INT122534

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Latest revision as of 02:51, 21 September 2012

Context Info
Confidence 0.48
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 3.59
Pain Relevance 1.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Shc1) aging (Shc1) plasma membrane (Shc1)
nucleus (Shc1) cytoplasm (Shc1)
Anatomy Link Frequency
CLP 1
Shc1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 9 97.12 Very High Very High Very High
agonist 8 96.96 Very High Very High Very High
antagonist 14 94.64 High High
Calcitonin gene-related peptide 3 91.48 High High
Hippocampus 6 90.20 High High
Opioid 23 89.40 High High
cytokine 1 88.48 High High
Pain threshold 2 87.56 High High
Pain 8 79.92 Quite High
Inflammatory response 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Aging 13 99.76 Very High Very High Very High
Glioma 13 99.10 Very High Very High Very High
Stress 18 96.96 Very High Very High Very High
Cognitive Disorder 4 95.72 Very High Very High Very High
Diabetes Mellitus 4 95.36 Very High Very High Very High
INFLAMMATION 3 94.72 High High
Insulin Resistance 1 94.20 High High
Birth Weight 1 91.84 High High
Pain 6 87.56 High High
Necrosis 1 83.60 Quite High

[edit] Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest an interaction between the p66(Shc) gene and specific signaling pathways involved in behavioral adaptation to stress and aging.
Shc Binding (interaction) of associated with stress and aging
1) Confidence 0.48 Published 2008 Journal Exp. Gerontol. Section Abstract Doc Link 18065182 Disease Relevance 0.95 Pain Relevance 0.36
These results suggest an interaction between the p66(Shc) gene and specific signaling pathways involved in behavioral adaptation to stress and aging.
p66 Binding (interaction) of associated with stress and aging
2) Confidence 0.48 Published 2008 Journal Exp. Gerontol. Section Abstract Doc Link 18065182 Disease Relevance 0.95 Pain Relevance 0.36
In a more recent study the Met410Val variant (the p66 isoform) was tested for association with longevity using a prospective follow-up design in two independent cohorts of 730 and 563 subjects aged 85 and over [13].
p66 isoform Binding (association) of associated with aging
3) Confidence 0.37 Published 2006 Journal BMC Genet Section Body Doc Link PMC1420326 Disease Relevance 0.65 Pain Relevance 0
We also demonstrate that double point mutations in both the SHC and the PLC?
SHC Binding (point) of
4) Confidence 0.32 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2964534 Disease Relevance 0.05 Pain Relevance 0.03
The Ras/mitogen activated protein kinase (MAPK) pathway and the phosphoinositide 3-kinase (PI3K) pathway are activated primarily through SHC/FRS-2 binding to phosphorylated tyrosine (Y)515, whereas phosphorylated Y816 activates a calcium/calmodulin-dependent protein kinase II (CaMKII) pathway through PLC?.
SHC Binding (binding) of
5) Confidence 0.31 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2964534 Disease Relevance 0 Pain Relevance 0.07
-OR in C6 glioma cells also acts as its own platform for the binding of Shc, etc., since the ?
Shc Binding (binding) of associated with glioma
6) Confidence 0.09 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC88976 Disease Relevance 0.32 Pain Relevance 0.38
In the SLC group, plasma concentrations of TNF-alpha, IL-6, NOx, and tissue MDA levels were reduced and IL-10 level was increased when compared with groups S and SHC 18 h after CLP (P < 0.05).
SHC 18 Binding (compared) of in CLP
7) Confidence 0.00 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15502055 Disease Relevance 0.67 Pain Relevance 0.75

[edit] General Comments

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