INT124212

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Context Info
Confidence 0.21
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 3.48
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CHI3L1) extracellular region (CHI3L1) endoplasmic reticulum (CHI3L1)
proteinaceous extracellular matrix (CHI3L1) carbohydrate metabolic process (CHI3L1) cytoplasm (CHI3L1)
Anatomy Link Frequency
cartilage 3
CHI3L1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 13 94.36 High High
cytokine 1 93.80 High High
Osteoarthritis 24 86.16 High High
rheumatoid arthritis 2 85.68 High High
Disease Link Frequency Relevance Heat
Aids-related Complex 1 99.90 Very High Very High Very High
Apoptosis 9 99.54 Very High Very High Very High
Pain 7 94.36 High High
Osteoarthritis 25 86.16 High High
Rheumatoid Arthritis 2 85.68 High High
Injury 2 84.72 Quite High
Arthralgia 2 83.72 Quite High
Death 4 78.40 Quite High
Disease 1 73.28 Quite High
Arthropathy 1 41.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serum levels of glycoprotein 39 (YKL-40), a marker of cartilage degradation, and insulin-like growth factor-I (IGF-I), a growth factor associated with cartilage synthesis, were assessed at baseline and at the end of the study.
Protein_catabolism (degradation) of YKL-40 in cartilage
1) Confidence 0.21 Published 2004 Journal Phytomedicine Section Abstract Doc Link 15636169 Disease Relevance 0.97 Pain Relevance 0.61
Serum levels of glycoprotein 39 (YKL-40), a marker of cartilage degradation, and insulin-like growth factor-I (IGF-I), a growth factor associated with cartilage synthesis, were assessed at baseline and at the end of the study.
Protein_catabolism (degradation) of glycoprotein 39 in cartilage
2) Confidence 0.19 Published 2004 Journal Phytomedicine Section Abstract Doc Link 15636169 Disease Relevance 0.97 Pain Relevance 0.61
Finally, the regulation of the natural inhibitors of apoptosis (c-FLIP, BAR, ARC and HC-gp39) could complement the other strategies to reduce cartilage degradation.
Protein_catabolism (degradation) of HC-gp39 in cartilage associated with aids-related complex and apoptosis
3) Confidence 0.01 Published 2007 Journal Curr Drug Targets Section Abstract Doc Link 17305511 Disease Relevance 1.54 Pain Relevance 0.18

General Comments

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