INT12359

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Context Info
Confidence 0.58
First Reported 1987
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 26
Total Number 27
Disease Relevance 8.16
Pain Relevance 6.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tac1) extracellular region (Tac1) plasma membrane (Tac1)
Anatomy Link Frequency
striatum 4
caudate nucleus 2
caudate-putamen 2
putamen 2
plasma 1
Tac1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 20 100.00 Very High Very High Very High
dopamine receptor 4 99.98 Very High Very High Very High
nMDA receptor antagonist 2 99.84 Very High Very High Very High
qutenza 24 99.78 Very High Very High Very High
Dorsal horn 6 99.78 Very High Very High Very High
Enkephalin 26 99.36 Very High Very High Very High
dexamethasone 1 97.96 Very High Very High Very High
Inflammation 2 96.76 Very High Very High Very High
Dopamine 125 96.36 Very High Very High Very High
nMDA receptor 3 95.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 8 100.00 Very High Very High Very High
Parkinson's Disease 54 99.82 Very High Very High Very High
Dyskinesias 48 97.88 Very High Very High Very High
INFLAMMATION 3 96.76 Very High Very High Very High
Injury 2 94.58 High High
Hyperalgesia 6 92.92 High High
Stress 1 87.88 High High
Pharyngitis 3 79.76 Quite High
Neuropathic Pain 2 75.00 Quite High
Causalgia 1 73.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The level of PPT mRNA in the striatum was also decreased in response to ADX, but there were no significant diurnal changes in the expression of the PPT mRNA either in the intact or in the ADX animals.
Negative_regulation (decreased) of PPT mRNA in striatum
1) Confidence 0.58 Published 1991 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1645434 Disease Relevance 0.09 Pain Relevance 0.04
NMDA receptor antagonist MK-801 down-regulates rat striatal proenkephalin and protachykinin mRNAs.
Negative_regulation (down-regulates) of protachykinin associated with nmda receptor antagonist
2) Confidence 0.57 Published 1996 Journal Neurochem. Int. Section Title Doc Link 8719708 Disease Relevance 0 Pain Relevance 0.24
In situ hybridization revealed that BDNF exacerbated the lesion-induced up-regulation of preproenkephalin (PPE) mRNA, and completely reversed the lesion-induced decrease of preprotachykinin (PPT) mRNA.
Negative_regulation (decrease) of PPT
3) Confidence 0.45 Published 1994 Journal Neuroreport Section Abstract Doc Link 8025254 Disease Relevance 0 Pain Relevance 0.20
Using quantitative in situ hybridization, a significant decrease in expression of proenkephalin (27.1%) and of protachykinin mRNAs (20.0%) is observed in the rat caudate-putamen 14 days after daily intraperitoneal administration of N-methyl-D-aspartate receptor antagonist MK-801, 2 mg/kg.
Negative_regulation (decrease) of protachykinin in caudate-putamen associated with antagonist and nmda receptor
4) Confidence 0.42 Published 1996 Journal Neurochem. Int. Section Abstract Doc Link 8719708 Disease Relevance 0 Pain Relevance 0.13
Injury-induced changes in PPT mRNA expression by affected DRG neurons included: (1) at early postoperative times, generally increased levels of PPT mRNA associated with small and intermediate-size B cells exhibiting normal morphology, (2) at late postoperative times, markedly decreased levels of PPT mRNA associated with degenerating B cells, and (3) induction of PPT gene expression by large A cells which is highly correlated with degenerative morphological changes.
Negative_regulation (decreased) of PPT mRNA in neurons associated with injury
5) Confidence 0.42 Published 1994 Journal Pain Section Abstract Doc Link 7816489 Disease Relevance 0.47 Pain Relevance 0.36
In contrast, the tachykinin decreased the rate of alkalinization in rats subjected to elevated intraluminal pressure and treated with indomethacin.
Negative_regulation (decreased) of tachykinin
6) Confidence 0.41 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9655689 Disease Relevance 0 Pain Relevance 0.25
Two months following bilateral 6-hydroxydopamine (6-OHDA) lesion, PPT mRNA levels decreased 59-73% across dorsal subregions of the rostral and caudal striatum while PPE transcripts increased 61-94%.
Negative_regulation (decreased) of PPT mRNA in striatum
7) Confidence 0.39 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11483243 Disease Relevance 0 Pain Relevance 0.45
We have investigated the effect of dopamine receptor blockade on striatal proenkephalin mRNA and protachykinin mRNA by Northern gel analysis and by in situ hybridization histochemistry.
Spec (investigated) Negative_regulation (blockade) of protachykinin associated with dopamine receptor
8) Confidence 0.38 Published 1987 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 3434462 Disease Relevance 0 Pain Relevance 0.16
Chronic haloperidol treatment resulted in a 3.5 fold increase in striatal proenkephalin mRNA and a 30% decrease in protachykinin mRNA (no apparent change in alpha-tubulin mRNA was observed).
Negative_regulation (decrease) of protachykinin
9) Confidence 0.38 Published 1987 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 3434462 Disease Relevance 0 Pain Relevance 0.16
These results are consistent with previous reports of lesion-induced increases in Nmu [44], Nts [45], [46] and Tac2 [47] as well as decreases in Tac1 [18], [48].
Negative_regulation (decreases) of Tac1
10) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001483 Disease Relevance 0 Pain Relevance 0.31
Proenkephalin mRNA levels were increased relative to control values by 107, 88 and 94% and protachykinin mRNA levels decreased by 17, 28 and 10% in the rostral, medial and caudal aspects of the caudate-putamen, respectively.
Negative_regulation (decreased) of protachykinin mRNA in caudate-putamen
11) Confidence 0.35 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1968844 Disease Relevance 0 Pain Relevance 0
Unilateral genitofemoral nerve section induced a loss of CGRP- or tachykinin- and an increase of galanin-immunoreactive cells in the ipsilateral L1/L2 ganglia.
Negative_regulation (loss) of tachykinin in ganglia
12) Confidence 0.27 Published 1990 Journal Brain Res. Section Abstract Doc Link 1693868 Disease Relevance 0.15 Pain Relevance 0.23
Following 6-OHDA, PPT mRNA levels were depressed 60-66% across three subregions of the A-STR and 52-59% across two subregions of the P-STR, while PPE mRNA expression was elevated in both the A-STR (50-62%) and P-STR (55-82%).
Negative_regulation (depressed) of PPT in STR
13) Confidence 0.25 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11000480 Disease Relevance 0 Pain Relevance 0.57
Gonadotropins decrease tachykinin concentrations in the ovary.
Negative_regulation (decrease) of tachykinin in ovary
14) Confidence 0.24 Published 2006 Journal Peptides Section Abstract Doc Link 16165249 Disease Relevance 0 Pain Relevance 0.28
Capsaicin induced a loss of CGRP- and tachykinin-immunoreactive ganglion cells and of CGRP, tachykinin or galanin immunoreactivity from the dorsal horn.
Negative_regulation (loss) of tachykinin in ganglion cells associated with ganglion cysts, qutenza and dorsal horn
15) Confidence 0.23 Published 1990 Journal Brain Res. Section Abstract Doc Link 1693868 Disease Relevance 0.16 Pain Relevance 0.26
In the ipsilateral L1/L2 dorsal horn, CGRP and tachykinin, but not galanin, immunoreactivity was reduced.
Negative_regulation (reduced) of tachykinin in dorsal horn associated with dorsal horn
16) Confidence 0.23 Published 1990 Journal Brain Res. Section Abstract Doc Link 1693868 Disease Relevance 0.15 Pain Relevance 0.25
FK224, a dual antagonist of tachykinin NK1 and NK2 receptors, and FK888, a selective antagonist of NK1 receptor, significantly inhibited capsaicin-induced plasma exudation in the pharynx. 4.
Negative_regulation (antagonist) of tachykinin NK1 in plasma associated with qutenza and antagonist
17) Confidence 0.21 Published 1998 Journal Gen. Pharmacol. Section Abstract Doc Link 9457490 Disease Relevance 0.35 Pain Relevance 0.75
Endogenous tachykinin depletion with capsaicin (1 microM) also significantly attenuated responses to venom (4 micrograms/ml) in GPI.
Negative_regulation (depletion) of tachykinin in GPI associated with qutenza
18) Confidence 0.12 Published 1996 Journal Toxicon Section Abstract Doc Link 8783449 Disease Relevance 0.09 Pain Relevance 0.35
However, it had no effect on the decrease in PPT or PPE-B mRNA.
Negative_regulation (decrease) of PPT
19) Confidence 0.11 Published 2002 Journal Neuroscience Section Abstract Doc Link 12453478 Disease Relevance 1.01 Pain Relevance 0.13
MPTP-induced destruction of the nigro-striatal pathway markedly increased the level of PPE-A mRNA in the caudate nucleus and putamen and decreased the levels of PPT and PPE-B mRNA relative to normal animals.
Negative_regulation (decreased) of PPT in putamen associated with parkinson's disease
20) Confidence 0.11 Published 2002 Journal Neuroscience Section Abstract Doc Link 12453478 Disease Relevance 1.05 Pain Relevance 0.08

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