INT12416

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Context Info
Confidence 0.07
First Reported 1991
Last Reported 2005
Negated 3
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 0.25
Pain Relevance 7.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Atxn2l) biological_process (Atxn2l)
Anatomy Link Frequency
dorsal 1
ventral 1
Atxn2l (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 34 100.00 Very High Very High Very High
agonist 14 100.00 Very High Very High Very High
Delta opioid receptors 12 100.00 Very High Very High Very High
Analgesic 10 100.00 Very High Very High Very High
tolerance 8 100.00 Very High Very High Very High
antagonist 7 99.10 Very High Very High Very High
Morphine 12 99.04 Very High Very High Very High
analgesia 8 97.44 Very High Very High Very High
Opioid 12 96.88 Very High Very High Very High
antinociception 6 96.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 4 87.08 High High
Bordatella Infection 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, morphine potentiated rewarding stimulation in the D2Rwt, had no effect in the D2Rhet, and antagonized rewarding stimulation in the D2Rko mice.
Neg (no) Regulation (effect) of D2Rhet
1) Confidence 0.07 Published 2005 Journal Psychopharmacology (Berl.) Section Body Doc Link 16136297 Disease Relevance 0 Pain Relevance 0
The ODN to Gi3 alpha subunits reduced the effects of the selective agonists of delta opioid receptors, [D-Pen2,5]-enkephalin and [D-Ala2]deltorphin II.
Regulation (effects) of D-Ala2 associated with agonist, enkephalin and delta opioid receptors
2) Confidence 0.05 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8531133 Disease Relevance 0 Pain Relevance 1.34
The ODN to Gi3 alpha subunits reduced the effects of the selective agonists of delta opioid receptors, [D-Pen2,5]-enkephalin and [D-Ala2]deltorphin II.
Regulation (effects) of D-Pen2 associated with agonist, enkephalin and delta opioid receptors
3) Confidence 0.05 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8531133 Disease Relevance 0 Pain Relevance 1.33
Pretreatment with the kappa antagonist, nor-binaltorphimine, at doses shown not to affect [D-Ala2, NMePhe4, Gly-ol]enkephalin- (mu-agonist) or [D-Pen2, D-Pen5]enkephalin (delta-agonist)-induced antinociception, significantly attenuated the effects of U69,593 and bremazocine, suggesting actions of these agonists at kappa receptors.
Neg (not) Regulation (affect) of D-Ala2 associated with antinociception, antagonist, agonist and enkephalin
4) Confidence 0.03 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1646325 Disease Relevance 0 Pain Relevance 0.95
The same antibodies had little effect on [D-Pen2,5]enkephalin (DPDPE) and [D-Ala2]deltorphin II, both agonists at delta-OR.
Neg (little) Regulation (effect) of D-Pen2 associated with agonist, delta opioid receptors and enkephalin
5) Confidence 0.02 Published 1997 Journal Eur. J. Neurosci. Section Abstract Doc Link 9215703 Disease Relevance 0.25 Pain Relevance 1.08
Effect of nitric oxide synthase inhibition on tolerance to the analgesic action of D-Pen2, D-Pen5 enkephalin and morphine in the mouse.
Regulation (tolerance) of D-Pen2 associated with analgesic, tolerance, enkephalin and morphine
6) Confidence 0.01 Published 1996 Journal Neuropeptides Section Title Doc Link 8819145 Disease Relevance 0 Pain Relevance 1.78
Vulnerability to stressor-induced disturbances in self-stimulation from the dorsal and ventral A10 area: differential effects of intraventricular D-Ala2-Met5-enkephalinamide, D-Ala2, N-Me-Phe4, Gly-Ol5-enkephalin, and D-Pen2, D-Pen5-enkephalin administration.
Regulation (effects) of D-Pen2 in ventral associated with enkephalin
7) Confidence 0.01 Published 1998 Journal Brain Res. Bull. Section Title Doc Link 9865856 Disease Relevance 0 Pain Relevance 0.47
Vulnerability to stressor-induced disturbances in self-stimulation from the dorsal and ventral A10 area: differential effects of intraventricular D-Ala2-Met5-enkephalinamide, D-Ala2, N-Me-Phe4, Gly-Ol5-enkephalin, and D-Pen2, D-Pen5-enkephalin administration.
Regulation (effects) of D-Pen2 in dorsal associated with enkephalin
8) Confidence 0.00 Published 1998 Journal Brain Res. Bull. Section Title Doc Link 9865856 Disease Relevance 0 Pain Relevance 0.47

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