INT123557

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Context Info
Confidence 0.78
First Reported 2004
Last Reported 2010
Negated 0
Speculated 4
Reported most in Body
Documents 9
Total Number 16
Disease Relevance 11.21
Pain Relevance 5.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Atf3) nucleus (Atf3) DNA binding (Atf3)
Anatomy Link Frequency
primary sensory neurons 3
sciatic nerve 2
neurons 2
spinal cord 1
nerve 1
Atf3 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 44 98.90 Very High Very High Very High
Spinal cord 174 98.84 Very High Very High Very High
diabetic neuropathy 21 98.60 Very High Very High Very High
Eae 96 98.38 Very High Very High Very High
Sciatic nerve 42 97.16 Very High Very High Very High
unmyelinated 14 96.48 Very High Very High Very High
Dorsal horn 126 96.20 Very High Very High Very High
Peripheral nerve injury 7 94.68 High High
Neuropathic pain 120 94.48 High High
nav1.8 90 90.04 High High
Disease Link Frequency Relevance Heat
Injury 37 100.00 Very High Very High Very High
Nervous System Injury 47 99.88 Very High Very High Very High
Diabetes Mellitus 63 99.82 Very High Very High Very High
Targeted Disruption 410 99.46 Very High Very High Very High
Fibrosis 38 98.90 Very High Very High Very High
Diabetic Neuropathy 21 98.60 Very High Very High Very High
Neuropathic Pain 192 98.24 Very High Very High Very High
Arrhythmias 2 Under Development 54 94.92 High High
Hypoalagesia 7 87.44 High High
Cardiovascular Disorder Under Development 6 86.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine whether diabetes-induced axonal degeneration induces gene expression similar to nerve injury, the expression of activating transcription factor 3 (ATF3) by primary sensory neurons was examined in an experimental mouse model of DN.
Spec (examined) Gene_expression (expression) of activating transcription factor 3 in primary sensory neurons associated with nervous system injury, diabetes mellitus and diabetic neuropathy
1) Confidence 0.78 Published 2004 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 15574137 Disease Relevance 0.81 Pain Relevance 0.21
At 6 weeks, ATF3 was expressed by neurons among smaller size ranges, but this shift occurred principally within myelinated populations.
Gene_expression (expressed) of ATF3 in neurons
2) Confidence 0.78 Published 2004 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 15574137 Disease Relevance 0.81 Pain Relevance 0.21
Diabetes-induced expression of activating transcription factor 3 in mouse primary sensory neurons.
Gene_expression (expression) of activating transcription factor 3 in primary sensory neurons associated with diabetes mellitus
3) Confidence 0.78 Published 2004 Journal J. Peripher. Nerv. Syst. Section Title Doc Link 15574137 Disease Relevance 0.82 Pain Relevance 0.21
Finally, the ability to detect sensory deficits in diabetic mice occurs after the expression of injury-related gene ATF3, suggesting that nerve damage may be underway prior to the appearance of behavioral deficits.
Gene_expression (expression) of ATF3 in nerve associated with nervous system injury, diabetes mellitus and injury
4) Confidence 0.78 Published 2004 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 15574137 Disease Relevance 1.05 Pain Relevance 0.19
The retrograde labeling of neurons innervating the flank and paw skin using Fluoro-Gold labeled appropriate percentages of ATF3-positive neurons at 3 weeks, suggesting ATF3 is expressed by neurons capable of transporting substances.
Gene_expression (expressed) of ATF3 in skin
5) Confidence 0.78 Published 2004 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 15574137 Disease Relevance 1.08 Pain Relevance 0.27
Diabetes was induced using streptozotocin in C57BL/6 mice, and ATF3 expression in lumbar dorsal root ganglia was assessed at different time points and correlated with the markers of unmyelinated and myelinated neuronal populations.
Gene_expression (expression) of ATF3 in dorsal root ganglia associated with diabetes mellitus and unmyelinated
6) Confidence 0.78 Published 2004 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 15574137 Disease Relevance 0.79 Pain Relevance 0.22
To determine whether diabetes-induced axonal degeneration induces gene expression similar to nerve injury, the expression of activating transcription factor 3 (ATF3) by primary sensory neurons was examined in an experimental mouse model of DN.
Spec (examined) Gene_expression (expression) of ATF3 in primary sensory neurons associated with nervous system injury, diabetes mellitus and diabetic neuropathy
7) Confidence 0.78 Published 2004 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 15574137 Disease Relevance 0.81 Pain Relevance 0.21
Expression of ATF3 in DRG
Gene_expression (Expression) of ATF3
8) Confidence 0.63 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 0.09 Pain Relevance 0.29
Moreover, that occurrence of large areas of fibrosis in mice with a severe phenotype was preceded by large overexpression of Egr1 and Atf3 in these mice and not in mice with a mild phenotype, which have much less fibrosis, confirms our hypothesis that these transcription factors are involved in myocardial rearrangements [10].
Gene_expression (overexpression) of Atf3 associated with fibrosis
9) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824822 Disease Relevance 0.64 Pain Relevance 0.22
The transcription factors Atf3 and Egr1 were exclusively over-expressed in old Scn5a+/?
Gene_expression (expressed) of Atf3
10) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824822 Disease Relevance 1.06 Pain Relevance 0.34
Expression of Activating transcription factor 3 (ATF3) in the L5 DRG was also investigated 7 days after partial ligation of sciatic nerve.
Spec (investigated) Gene_expression (Expression) of Activating transcription factor 3 in sciatic nerve associated with sciatic nerve
11) Confidence 0.54 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 0.58 Pain Relevance 0.60
Expression of Activating transcription factor 3 (ATF3) in the L5 DRG was also investigated 7 days after partial ligation of sciatic nerve.
Spec (investigated) Gene_expression (Expression) of ATF3 in sciatic nerve associated with sciatic nerve
12) Confidence 0.54 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 0.58 Pain Relevance 0.60
III tubulin and anti ATF3 antibody were counted.
Gene_expression (antibody) of ATF3
13) Confidence 0.54 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 0.15 Pain Relevance 0.17
Microglial activation in spinal cord is attenuated in ephrin-B2 CKO mutant mice, but GFAP and ATF3 immunoreactivity are normal in DRG
Gene_expression (immunoreactivity) of ATF3 in spinal cord associated with targeted disruption and spinal cord
14) Confidence 0.54 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 0.66 Pain Relevance 0.39
In the present studies the Seltzer neuropathic pain models showed deficits in the absence of ephrin-B2, although this was not reflected in ATF3 expressing damaged cells, providing further support to the hypothesis that ephrin-B2 present in DRG cells signals to postsynaptic neurons to induce neuropathic pain.
Gene_expression (expressing) of ATF3 in neurons associated with eae and neuropathic pain
15) Confidence 0.42 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 1.15 Pain Relevance 1.11
Production of hind paw mechanical allodynia, activating transcription factor 3, and calcitonin gene- related peptide (CGRP) were assessed.
Gene_expression (Production) of activating transcription factor 3 in paw
16) Confidence 0.40 Published 2008 Journal Spine Section Body Doc Link 18670336 Disease Relevance 0.14 Pain Relevance 0

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