INT123926

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Context Info
Confidence 0.54
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 28
Total Number 29
Disease Relevance 21.74
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Angpt1) signal transduction (Angpt1) extracellular space (Angpt1)
extracellular region (Angpt1) plasma membrane (Angpt1) molecular_function (Angpt1)
Anatomy Link Frequency
myocardium 5
monocyte 2
vessels 2
bone marrow 1
blood 1
Angpt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 320 97.00 Very High Very High Very High
ischemia 87 89.56 High High
Central nervous system 3 85.92 High High
Angina 22 82.32 Quite High
cytokine 61 81.48 Quite High
metalloproteinase 3 80.52 Quite High
Inflammation 34 71.52 Quite High
chemokine 2 65.00 Quite High
anesthesia 3 59.00 Quite High
Serotonin 12 55.44 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 1953 99.68 Very High Very High Very High
Myocardial Infarction 1467 99.58 Very High Very High Very High
Pulmonary Hypertension 308 99.34 Very High Very High Very High
Fibrosis 341 98.00 Very High Very High Very High
Ventricular Remodeling 210 96.60 Very High Very High Very High
Apoptosis 74 95.60 Very High Very High Very High
Infarction 33 92.56 High High
Coronary Artery Disease 105 89.56 High High
Stress 47 88.72 High High
Congenital Anomalies 2 84.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our treatment strategy leading to the coexpression of VEGF and Ang-1 might have led to the increased expression of survivin through the activation of NF?
Gene_expression (coexpression) of Ang-1
1) Confidence 0.54 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 0.82 Pain Relevance 0.10
We observed significant reduction in the expression of VEGF and Ang-1 in the diabetic myocardium.
Gene_expression (expression) of Ang-1 in myocardium associated with diabetes mellitus
2) Confidence 0.54 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 1.01 Pain Relevance 0.07
A strategy to locally overexpress VEGF and Ang-1 in combination would prove beneficial because, although VEGF can take the lead in the process of neovascularization, Ang-1 would be expected to support the maturation of the newly formed vessels.
Gene_expression (overexpress) of Ang-1 in vessels
3) Confidence 0.54 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 0.83 Pain Relevance 0.06
Similarly, we observed a significant increase in the expression of Ang-1 (4.0-fold) and Tie-2 (2.1-fold) in the diabetic animals that received the therapy (DVAMI), 4 days after the treatment, compared with the Ad.LacZ-treated diabetic MI (DLZMI) group (Fig. 4C and D).


Gene_expression (expression) of Ang-1 associated with diabetes mellitus and myocardial infarction
4) Confidence 0.54 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 1.00 Pain Relevance 0
In the present study, we observed a significant reduction in the expression of Ang-1 (2.2-fold) and Tie-2 (3.1-fold) 4 days after the surgical procedure, in the DS-operated animals compared with CS-operated animals (Fig. 4A and B).
Gene_expression (expression) of Ang-1
5) Confidence 0.54 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 0.90 Pain Relevance 0
Moreover, there is evidence that suggests that post-MI vascular repair is not dependent solely on the activation and participation of resident endothelial cells, but may also reflect an increased bone marrow–derived endothelial progenitor cell mobilization and homing, which are in turn activated by overexpression of both VEGF and Ang-1 (43,44).
Gene_expression (overexpression) of Ang-1 in bone marrow associated with myocardial infarction
6) Confidence 0.54 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 0.84 Pain Relevance 0.03
In our present study, the strategy of combination gene therapy markedly increased the expression of VEGF and Ang-1 in the diabetic ischemic heart compared with the Ad.LacZ-treated diabetic MI group.
Gene_expression (expression) of Ang-1 in heart associated with diabetes mellitus and myocardial infarction
7) Confidence 0.54 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 1.14 Pain Relevance 0.04
Effect of gene therapy on the expression of Ang-1 and Tie-2.
Gene_expression (expression) of Ang-1
8) Confidence 0.54 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 0.86 Pain Relevance 0
The cooperative effect of VEGF and Ang-1 coexpression and the increase in the expression of their respective receptors due to the therapy in mediating neovascularization were confirmed by a marked increase in the capillary density and arteriolar density in the DVAMI group compared with the Ad.LacZ-treated diabetic MI group.
Gene_expression (coexpression) of Ang-1 in capillary associated with diabetes mellitus and myocardial infarction
9) Confidence 0.54 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 0.89 Pain Relevance 0.08
Molecular basis for the angiogenic and cardioprotective effect of VEGF–Ang-1 therapy in the diabetic ischemic myocardium
Gene_expression (therapy) of Ang-1 in myocardium associated with diabetes mellitus
10) Confidence 0.47 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 1.13 Pain Relevance 0
A strategy to locally overexpress VEGF and Ang-1 in combination would prove beneficial because, although VEGF can take the lead in the process of neovascularization, Ang-1 would be expected to support the maturation of the newly formed vessels.
Gene_expression (expected) of Ang-1 in vessels
11) Confidence 0.47 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 0.94 Pain Relevance 0.07
Immediately after MI, adenoviral vectors encoding for VEGF (Ad.VEGF, 6 × 107 pfu) and Ang-1 (Ad.Ang1, 1.5 × 105 pfu) were intramyocardially administered in combination (in 100 ?
Gene_expression (encoding) of Ang-1 associated with myocardial infarction
12) Confidence 0.47 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 0.71 Pain Relevance 0
B in the diabetic ischemic myocardium, thereby confirming improvement in the angiogenic signaling mechanism associated with increase in the expression of VEGF and Ang-1 and phosphorylation of MK2.
Gene_expression (expression) of Ang-1 in myocardium associated with diabetes mellitus
13) Confidence 0.42 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 0.72 Pain Relevance 0.07
There was a decrease in the expression of VEGF and Ang-1 in the DS compared with CS (Fig. 1B and C).
Gene_expression (expression) of Ang-1
14) Confidence 0.42 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 0.37 Pain Relevance 0
We also observed increased phosphorylated mitogen-activated protein kinase–activated protein kinase-2, 2 days after the treatment and increased expression of vascular endothelial growth factor (VEGF), Flk-1, angiopoietin-1 (Ang-1), Tie-2, and survivin, 4 days after treatment in the diabetic animals.
Gene_expression (expression) of Ang-1 associated with diabetes mellitus
15) Confidence 0.42 Published 2010 Journal Diabetes Section Abstract Doc Link PMC2797944 Disease Relevance 1.20 Pain Relevance 0.07
The MI induced by left anterior descending artery (LAD) occlusion seemed to trigger the expression of VEGF and Ang-1 in the nondiabetic control (CLZMI) animals to which Ad.LacZ was administered.
Gene_expression (expression) of Ang-1 in artery associated with myocardial infarction
16) Confidence 0.42 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 0.52 Pain Relevance 0.03
We also observed increased phosphorylated mitogen-activated protein kinase–activated protein kinase-2, 2 days after the treatment and increased expression of vascular endothelial growth factor (VEGF), Flk-1, angiopoietin-1 (Ang-1), Tie-2, and survivin, 4 days after treatment in the diabetic animals.
Gene_expression (expression) of angiopoietin-1 associated with diabetes mellitus
17) Confidence 0.42 Published 2010 Journal Diabetes Section Abstract Doc Link PMC2797944 Disease Relevance 1.20 Pain Relevance 0.07
The therapy significantly reduced the ventricular remodeling as evidenced by the significant reduction in the collagenous fibrotic tissue and improvement in the myocardial functions in conjunction with significant increase in the levels of VEGF and its receptor Flk-1, Ang-1 and its receptor Tie-2, p-MK2, and antiapoptotic survivin.
Gene_expression (levels) of Ang-1 associated with fibrosis and ventricular remodeling
18) Confidence 0.42 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 1.15 Pain Relevance 0.03
Biological effects of coexpression of VEGF and Ang-1 in the diabetic ischemic myocardium
Gene_expression (coexpression) of Ang-1 in myocardium associated with diabetes mellitus
19) Confidence 0.42 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 0.83 Pain Relevance 0.15
Similarly, the expression of VEGF and Ang-1 was restored markedly upon treatment in the diabetic (DVAMI) myocardium (Fig. 1B and C).


Gene_expression (expression) of Ang-1 in myocardium associated with diabetes mellitus
20) Confidence 0.42 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 0.78 Pain Relevance 0.11

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