INT122672

Context Info Confidence 0.06 First Reported 2005 Last Reported 2005 Negated 2 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 1.15 Pain Relevance 1.44

cytosol (LCK) aging (LCK) Golgi apparatus (LCK) plasma membrane (LCK) cytoplasm (LCK)

Anatomy Link Frequency lymphocyte 4 LCK (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 18 99.80 Inflammation 2 55.32 cOX1 2 25.00

Disease Link Frequency Relevance Heat Stress 12 94.40 INFLAMMATION 6 75.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Furthermore, activation of Fyn, which controls Vav phosphorylation, is inhibited by NSAIDs, whereas activation of lymphocyte-specific protein tyrosine kinase (Lck) and of the Lck-dependent tyrosine kinase cascade is unaffected.

Neg (unaffected) Regulation (unaffected) of Positive_regulation (activation) of Lck in lymphocyte associated with cinod

1) Confidence 0.06 Published 2005 Journal Blood Section Abstract Doc Link 15514010 Disease Relevance 0.58 Pain Relevance 0.72

Furthermore, activation of Fyn, which controls Vav phosphorylation, is inhibited by NSAIDs, whereas activation of lymphocyte-specific protein tyrosine kinase (Lck) and of the Lck-dependent tyrosine kinase cascade is unaffected.

Neg (unaffected) Regulation (unaffected) of Positive_regulation (activation) of lymphocyte-specific protein tyrosine kinase in lymphocyte associated with cinod

2) Confidence 0.06 Published 2005 Journal Blood Section Abstract Doc Link 15514010 Disease Relevance 0.58 Pain Relevance 0.72

General Comments

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