INT123536

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Context Info
Confidence 0.57
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.74
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MTHFR) small molecule metabolic process (MTHFR) oxidoreductase activity (MTHFR)
cellular amino acid metabolic process (MTHFR)
Anatomy Link Frequency
B12 1
MTHFR (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 80 98.54 Very High Very High Very High
Migraine 77 86.56 High High
abdominal pain 1 84.76 Quite High
depression 45 80.56 Quite High
monoamine 2 73.36 Quite High
Dopamine 3 71.84 Quite High
Serotonin 1 69.52 Quite High
chemokine 4 31.48 Quite Low
antidepressant 19 5.00 Very Low Very Low Very Low
alcohol 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 396 100.00 Very High Very High Very High
Migraine Without Aura 18 99.12 Very High Very High Very High
INFLAMMATION 80 98.54 Very High Very High Very High
Cardiovascular Disease 9 97.04 Very High Very High Very High
Hyperhomocysteinemia 5 96.92 Very High Very High Very High
Diabetes Mellitus 4 96.48 Very High Very High Very High
Cancer 64 94.80 High High
Migraine With Aura 44 91.60 High High
Thrombosis 1 90.48 High High
Cv General 4 Under Development 1 87.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two recent studies on diabetes and cardiovascular diseases have suggested a common pathobiological mechanism between the inflammation process and genotype TT of MTHFR c.665C>T (aka C677T), i.e., a genotype inducing a lower MTHFR activity like genotype MTHFR c.1286CC [57,58].
Positive_regulation (inducing) of MTHFR associated with inflammation, cardiovascular disease and diabetes mellitus
1) Confidence 0.57 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2585099 Disease Relevance 0.98 Pain Relevance 0.17
Furthermore, no genotypic association was indicated for the MTHFR gene variant and the MO subtype (P > 0.1), nor was there any gender-specific associations observed for this variant (results not shown).


Neg (nor) Positive_regulation (indicated) of MTHFR associated with migraine without aura
2) Confidence 0.50 Published 2004 Journal BMC Med Section Body Doc Link PMC375543 Disease Relevance 0.62 Pain Relevance 0.30
Our case is of particular interest because the patient reported herein, is homozygote for the MTHFR 677C/T mutation, while the only two other cases reported in the literature with similar gene mutations, were heterozygotes for the mutation.
Positive_regulation (homozygote) of MTHFR
3) Confidence 0.49 Published 2004 Journal Hematol. J. Section Abstract Doc Link 15570301 Disease Relevance 0.60 Pain Relevance 0.08
When folate levels are adequate, the reduced MTHFR activity induced by the same genotypes would lead to a great pool of methylenetetrahydrofolate available for DNA synthesis, and therefore prevent cancer by diminishing uracil misincorporation.
Positive_regulation (induced) of MTHFR associated with cancer
4) Confidence 0.44 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2585099 Disease Relevance 0.68 Pain Relevance 0.06
Homocysteine can be remethylated to methionine via the 5-methyl-tetrahydrofolate pathway that is mediated by the 5,10-methylenetetrahydrofolate reductase (MTHFR) enzyme and requires B12 and folic acid, or condensed with serine to form cysthionine in a reaction that uses vitamin B6 [17].
Positive_regulation (mediated) of MTHFR in B12
5) Confidence 0.43 Published 2010 Journal Trials Section Body Doc Link PMC2822769 Disease Relevance 0.51 Pain Relevance 0.34
By independent single-SNP analyses, three SNPs were shown to increase CRC risk: PTGS1 c.639C>A, IL8 c.-352T>A, and MTHFR c.1286A>C.
Positive_regulation (increase) of MTHFR associated with colon cancer
6) Confidence 0.41 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2585099 Disease Relevance 0.87 Pain Relevance 0.03
Two polymorphisms c.665C>T (also reported as C677T) and c.1286A>C (aka c.1298A>C), have been widely tested for modification of CRC risk, because of the reduction in MTHFR activity induced by their minor allele.
Positive_regulation (induced) of MTHFR associated with colon cancer
7) Confidence 0.39 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2585099 Disease Relevance 0.49 Pain Relevance 0.03

General Comments

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