INT12410

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Context Info
Confidence 0.29
First Reported 1985
Last Reported 1997
Negated 0
Speculated 1
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 3.49
Pain Relevance 3.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein folding (Ahsp) cytoplasm (Ahsp)
Anatomy Link Frequency
endothelium 3
aorta 1
vasculature 1
arterioles 1
mesenteric artery 1
Ahsp (Mus musculus)
Pain Link Frequency Relevance Heat
depression 4 99.32 Very High Very High Very High
Clonidine 14 97.92 Very High Very High Very High
adenocard 3 97.64 Very High Very High Very High
agonist 8 97.06 Very High Very High Very High
Angina 28 94.32 High High
tetrodotoxin 5 85.96 High High
sodium channel 3 85.12 High High
antagonist 2 81.24 Quite High
tolerance 4 79.12 Quite High
ischemia 3 34.16 Quite Low
Disease Link Frequency Relevance Heat
Depression 4 99.32 Very High Very High Very High
Coronary Artery Disease 7 98.44 Very High Very High Very High
Syndrome 2 97.44 Very High Very High Very High
Cv General 3 Under Development 25 94.32 High High
Stable Angina Pectoris 2 91.44 High High
Myocardial Infarction 15 84.68 Quite High
Increased Venous Pressure Under Development 12 82.36 Quite High
Thrombosis 2 69.92 Quite High
Hypotension 2 54.08 Quite High
Angina 1 29.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The EDRF inhibitors did not suppress arteriolar dilation to typically applied adenosine (10(-4) M), an endothelium-independent dilator.
Negative_regulation (inhibitors) of EDRF in endothelium associated with adenocard
1) Confidence 0.29 Published 1990 Journal Am. J. Physiol. Section Abstract Doc Link 2337183 Disease Relevance 0 Pain Relevance 0.05
To demonstrate that the rat intestinal and the spinotrapezius muscle arterioles can respond to EDRF, the vessels were dilated by iontophoretically applied acetylcholine (ACh), and this dilation was greatly attenuated by the inhibitors of EDRF actions, methylene blue (100 microM) and dithiothreitol (50 microM).
Negative_regulation (inhibitors) of EDRF in arterioles
2) Confidence 0.29 Published 1990 Journal Am. J. Physiol. Section Abstract Doc Link 2337183 Disease Relevance 0 Pain Relevance 0.04
An inhibitor of endothelium-derived relaxing factor (EDRF) synthase, N omega-nitro-L-arginine methyl ester (L-NAME) (0.65 mM), enhanced the veratridine-induced contraction in rings with an intact endothelium, which suggests that EDRF was being released during the veratridine-induced contraction.
Negative_regulation (inhibitor) of EDRF in endothelium
3) Confidence 0.25 Published 1991 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1667387 Disease Relevance 0 Pain Relevance 0.20
After EDRF inhibition, venular ACh exposure did not cause arteriolar dilation.
Negative_regulation (inhibition) of EDRF
4) Confidence 0.25 Published 1990 Journal Am. J. Physiol. Section Abstract Doc Link 2337183 Disease Relevance 0 Pain Relevance 0.12
The depression of sensitivity to these agonists in rings with endothelium appeared to be due to the vasodepressor action of endothelium-derived relaxing factor (EDRF), as hemoglobin, a specific blocking agent of EDRF, abolished this depression.
Negative_regulation (blocking) of EDRF in endothelium associated with depression and agonist
5) Confidence 0.11 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3009791 Disease Relevance 0.36 Pain Relevance 0.75
The inhibitory effects of endothelium-derived relaxing factor (EDRF) on the contractions induced by norepinephrine and clonidine in rat aorta were examined.
Spec (examined) Negative_regulation (effects) of EDRF in aorta associated with clonidine
6) Confidence 0.08 Published 1985 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 3879308 Disease Relevance 0 Pain Relevance 0.22
Additional efficacy stems from the ability of the nitrates to replenish the deficient endothelium-derived relaxing factor (EDRF), nitric oxide (NO), in patients with coronary heart disease and also to inhibit platelet aggregation.
Negative_regulation (replenish) of EDRF in stems associated with coronary artery disease
7) Confidence 0.08 Published 1997 Journal Cardiovasc Drugs Ther Section Abstract Doc Link 9211013 Disease Relevance 0.36 Pain Relevance 0.17
NTG potentially may act to correct a localized deficiency of EDRF effect, at both the vasculature and platelet levels.
Negative_regulation (deficiency) of EDRF in vasculature
8) Confidence 0.06 Published 1991 Journal Am. J. Med. Section Abstract Doc Link 1928201 Disease Relevance 1.24 Pain Relevance 0.67
In another set of experiments, the ability of captopril to inhibit superoxide-mediated inactivation of EDRF was examined.
Negative_regulation (inactivation) of EDRF
9) Confidence 0.05 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1646324 Disease Relevance 0.22 Pain Relevance 0.06
The PAF- and acetylcholine (ACh)-induced relaxations of mesenteric artery were dependent on the presence of endothelium and were inhibited by either hydroquinone and methylene blue, which inhibit the action of endothelium-derived relaxing factor (EDRF), or L-canavanine, which inhibits the formation of nitric oxide from L-arginine.
Negative_regulation (inhibit) of EDRF in mesenteric artery
10) Confidence 0.04 Published 1990 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2314485 Disease Relevance 0.08 Pain Relevance 0.12
NTG potentially may act to correct a localized deficiency of EDRF effect, at both the vasculature and platelet levels.
Negative_regulation (deficiency) of EDRF in platelet
11) Confidence 0.02 Published 1991 Journal Am. J. Med. Section Abstract Doc Link 1928201 Disease Relevance 1.24 Pain Relevance 0.67

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