INT123177

Context Info Confidence 0.70 First Reported 2004 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 5 Disease Relevance 1.37 Pain Relevance 0.09

signal transduction (Gast)

Anatomy Link Frequency muscle 2 stomach 2 Gast (Mus musculus)

Pain Link Frequency Relevance Heat halothane 38 85.44 cINOD 4 50.00 Action potential 4 35.36 peptic ulcer disease 2 33.28 isoflurane 38 5.00 gABA 26 5.00 nMDA receptor 24 5.00 agonist 14 5.00 potassium channel 6 5.00 analgesia 6 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 22 99.88 Helicobacter Infection 2 99.28 Frailty 4 98.68 Ulcers 6 94.92 Infection 4 88.96 Injury 2 50.00 INFLAMMATION 2 50.00 Stomach Cancer 2 44.24 Ganglion Cysts 2 13.76 Unconsciousness 8 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Overexpression of glycine-extended gastrin inhibits parietal cell loss and atrophy in the mouse stomach.

Positive_regulation (Overexpression) of Gene_expression (Overexpression) of gastrin in stomach associated with frailty

1) Confidence 0.70 Published 2004 Journal Cancer Res. Section Title Doc Link 15548680 Disease Relevance 0.69 Pain Relevance 0

Transgenic mice overexpressing amidated gastrin (INS-GAS mice), G-gly (MTI/G-gly mice), and both peptides (INS-GAS/G-gly mice) were used for assessment of acid secretion and ulcer susceptibility and histologic examination and scoring of preneoplastic lesions in response to the 3 and 6 months Helicobacter felis (H. felis) infection.

Positive_regulation (overexpressing) of Gene_expression (overexpressing) of gastrin associated with targeted disruption, ulcers and infection

2) Confidence 0.47 Published 2004 Journal Cancer Res. Section Abstract Doc Link 15548680 Disease Relevance 0.69 Pain Relevance 0

Use of NSAIDs should increase suspicion of cryptic GAS infection in patients with increasing pain at sites of nonpenetrating muscle injury.

Positive_regulation (increase) of Gene_expression (infection) of GAS in muscle

3) Confidence 0.41 Published 2008 Journal J. Infect. Dis. Section Body Doc Link 18939933 Disease Relevance 0 Pain Relevance 0

On application of pressures up to 274 atm by increasing the amount of helium (a non-anaesthetic gas at these pressures) in the container, these changes were reversed: S?

Positive_regulation (increasing) of Gene_expression (anaesthetic) of gas

4) Confidence 0.14 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989583 Disease Relevance 0 Pain Relevance 0.04

On application of pressures up to 274 atm by increasing the amount of helium (a non-anaesthetic gas at these pressures) in the container, these changes were reversed: S?

Positive_regulation (increasing) of Gene_expression (pressures) of gas

5) Confidence 0.14 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989583 Disease Relevance 0 Pain Relevance 0.04

General Comments

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