INT123873

Context Info Confidence 0.50 First Reported 2004 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 7 Total Number 7 Disease Relevance 2.86 Pain Relevance 1.86

cytosol (Cat) mitochondrion (Cat) oxidoreductase activity (Cat) Golgi apparatus (Cat) endoplasmic reticulum (Cat) plasma membrane (Cat)

Anatomy Link Frequency plasma 2 Brain 2 Cat (Mus musculus)

Pain Link Frequency Relevance Heat opioid receptor 2 100.00 Paracetamol 8 98.56 Inflammation 48 97.12 Eae 11 96.44 analgesia 4 95.16 Analgesic 5 94.44 Endogenous opioid 4 89.28 tail-flick 7 86.84 Antinociceptive 2 64.24 antinociception 4 51.80

Disease Link Frequency Relevance Heat Stress 63 99.70 INFLAMMATION 46 97.12 Body Weight 7 96.48 Anxiety Disorder 18 94.72 Injury 4 93.08 Hepatotoxicity 1 87.88 Neurodegenerative Disease 2 58.56 Cancer 1 57.68 Necrosis 1 57.20 Sprains And Strains 22 57.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

CONCLUSIONS: This study shows that the inhibition of brain catalase increases ethanol-induced plasma corticosterone levels.

Positive_regulation (increases) of Negative_regulation (inhibition) of catalase in plasma

1) Confidence 0.50 Published 2004 Journal Alcohol. Clin. Exp. Res. Section Body Doc Link 15608607 Disease Relevance 0 Pain Relevance 0

Brain catalase activity inhibition as well as opioid receptor antagonism increases ethanol-induced HPA axis activation.

Positive_regulation (increases) of Negative_regulation (inhibition) of catalase in Brain associated with opioid receptor

2) Confidence 0.50 Published 2004 Journal Alcohol. Clin. Exp. Res. Section Title Doc Link 15608607 Disease Relevance 0 Pain Relevance 0.22

Biochemically, alprazolam pretreatment decreased malondialdehyde, nitrite activity and restored reduced glutathione level and catalase activity.

Positive_regulation (restored) of Negative_regulation (reduced) of catalase

3) Confidence 0.47 Published 2007 Journal Pharmacol Rep Section Abstract Doc Link 17652828 Disease Relevance 0.66 Pain Relevance 0.31

Biochemically, quercetin treatment attenuated malondialdehyde accumulation and nitrite activity and restored the depleted reduced glutathione and catalase activity.

Positive_regulation (restored) of Negative_regulation (reduced) of catalase

4) Confidence 0.47 Published 2008 Journal J Med Food Section Abstract Doc Link 18800893 Disease Relevance 0.53 Pain Relevance 0.25

6-hr acute restraint stress significantly increased malondialdehyde, nitrite concentration, depleted reduced glutathione and catalase activity as compared to unstressed (naïve) animals (Table 2).

Positive_regulation (increased) of Negative_regulation (depleted) of catalase associated with stress

5) Confidence 0.45 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2882899 Disease Relevance 0.70 Pain Relevance 0.32

This suggests that i) 1% DSS model leads to a significant decrease of catalase activity in digestive contents; ii) Lb. casei BL23 exerts natural anti-inflammatory effects by still unknown mechanisms and that iii) the delivery of MnKat catalase has no effect on the development of inflammation in the tested conditions.

Positive_regulation (leads) of Negative_regulation (decrease) of catalase associated with inflammation

6) Confidence 0.42 Published 2007 Journal Microb Cell Fact Section Body Doc Link PMC1949835 Disease Relevance 0.41 Pain Relevance 0.18

Acetaminophen treatment significantly depleted hepatic GSH and ascorbic acid levels, increased hepatic level of malonyldialdehyde (MDA), reactive oxygen species (ROS), and oxidized glutathione (GSSG), as well as decreased hepatic activity of glutathione peroxidase (GPX), catalase, and superoxide dismutase (SOD) (P < 0.05).

Positive_regulation (increased) of Negative_regulation (decreased) of catalase associated with paracetamol

7) Confidence 0.26 Published 2009 Journal J. Food Sci. Section Abstract Doc Link 19799668 Disease Relevance 0.56 Pain Relevance 0.58

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