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Context Info
Confidence 0.57
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.03
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HGD) small molecule metabolic process (HGD) oxidoreductase activity (HGD)
cellular nitrogen compound metabolic process (HGD) cellular amino acid metabolic process (HGD)
Anatomy Link Frequency
connective tissue 1
HGD (Homo sapiens)
Pain Link Frequency Relevance Heat
colic 1 82.40 Quite High
anesthesia 4 75.00 Quite High
Pain 1 75.00 Quite High
backache 1 74.56 Quite High
epidural 1 55.84 Quite High
rheumatoid arthritis 1 25.00 Low Low
Arthritis 1 25.00 Low Low
spinal inflammation 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Ochronosis 9 99.72 Very High Very High Very High
Metabolic Disorder 1 98.64 Very High Very High Very High
Alkaptonuria 10 98.48 Very High Very High Very High
Arthropathy 1 95.00 High High
Valvular Heart Disease Other Than Mitral Valve Prolapse 1 87.04 High High
Emergencies 1 84.96 Quite High
Pigment Disorder 3 84.16 Quite High
Renal Colic 1 82.88 Quite High
Calculi 1 78.72 Quite High
Low Back Pain 2 75.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alkaptonuria, a rare autosomal-recessive disorder caused by mutations in the HGD gene and a deficiency of homogentisate 1,2-dioxygenase, is characterized by accumulation of homogentisic acid (HGA), ochronosis, and destruction of connective tissue resulting in joint disease.
Negative_regulation (deficiency) of homogentisate 1,2-dioxygenase in connective tissue associated with alkaptonuria, arthropathy and ochronosis
1) Confidence 0.57 Published 2004 Journal Arthritis Rheum. Section Abstract Doc Link 15529343 Disease Relevance 0.87 Pain Relevance 0.07
Alkaptonuric ochronosis, caused by a deficiency of homogentisate 1,2-dioxygenase, is a rare, autosomal recessive, metabolic disorder.
Negative_regulation (deficiency) of homogentisate 1,2-dioxygenase associated with metabolic disorder and ochronosis
2) Confidence 0.57 Published 2008 Journal Masui Section Abstract Doc Link 18416199 Disease Relevance 0.57 Pain Relevance 0.23
Alkaptonuria is a rare recessive disorder of phenylalanine/tyrosine metabolism due to a defect in the enzyme homogentisate 1,2-dioxygenase (HGD) caused by mutations in the HGD gene.
Negative_regulation (defect) of homogentisate 1,2-dioxygenase associated with alkaptonuria
3) Confidence 0.42 Published 2009 Journal Clin. Chim. Acta Section Abstract Doc Link 19306858 Disease Relevance 0.59 Pain Relevance 0.12

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