INT123451

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Context Info
Confidence 0.37
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 0
Pain Relevance 2.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (YY1, Adra2a) cell differentiation (YY1) intracellular (YY1)
DNA binding (YY1) cytoplasm (Adra2a) signal transducer activity (Adra2a)
Anatomy Link Frequency
spinal 1
neurite 1
YY1 (Homo sapiens)
Adra2a (Mus musculus)
Pain Link Frequency Relevance Heat
opiate 24 100.00 Very High Very High Very High
agonist 4 97.28 Very High Very High Very High
analgesia 8 96.52 Very High Very High Very High
Delta opioid receptors 12 91.64 High High
Spinal cord 4 70.68 Quite High
Opioid 4 68.36 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using coimmunoprecipitation of differentially epitope-tagged receptors, we found that delta opiate receptors exist in interacting complexes with alpha2A-adrenoceptors in heterologous cells. 4.
delta Binding (complexes) of alpha2A-adrenoceptors associated with opiate
1) Confidence 0.37 Published 2004 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 15566403 Disease Relevance 0 Pain Relevance 0.68
Using coimmunoprecipitation of differentially epitope-tagged receptors, we found that delta opiate receptors exist in interacting complexes with alpha2A-adrenoceptors in heterologous cells. 4.
delta Binding (interacting) of alpha2A-adrenoceptors associated with opiate
2) Confidence 0.37 Published 2004 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 15566403 Disease Relevance 0 Pain Relevance 0.68
Finally, using receptor activity mediated neurite outgrowth in Neuro 2A cells as a physiological readout, we found that interactions between delta opiate receptors and alpha2A-adrenoceptors have functional consequences.
delta Binding (interactions) of alpha2A-adrenoceptors in neurite associated with opiate
3) Confidence 0.37 Published 2004 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 15566403 Disease Relevance 0 Pain Relevance 0.85
Taken together, these findings suggest that modulation of receptor function as a result of physical associations between delta opiate receptors and alpha2A-adrenoceptors may account for the observed synergy between opiate and adrenergic agonists in spinal analgesia.
delta Binding (associations) of alpha2A-adrenoceptors in spinal associated with agonist, opiate and analgesia
4) Confidence 0.32 Published 2004 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 15566403 Disease Relevance 0 Pain Relevance 0.78

General Comments

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