INT123733

From wiki-pain
Revision as of 14:48, 21 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 2004
Last Reported 2005
Negated 2
Speculated 2
Reported most in Body
Documents 5
Total Number 15
Disease Relevance 12.34
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Fhit) plasma membrane (Fhit) nucleus (Fhit)
cytoplasm (Fhit)
Anatomy Link Frequency
epithelium 3
urinary bladder 1
Fhit (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 15 89.12 High High
cva 10 42.04 Quite Low
medulla 20 37.48 Quite Low
pain flank 10 25.80 Quite Low
Inflammation 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Renal Cancer 50 100.00 Very High Very High Very High
Cancer 490 99.84 Very High Very High Very High
Carcinoma 350 99.82 Very High Very High Very High
Bladder Cancer 20 99.40 Very High Very High Very High
Renal Cell Carcinoma 130 99.04 Very High Very High Very High
Non-genital Cutaneous Warts 5 97.88 Very High Very High Very High
Transitional Cell Carcinoma 40 96.48 Very High Very High Very High
Apoptosis 45 95.80 Very High Very High Very High
INFLAMMATION 15 88.92 High High
Reprotox - General 1 20 86.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expressions of FHIT and survivin in normal urinary bladder epithelium and in bladder cancers were determined by immunohistochemical analysis.
Spec (determined) Gene_expression (expressions) of FHIT in epithelium associated with bladder cancer
1) Confidence 0.78 Published 2005 Journal Carcinogenesis Section Abstract Doc Link 15591090 Disease Relevance 0.71 Pain Relevance 0
FHIT was expressed at high levels in normal epithelium, but was minimally expressed in cancers, and even showed decreased expression in papillomas.
Gene_expression (expressed) of FHIT in epithelium associated with non-genital cutaneous warts and cancer
2) Confidence 0.78 Published 2005 Journal Carcinogenesis Section Abstract Doc Link 15591090 Disease Relevance 0.68 Pain Relevance 0
4-Hydroxybutyl(butyl)nitrosamine-induced urinary bladder cancers in mice: characterization of FHIT and survivin expression and chemopreventive effects of indomethacin.
Gene_expression (expression) of FHIT in urinary bladder associated with bladder cancer
3) Confidence 0.78 Published 2005 Journal Carcinogenesis Section Title Doc Link 15591090 Disease Relevance 0.41 Pain Relevance 0.26
FHIT was expressed at high levels in normal epithelium, but was minimally expressed in cancers, and even showed decreased expression in papillomas.
Gene_expression (expressed) of FHIT in epithelium associated with non-genital cutaneous warts and cancer
4) Confidence 0.78 Published 2005 Journal Carcinogenesis Section Abstract Doc Link 15591090 Disease Relevance 0.69 Pain Relevance 0
FHIT and survivin expressions were similar in cancers from indomethacin-treated and non-treated mice.
Gene_expression (expressions) of FHIT associated with cancer
5) Confidence 0.68 Published 2005 Journal Carcinogenesis Section Abstract Doc Link 15591090 Disease Relevance 0.74 Pain Relevance 0
The same authors described a correlation between reduced Fhit expression and 3p allelic loss in renal carcinomas, particularly in CDCs [28].
Gene_expression (expression) of Fhit associated with renal cell carcinoma
6) Confidence 0.60 Published 2004 Journal BMC Urol Section Body Doc Link PMC517938 Disease Relevance 1.20 Pain Relevance 0
Reduction of Fhit protein expression did not correlate with any of the clinicopathological features of the tumors.
Gene_expression (expression) of Fhit protein associated with cancer
7) Confidence 0.60 Published 2004 Journal BMC Urol Section Body Doc Link PMC517938 Disease Relevance 0.65 Pain Relevance 0
Reduction of Fhit protein expression as consequence of alteration of the FHIT gene has been observed by immunohistochemistry in many types of cancers [26,27].
Gene_expression (expression) of Fhit protein associated with cancer
8) Confidence 0.60 Published 2004 Journal BMC Urol Section Body Doc Link PMC517938 Disease Relevance 1.13 Pain Relevance 0
Fhit expression
Gene_expression (expression) of Fhit
9) Confidence 0.60 Published 2004 Journal BMC Urol Section Body Doc Link PMC517938 Disease Relevance 0.62 Pain Relevance 0
In order to gain an insight into the biology of this tumor we evaluated the expression of five genes involved in the development of renal cancer (FEZ1/LZTS1, FHIT, TP53, P27kip1, and BCL2).


Gene_expression (expression) of FHIT associated with cancer and renal cancer
10) Confidence 0.47 Published 2004 Journal BMC Urol Section Abstract Doc Link PMC517938 Disease Relevance 0.72 Pain Relevance 0
To improve our understanding of the biology of CDC and to explore the possibility that different genes may be involved in the etiology and prognosis of this neoplasm, we analyzed by immunohistochemistry eleven cases of CDC for the expression of five genes (Fez1, Fhit, p53, p27, and bcl2) often involved in the development of many common cancers.
Spec (analyzed) Gene_expression (expression) of Fhit associated with cancer and carcinoma
11) Confidence 0.47 Published 2004 Journal BMC Urol Section Body Doc Link PMC517938 Disease Relevance 1.13 Pain Relevance 0
Here, we have reported the results of our immunohistochemical analysis of the expression of five genes (FEZ1, FHIT, P53, P27kip1, and BCL2) in a relatively large series of CDCs (eleven cases), considering the rarity of this tumor.
Gene_expression (expression) of FHIT associated with cancer
12) Confidence 0.47 Published 2004 Journal BMC Urol Section Body Doc Link PMC517938 Disease Relevance 1.16 Pain Relevance 0
While in our study Fhit inactivation does not seem to be a common event in CDC, an involvement of the FHIT gene in tumorigenesis of this rare tumor cannot be excluded.
Gene_expression (inactivation) of Fhit associated with cancer and carcinoma
13) Confidence 0.46 Published 2004 Journal BMC Urol Section Body Doc Link PMC517938 Disease Relevance 1.16 Pain Relevance 0
Fhit protein was absent in three cases (27%).
Neg (absent) Gene_expression (absent) of Fhit protein
14) Confidence 0.41 Published 2004 Journal BMC Urol Section Abstract Doc Link PMC517938 Disease Relevance 0.72 Pain Relevance 0
Fhit protein was absent in three of eleven cases (27%), and the remaining eight showed diffuse immunoreactivity (Figure 1C).
Neg (absent) Gene_expression (absent) of Fhit protein
15) Confidence 0.41 Published 2004 Journal BMC Urol Section Body Doc Link PMC517938 Disease Relevance 0.61 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox