INT122653

Context Info Confidence 0.68 First Reported 2001 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 48 Total Number 48 Disease Relevance 22.50 Pain Relevance 5.96

signal transduction (CD4) cell adhesion (CD4) plasma membrane (CD4) enzyme binding (CD4)

Anatomy Link Frequency T cells 46 monocytes 6 synovial fluid 2 macrophages 2 blood 2 CD4 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 417 99.52 addiction 258 97.74 spinal inflammation 305 97.44 Acupuncture 56 95.64 cytokine 370 95.52 rheumatoid arthritis 395 92.32 Opioid 3 82.16 tolerance 37 81.36 corticosteroid 7 79.20 methotrexate 7 78.48

Disease Link Frequency Relevance Heat Malaria 40 100.00 Mucocutaneous Lymph Node Syndrome 2 100.00 Infection 528 99.92 Disease 338 99.92 Acquired Immune Deficiency Syndrome Or Hiv Infection 984 99.72 INFLAMMATION 412 99.52 Cancer 103 99.34 Diabetes Mellitus 12 99.08 Amebic Liver Abscess 62 98.96 Asthma 8 98.92

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In contrast, macaque CD123+ pDCs had higher levels of CD4 expression than monocytes or myeloid DCs [18] and consequently high levels of DARPin 57.2 binding.

Positive_regulation (levels) of Gene_expression (expression) of CD4 in monocytes

1) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929209 Disease Relevance 0.43 Pain Relevance 0

L, recent studies have raised concern about the risk of death from liver, renal, and heart diseases, as well as from "non-AIDS" cancers; incidence of these diseases is increased at lower CD4 counts, with significant differences seen between those with CD4 <350 cells/?

Positive_regulation (increased) of Gene_expression (counts) of CD4 in heart associated with cancer, heart disease, acquired immune deficiency syndrome or hiv infection, disease and death

2) Confidence 0.50 Published 2010 Journal BMC Int Health Hum Rights Section Body Doc Link PMC2864209 Disease Relevance 0.94 Pain Relevance 0

Mean CD4 counts increased to 413 cells/?

Positive_regulation (increased) of Gene_expression (counts) of CD4

3) Confidence 0.50 Published 2010 Journal Patient Prefer Adherence Section Body Doc Link PMC2875719 Disease Relevance 0 Pain Relevance 0

Stratified by CD4 count, 33 of 38 patients (86.8%) with CD4 ?

Positive_regulation (Stratified) of Gene_expression (count) of CD4

4) Confidence 0.50 Published 2006 Journal AIDS Res Ther Section Body Doc Link PMC1468419 Disease Relevance 0.37 Pain Relevance 0

In defervesce phase of the disease, the number of CD4+CD25high regulatory T cells in patients with Kawasaki disease increases to/or above normal levels, while CD4+CD25high regulatory T cells in patients with infectious febrile disease decrease to normal levels [138].

Positive_regulation (increases) of Gene_expression (regulatory T cells) of CD4 in regulatory T cells associated with mucocutaneous lymph node syndrome, fever and disease

5) Confidence 0.48 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 1.31 Pain Relevance 0.08

Five patients had CD4 counts higher or equal to 350/?

Positive_regulation (had) of Gene_expression (counts) of CD4

6) Confidence 0.46 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2374788 Disease Relevance 1.17 Pain Relevance 0.03

In contrast, macaque CD123+ pDCs had higher levels of CD4 expression than monocytes or myeloid DCs [18] and consequently high levels of DARPin 57.2 binding.

Positive_regulation (levels) of Gene_expression (expression) of CD4 in monocytes

7) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929209 Disease Relevance 0.46 Pain Relevance 0

The Maraviroc versus Efavirenz Regimens as Initial Therapy (MERIT) trial [25] showed that compared to EFV, maraviroc was slightly less effective at achieving viral suppression below 50 copies/ml in patients with higher baseline VL but was more effective at increasing CD4 counts in ART-naïve patients.

Positive_regulation (increasing) of Gene_expression (counts) of CD4

8) Confidence 0.45 Published 2010 Journal AIDS Res Ther Section Body Doc Link PMC2890503 Disease Relevance 0.44 Pain Relevance 0.10

However, the proportion of IL-10+ CD4+ T cells was significantly increased [0.36% (0.20–0.95) vs. 0.69% (0.13–1.14); P?

Positive_regulation (increased) of Gene_expression (proportion) of CD4 in T cells

9) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001453 Disease Relevance 0.18 Pain Relevance 0.30

In contrast, the percentage of CD4+ T cells co-expressing the activation marker HLA-DR was significantly higher in infected than in uninfected animals (p?

Positive_regulation (activation) of Gene_expression (expressing) of CD4 in T cells

10) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698465 Disease Relevance 0.24 Pain Relevance 0

CD4+ T cells from healthy donors were transfected with FUGW-FF3 and FUGW-mi-R146a, then stimulated with Phorbol myristate acetate (PMA) (50 ng/ml) and ionomycin (1 ?

Positive_regulation (with) of Gene_expression (transfected) of CD4 in T cells

11) Confidence 0.41 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 0.21 Pain Relevance 0.13

We suspect that increased levels of CD3+CD4+CD28- T cells in the elderly may be a consequence of reduced apoptosis and persistence of these cells after an inflammatory disease over the years.

Positive_regulation (increased) of Gene_expression (levels) of CD4+ in T cells associated with inflammation, disease and apoptosis

12) Confidence 0.39 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193730 Disease Relevance 1.44 Pain Relevance 0.47

All 11 patients expressed at least one of these NK receptors on the surface of their CD4+CD28- T cells.

Positive_regulation (one) of Gene_expression (expressed) of CD4+ in T cells

13) Confidence 0.39 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193730 Disease Relevance 0 Pain Relevance 0

This co-incubation with HLA-B27 transfected C1R cells resulted in an increased expression of CD25 on CD4+CD28- T cells in the presence of cross-linking of T cell receptors as compared with co-incubation with nontransfected C1R cells (P = 0.012) and cross-linking of T cell receptors alone (P = 0.012; Fig. 5a).

Positive_regulation (increased) of Gene_expression (expression) of CD4+ in T cell

14) Confidence 0.39 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193730 Disease Relevance 0 Pain Relevance 0

mediated generation of CD4+IL-9+ T cells in presence of pbCD3/sCD28 activation.

Positive_regulation (mediated) of Gene_expression (generation) of CD4 in T cells

15) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0.24 Pain Relevance 0.27

mediated generation of CD4+IL-9+ T cells in presence of pbCD3/sCD28 activation.

Positive_regulation (generation) of Gene_expression (generation) of CD4 in T cells

16) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0.24 Pain Relevance 0.27

This suggests a possible role of IL-2 in maintaining viability of CD4+IL-9+T cells generated from resting memory CD4+CD25?

Positive_regulation (generated) of Gene_expression (resting) of CD4 in T cells

17) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0 Pain Relevance 0.11

To address this, we activated freshly isolated CD4+CD25?

Positive_regulation (isolated) of Gene_expression (isolated) of CD4

18) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0.29 Pain Relevance 0.12

In conclusion, our results demonstrate that intradermally injected HIV lipopeptides induce complementary CD4+ and CD8+ T-cell responses.

Positive_regulation (induce) of Gene_expression (responses) of CD4 in T-cell associated with acquired immune deficiency syndrome or hiv infection

19) Confidence 0.37 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1942115 Disease Relevance 0.61 Pain Relevance 0

Preservation of CD4+ T-cell depletion in the GALT during primary infection may be a key event in delaying disease progression.

Positive_regulation (Preservation) of Gene_expression (depletion) of CD4 in T-cell associated with disease progression and infection

20) Confidence 0.37 Published 2001 Journal BMC Infect Dis Section Body Doc Link PMC37356 Disease Relevance 0.30 Pain Relevance 0

General Comments

This test has worked.