6 75.00 Quite High
Disease Link Frequency Relevance Heat
Exocrine Pancreatic Insufficiency 9 99.28 Very High Very High Very High
Pain 18 99.12 Very High Very High Very High
Dyspepsia 93 98.58 Very High Very High Very High
Pancreatitis 27 98.20 Very High Very High Very High
Alcoholic Pancreatitis 3 94.12 High High
Alcohol Addiction 3 93.48 High High
Steatorrhea 24 88.56 High High
Hyperalgesia 8 75.00 Quite High
Sleep Disorders 1 60.36 Quite High
Neuropathic Pain 6 56.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of ethanol on meal-stimulated secretion of pancreatic polypeptide and cholecystokinin: comparison of healthy volunteers, heavy drinkers, and patients with chronic pancreatitis.
Regulation (Effects) of Localization (secretion) of cholecystokinin associated with chronic pancreatitis and cholecystokinin
1) Confidence 0.62 Published 1996 Journal J. Gastroenterol. Section Title Doc Link 8808434 Disease Relevance 0.56 Pain Relevance 0.50
A randomised, double-blind, cross-over study in ten right-handed volunteers was performed evaluating the influence of cholecystokinin (CCK)-excretion on the perception of pain in a standardised model.
Regulation (influence) of Localization (excretion) of CCK associated with pain and cholecystokinin
2) Confidence 0.62 Published 2003 Journal Pain Section Abstract Doc Link 12927624 Disease Relevance 0.70 Pain Relevance 1.00
Effect of pancreatic enzyme supplementation on postprandial plasma cholecystokinin secretion in patients with pancreatic insufficiency.
Regulation (Effect) of Localization (secretion) of cholecystokinin in plasma associated with exocrine pancreatic insufficiency and cholecystokinin
3) Confidence 0.54 Published 1989 Journal Regul. Pept. Section Title Doc Link 2772268 Disease Relevance 0.85 Pain Relevance 0.43
In the present study, the validity of this hypothesis was investigated in humans by studying the effects of atropine, cisapride, and ethanol on the meal-stimulated secretion of pancreatic polypeptide (PP) and cholecystokinin (CCK) in healthy volunteers, heavy drinkers, and CP patients.
Regulation (effects) of Localization (secretion) of cholecystokinin associated with chronic pancreatitis and cholecystokinin
4) Confidence 0.45 Published 1996 Journal J. Gastroenterol. Section Abstract Doc Link 8808434 Disease Relevance 0.60 Pain Relevance 0.59
In the present study, the validity of this hypothesis was investigated in humans by studying the effects of atropine, cisapride, and ethanol on the meal-stimulated secretion of pancreatic polypeptide (PP) and cholecystokinin (CCK) in healthy volunteers, heavy drinkers, and CP patients.
Regulation (effects) of Localization (secretion) of CCK associated with chronic pancreatitis and cholecystokinin
5) Confidence 0.45 Published 1996 Journal J. Gastroenterol. Section Abstract Doc Link 8808434 Disease Relevance 0.60 Pain Relevance 0.59
A randomised, double-blind, cross-over study in ten right-handed volunteers was performed evaluating the influence of cholecystokinin (CCK)-excretion on the perception of pain in a standardised model.
Regulation (influence) of Localization (excretion) of cholecystokinin associated with pain and cholecystokinin
6) Confidence 0.45 Published 2003 Journal Pain Section Abstract Doc Link 12927624 Disease Relevance 0.70 Pain Relevance 1.00
In conclusion, CCK-stimulated pancreatic enzyme secretion is dependent on cholinergic neural and noncholinergic pathways.
Regulation (dependent) of Localization (secretion) of CCK in neural associated with cholecystokinin
7) Confidence 0.45 Published 1992 Journal Am. J. Physiol. Section Abstract Doc Link 1636705 Disease Relevance 0 Pain Relevance 0.82
Measurement of plasma PYY and CCK concentrations
Regulation (concentrations) of Localization (Measurement) of CCK in plasma associated with cholecystokinin
8) Confidence 0.43 Published 2006 Journal Crit Care Section Body Doc Link PMC1794491 Disease Relevance 0.06 Pain Relevance 0.12
These data are in agreement with the suggestions from previous studies that digestion of nutrients by pancreatic enzymes plays an important role in the regulation of plasma CCK secretion after feeding.
Regulation (role) of Localization (secretion) of CCK in plasma associated with cholecystokinin
9) Confidence 0.27 Published 1989 Journal Regul. Pept. Section Abstract Doc Link 2772268 Disease Relevance 0.74 Pain Relevance 0.39
These data are in agreement with the suggestions from previous studies that digestion of nutrients by pancreatic enzymes plays an important role in the regulation of plasma CCK secretion after feeding.
Regulation (regulation) of Localization (secretion) of CCK in plasma associated with cholecystokinin
10) Confidence 0.27 Published 1989 Journal Regul. Pept. Section Abstract Doc Link 2772268 Disease Relevance 0.73 Pain Relevance 0.39
Therefore, duodenal lipids seem to be responsible for the generation of dyspeptic symptoms in FD through the induction of gastric motor and sensory dysfunction or the altered response to released CCK.
Regulation (altered) of Localization (released) of CCK associated with nud and cholecystokinin
11) Confidence 0.21 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2912117 Disease Relevance 0.48 Pain Relevance 0.76

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