INT123622

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.51
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Vcp) cytosol (Vcp) transport (Vcp)
endoplasmic reticulum (Vcp) ATPase activity (Vcp) nucleus (Vcp)
Anatomy Link Frequency
embryos 1
blood vessel 1
Vcp (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 3 98.40 Very High Very High Very High
addiction 3 86.44 High High
anesthesia 5 84.40 Quite High
Eae 10 5.00 Very Low Very Low Very Low
Hippocampus 8 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 64 98.00 Very High Very High Very High
Embryonic Lethality 2 97.76 Very High Very High Very High
Targeted Disruption 264 96.24 Very High Very High Very High
Increased Venous Pressure Under Development 5 96.24 Very High Very High Very High
Disease 116 93.56 High High
Lifespan 10 83.68 Quite High
Pulmonary Hypertension 16 82.00 Quite High
Cv Unclassified Under Development 21 80.80 Quite High
Muscle Weakness 34 80.08 Quite High
Systemic Sclerosis 31 74.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The technically simple feeding RNAi protocol has enabled a number of candidate genes (e.g., hda-1, hda-4, sir-2.1, hipr-1, cdc-48.1,2 and dpr-1) to be implicated in in vivo polyQ toxicity.
Negative_regulation (number) of cdc-48 associated with toxicity
1) Confidence 0.42 Published 2009 Journal Mol Neurodegener Section Body Doc Link PMC2762972 Disease Relevance 0.86 Pain Relevance 0.04
In contrast, hemizygotes lacking one VCP allele were apparently indistinguishable from their wild-type littermates.
Negative_regulation (lacking) of VCP allele
2) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950155 Disease Relevance 0.38 Pain Relevance 0
Targeted homozygous deletion of VCP by Cre-loxP technology was reported to result in early embryonic lethality [30] suggesting an important role for the intact VCP expression in the development of mouse embryos.
Negative_regulation (deletion) of VCP in embryos associated with embryonic lethality
3) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950155 Disease Relevance 0.37 Pain Relevance 0
We hypothesized that alpha-adrenergic-mediated contractile dysfunction is mediated through protein kinase C phosphorylation of troponin I, which in in vitro experiments has been shown to reduce actomyosin Mg-ATPase activity.
Negative_regulation (reduce) of actomyosin Mg-ATPase associated with kinase c
4) Confidence 0.09 Published 2005 Journal J. Appl. Physiol. Section Abstract Doc Link 15579573 Disease Relevance 0.16 Pain Relevance 0.25
Thus, a reduced PETCO2 at the AT or VCP is a valuable marker of blood vessel loss, and may be sensitive in detecting early pulmonary vascular disease.
Negative_regulation (reduced) of VCP in blood vessel associated with increased venous pressure under development
5) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001444 Disease Relevance 0.74 Pain Relevance 0

General Comments

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