INT122656

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Context Info
Confidence 0.75
First Reported 1997
Last Reported 2011
Negated 2
Speculated 1
Reported most in Body
Documents 21
Total Number 22
Disease Relevance 6.37
Pain Relevance 2.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (MTNR1A) signal transducer activity (MTNR1A)
Anatomy Link Frequency
pineal gland 4
MT2 3
forebrain 2
neurons 1
MTNR1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Cannabinoid receptor 9 100.00 Very High Very High Very High
dorsal root ganglion 21 99.84 Very High Very High Very High
qutenza 16 96.48 Very High Very High Very High
nud 32 93.64 High High
opiate 4 93.08 High High
agonist 31 93.04 High High
dopamine receptor 3 92.76 High High
Pain 60 92.20 High High
Serotonin 4 91.48 High High
Cancer pain 41 85.80 High High
Disease Link Frequency Relevance Heat
Scoliosis 314 100.00 Very High Very High Very High
Ganglion Cysts 23 99.84 Very High Very High Very High
Gastroesophageal Reflux Disease 196 99.28 Very High Very High Very High
Disease 163 98.68 Very High Very High Very High
Facioscapulohumeral Muscular Dystrophy 150 96.32 Very High Very High Very High
Sleep Disorders 41 94.12 High High
Dyspepsia 32 93.64 High High
Pain 62 92.20 High High
Infection 322 90.08 High High
Breast Cancer 18 89.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ramelteon inhibited forskolin-stimulated cAMP production in the CHO cells that express the human MT1 or MT2 receptors.
Gene_expression (express) of MT1 in MT2
1) Confidence 0.75 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15695169 Disease Relevance 0.06 Pain Relevance 0.25
Ramelteon showed very high affinity for human MT1 (Mel1a) and MT2 (Mel1b) receptors (expressed in Chinese hamster ovary [CHO] cells), and chick forebrain melatonin receptors (consisting of Mel1a and Mel1c receptors) with Ki values of 14.0, 112, and 23.1 pM, respectively, making the affinities of ramelteon for these receptors 3-16 times higher than those of melatonin.
Gene_expression (expressed) of MT1 in forebrain
2) Confidence 0.65 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15695169 Disease Relevance 0.09 Pain Relevance 0.16
Ramelteon showed very high affinity for human MT1 (Mel1a) and MT2 (Mel1b) receptors (expressed in Chinese hamster ovary [CHO] cells), and chick forebrain melatonin receptors (consisting of Mel1a and Mel1c receptors) with Ki values of 14.0, 112, and 23.1 pM, respectively, making the affinities of ramelteon for these receptors 3-16 times higher than those of melatonin.
Gene_expression (expressed) of Mel1a in forebrain
3) Confidence 0.65 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15695169 Disease Relevance 0.09 Pain Relevance 0.16
Furthermore, in cells natively co-expressing GPR50 and the MT1 receptor, specific [125I]melatonin binding could not be observed until GPR50 levels were reduced via a siRNA (small interfering RNA)-based approach [27].
Gene_expression (expressing) of MT1
4) Confidence 0.49 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2474558 Disease Relevance 0.06 Pain Relevance 0.27
The adjacent gene MTNRIA, a melatonin receptor gene, had a highly reproducible DH site within the first intron, but not at the 5?
Neg (not) Gene_expression (had) of melatonin receptor gene
5) Confidence 0.45 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2794184 Disease Relevance 0.24 Pain Relevance 0
(B) DH sites in the FAT1 and MTNR1A regions are cell type-specific.
Gene_expression (sites) of MTNR1A
6) Confidence 0.45 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2794184 Disease Relevance 0.72 Pain Relevance 0
Postural scoliosis in melatonin-deficient mice
Gene_expression (scoliosis) of melatonin associated with scoliosis
7) Confidence 0.44 Published 2009 Journal Scoliosis Section Body Doc Link PMC2781798 Disease Relevance 0.96 Pain Relevance 0.06
Melatonin is a hormone produced mainly in the pineal gland.
Gene_expression (produced) of Melatonin in pineal gland
8) Confidence 0.31 Published 2005 Journal Am J Hosp Palliat Care Section Abstract Doc Link 16082917 Disease Relevance 0.17 Pain Relevance 0.07
Further, there is loss of expression of AVP and MT1 receptors in the SCN.
Gene_expression (expression) of MT1
9) Confidence 0.30 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2939436 Disease Relevance 0.50 Pain Relevance 0.11
We can confirm that as reported in the literature BV2 cells express Adora3 [59], Cnr2 [33,58], Mtnr1a [60], Galr2 [61], Ccr5, Cxcr3 [62] and Rgs2, 10, 12 [27,28,63].
Gene_expression (express) of Mtnr1a associated with cannabinoid receptor
10) Confidence 0.17 Published 2011 Journal BMC Genomics Section Body Doc Link PMC3024950 Disease Relevance 0 Pain Relevance 0.09
Among the groups in the heavy endemic areas, the PRs in the MT2 and MT1 groups were 18.8% and 8.4% in 2004, respectively.
Gene_expression (groups) of MT1 in MT2
11) Confidence 0.11 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2821909 Disease Relevance 0.13 Pain Relevance 0
Among the infected subjects in the heavy endemic areas, the ERRs in the MT1 and ST6M groups were higher than those of the ST1 group (both p<0.01), but those in the MT2 and ST1R groups were not significantly different.


Gene_expression (group) of MT1 in MT2
12) Confidence 0.11 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2821909 Disease Relevance 0.08 Pain Relevance 0
Relative to the reference ST1 group, the MT1 group had a 0.6-fold lower PR (15.0% for ST1 group; 8.4% for MT1 group; POR?
Gene_expression (group) of MT1
13) Confidence 0.11 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2821909 Disease Relevance 0.13 Pain Relevance 0
Relative to the reference ST1 group, the MT1 group had a 0.6-fold lower PR (15.0% for ST1 group; 8.4% for MT1 group; POR?
Gene_expression (group) of MT1
14) Confidence 0.11 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2821909 Disease Relevance 0.13 Pain Relevance 0
1,999), which was treated every two years, and the MT1 group (n?
Gene_expression (group) of MT1
15) Confidence 0.11 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2821909 Disease Relevance 0.21 Pain Relevance 0
Circulating levels of melatonin were analysed as integrated values (areas under the curve [AUC]) over 24 hours, 5 to 2 days before and 4 days after delivery.
Spec (analysed) Gene_expression (levels) of melatonin
16) Confidence 0.07 Published 1997 Journal J Obstet Gynaecol Section Abstract Doc Link 15511919 Disease Relevance 0 Pain Relevance 0
Elevated serum melatonin levels during human late pregnancy and labour.
Gene_expression (levels) of melatonin
17) Confidence 0.07 Published 1997 Journal J Obstet Gynaecol Section Title Doc Link 15511919 Disease Relevance 0 Pain Relevance 0.12
The pineal gland is the major source of melatonin in the peripheral circulation, producing melatonin in a distinct circadian fashion, with peak levels occurring during the night [13].
Gene_expression (producing) of melatonin in pineal gland
18) Confidence 0.01 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2821302 Disease Relevance 0 Pain Relevance 0.04
The results of the researches have provided the evidence that melatonin is synthesized not only in the pineal gland, but also in different organs.
Gene_expression (synthesized) of melatonin in pineal gland
19) Confidence 0.01 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2821302 Disease Relevance 0.56 Pain Relevance 0.05
The pineal gland is the major source of melatonin in the peripheral circulation, producing melatonin in a distinct circadian fashion, with peak levels occurring during the night [13].
Gene_expression (source) of melatonin in pineal gland
20) Confidence 0.01 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2821302 Disease Relevance 0 Pain Relevance 0.05

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