INT124099

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Context Info
Confidence 0.00
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.34
Pain Relevance 1.26

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nucleoplasm (RYBP) small molecule metabolic process (GGT5) intracellular (RYBP)
DNA binding (RYBP) transferase activity, transferring acyl groups (GGT5) cytoplasm (RYBP)
GGT5 (Homo sapiens)
RYBP (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 23 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nephrotoxicity 5 100.00 Very High Very High Very High
Injury 2 51.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings are consistent with the hypothesis that APAP-CYS contributes to APAP nephrotoxicity by depletion of renal GSH stores through interaction with the gamma-glutamyl cycle.
gamma-glutamyl Binding (interaction) of APAP-CYS associated with nephrotoxicity and paracetamol
1) Confidence 0.00 Published 2005 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 15629191 Disease Relevance 0.34 Pain Relevance 1.26

General Comments

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