INT124121

Context Info Confidence 0.26 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 1.84 Pain Relevance 2.25

extracellular space (IL6, CCL2) aging (IL6, CCL2) extracellular region (IL6, CCL2) signal transduction (CCL2) cell adhesion (CCL2) cytoskeleton organization (CCL2)

Anatomy Link Frequency T cell 2 IL6 (Homo sapiens) CCL2 (Homo sapiens)

Pain Link Frequency Relevance Heat chemokine 2 100.00 Morphine 8 99.44 opioid receptor 2 95.20 antagonist 2 93.92 mu opioid receptor 4 91.88 opiate 14 89.84 Inflammation 4 85.52 cytokine 2 25.00

Disease Link Frequency Relevance Heat INFLAMMATION 4 85.52 Acquired Immune Deficiency Syndrome Or Hiv Infection 20 79.36 Viral Meningitis 2 71.52 Infection 2 66.56 Heroin Dependence 2 62.84

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Moreover, astrocyte cultures treated with morphine and Tat showed exaggerated increases in chemokine release, including monocyte chemoattractant protein-1 (MCP-1) and regulated on activation, normal T cell expressed and secreted (RANTES), as well as interleukin-6 (IL-6).

interleukin-6 Positive_regulation (increases) of MCP-1 in T cell associated with chemokine and morphine

1) Confidence 0.26 Published 2005 Journal Glia Section Abstract Doc Link 15630704 Disease Relevance 0.92 Pain Relevance 1.12

Moreover, astrocyte cultures treated with morphine and Tat showed exaggerated increases in chemokine release, including monocyte chemoattractant protein-1 (MCP-1) and regulated on activation, normal T cell expressed and secreted (RANTES), as well as interleukin-6 (IL-6).

interleukin-6 Positive_regulation (increases) of monocyte chemoattractant protein-1 in T cell associated with chemokine and morphine

2) Confidence 0.26 Published 2005 Journal Glia Section Abstract Doc Link 15630704 Disease Relevance 0.92 Pain Relevance 1.12

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