INT122881

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Context Info
Confidence 0.51
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 5.52
Pain Relevance 2.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk3) plasma membrane (Ntrk3) kinase activity (Ntrk3)
cytoplasm (Ntrk3)
Anatomy Link Frequency
neurons 3
sensory neurons 2
embryos 1
forebrain 1
palate 1
Ntrk3 (Mus musculus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 227 99.26 Very High Very High Very High
nociceptor 108 99.12 Very High Very High Very High
Spinal cord 31 97.60 Very High Very High Very High
Neuropeptide 12 97.16 Very High Very High Very High
long-term potentiation 2 89.44 High High
calcitonin gene related peptide 33 89.28 High High
qutenza 2 86.68 High High
Pain threshold 8 85.20 High High
Nerve growth factor 83 83.44 Quite High
Hippocampus 5 78.72 Quite High
Disease Link Frequency Relevance Heat
Nociception 72 100.00 Very High Very High Very High
Ganglion Cysts 262 99.26 Very High Very High Very High
Targeted Disruption 169 98.58 Very High Very High Very High
Disease 29 98.28 Very High Very High Very High
Repression 21 97.24 Very High Very High Very High
Cognitive Disorder 12 92.88 High High
Brain Injury 5 90.32 High High
Apoptosis 104 85.92 High High
Pain 56 85.20 High High
Death 106 84.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The number of TG neurons was strongly decreased in the knockout mice as compared to wildtype and heterozygous mice (82%, 39%, and 48% reduction for trkA, trkB and trkC, respectively).
Negative_regulation (reduction) of trkC in neurons associated with targeted disruption
1) Confidence 0.51 Published 2004 Journal Acta Histochem. Section Abstract Doc Link 15530548 Disease Relevance 0.53 Pain Relevance 0.29
At birth, the TG of Brn3a-/- mice exhibit a profound loss of TrkC, Runx3, and multiple nociceptor channels and receptors, while sensory neuropeptide expression is maintained.
Negative_regulation (loss) of TrkC in nociceptor associated with nociceptor, trigeminal ganglion and neuropeptide
2) Confidence 0.40 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.59 Pain Relevance 0.44
Loss of Runx3 may lead to the failure of TrkB and TrkC to segregate into distinct lineages, consistent with previous work demonstrating that Runx3 represses TrkB expression while promoting expression of TrkC [23,44].
Negative_regulation (failure) of TrkC
3) Confidence 0.40 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.27 Pain Relevance 0.17
Thus this specific defect of the TrkC neurons might suggest an involvement of Necdin in axonal growth.
Negative_regulation (defect) of TrkC in neurons
4) Confidence 0.40 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.37 Pain Relevance 0.08
In accordance, we found cellular defects and revealed a loss of nociceptive (TrkA) and proprioceptive (TrkC) sensory neurons.
Negative_regulation (loss) of TrkC in sensory neurons associated with nociception
5) Confidence 0.40 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.85 Pain Relevance 0.09
These data indicate that the abrogation of Necdin results in a partial loss of sensory neurons expressing TrkA and TrkC receptors.
Spec (partial) Negative_regulation (loss) of TrkC in sensory neurons
6) Confidence 0.40 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.32 Pain Relevance 0
Loss of trkC diminished the number of PGP 9.5-ip varicose fibers in the deep layer of mucosal connective tissue of the palate.
Negative_regulation (Loss) of trkC in palate
7) Confidence 0.38 Published 2004 Journal Acta Histochem. Section Abstract Doc Link 15530548 Disease Relevance 0.67 Pain Relevance 0.24
However,, the pool of lumbar DRGs revealed a significant reduction of 26.2% in the density of Trka-expressing cells (WT: 2258 (1999, 2530), n = 5; Ndn KO: 1714 (1450, 1811), n = 5; *p < 0.05) (Fig. 2D,G,J) and a reduction of 37.8% in Trkc-positive neurons (WT: 292 (277, 321), n = 5; Ndn KO: 188 (157, 223), n = 5; *p < 0.05) (Fig. 2F,I,J)) in the mutant embryos.
Negative_regulation (reduction) of Trkc in embryos
8) Confidence 0.35 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0 Pain Relevance 0
Nakamura et al. [49] have observed that the DRG of Runx3 knockouts lack early TrkC+ proprioceptors, but that some TrkC+ neurons appear after E14.5.
Negative_regulation (lack) of TrkC in neurons
9) Confidence 0.29 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.64 Pain Relevance 0.37
The Trk inhibitor (ARRY-470; Array BioPharma, Boulder, CO) is a potent inhibitor of the tropomyosin kinase family of neurotrophin receptors, demonstrating nanomolar cellular inhibition of TrkA (6.5 nM), TrkB (8.1 nM), and TrkC (10.6 nM) and a high level of selectivity over a panel of kinases run at the ATP Km at 1.0 uM and non-kinase receptors [48](Additional file 1 Table S1 and S2).
Negative_regulation (inhibition) of TrkC
10) Confidence 0.28 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004846 Disease Relevance 0.22 Pain Relevance 0.08
Furthermore, the receptors TrkB and TrkC are decreased in cholinergic basal forebrain neurons in AD [55].
Negative_regulation (decreased) of TrkC in forebrain associated with disease
11) Confidence 0.16 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 1.07 Pain Relevance 0.28

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