INT123960

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Context Info
Confidence 0.43
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.48
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Hspb1) cytoskeleton (Hspb1) nucleus (Hspb1)
intracellular (Hspb1) response to stress (Hspb1) cytoplasm (Hspb1)
Anatomy Link Frequency
smooth muscle 2
heart 2
Hspb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 1 98.02 Very High Very High Very High
Morphine 2 83.84 Quite High
Enkephalin 1 74.92 Quite High
Dismenorea 1 74.88 Quite High
isoflurane 2 62.80 Quite High
COX-2 inhibitor 1 56.60 Quite High
Angina 3 36.76 Quite Low
agonist 1 7.92 Low Low
ischemia 25 5.00 Very Low Very Low Very Low
tolerance 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 4 100.00 Very High Very High Very High
Dysmenorrhea 1 74.88 Quite High
Aging 18 70.64 Quite High
Infarction 2 38.00 Quite Low
Cv General 3 Under Development 3 36.76 Quite Low
Myocardial Infarction 5 17.76 Low Low
Cv Unclassified Under Development 24 5.00 Very Low Very Low Very Low
Reperfusion Injury 21 5.00 Very Low Very Low Very Low
Coronary Artery Disease 10 5.00 Very Low Very Low Very Low
Parkinson's Disease 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since phosphorylation of Hsp27 has been reported to be a prerequisite for smooth muscle contraction, we examined the temporal and spatial expression of Ser-15 phosphorylated Hsp27.
Negative_regulation (prerequisite) of Phosphorylation (phosphorylation) of Hsp27 in smooth muscle
1) Confidence 0.43 Published 2005 Journal Reproduction Section Abstract Doc Link 15615903 Disease Relevance 0.31 Pain Relevance 0.07
Coupling between the opioid receptor and p38 MAPK (mitogen-activated protein kinase) was shown to be lost in the aged mouse heart, and phosphorylation of the downstream protein HSP27 (Heat shock protein 27) was reduced [52,53].


Negative_regulation (reduced) of Phosphorylation (phosphorylation) of HSP27 in heart associated with shock and opioid receptor
2) Confidence 0.15 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872846 Disease Relevance 0.17 Pain Relevance 0.35

General Comments

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