INT124297

From wiki-pain
Revision as of 04:44, 23 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.77
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 112
Total Number 113
Disease Relevance 65.65
Pain Relevance 7.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sod2) oxidoreductase activity (Sod2) mitochondrion organization (Sod2)
DNA binding (Sod2) response to stress (Sod2) cytoplasm (Sod2)
Anatomy Link Frequency
bladder 7
blood 6
embryos 4
fibroblasts 3
liver 2
Sod2 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 15 99.80 Very High Very High Very High
Eae 177 99.72 Very High Very High Very High
dorsal root ganglion 27 99.52 Very High Very High Very High
Demyelination 48 99.44 Very High Very High Very High
Spinal cord 36 99.28 Very High Very High Very High
Inflammation 367 99.12 Very High Very High Very High
long-term potentiation 6 98.36 Very High Very High Very High
imagery 596 98.30 Very High Very High Very High
cytokine 250 97.68 Very High Very High Very High
Central nervous system 230 96.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cytomegalovirus Infection 22 99.98 Very High Very High Very High
Targeted Disruption 1439 99.88 Very High Very High Very High
Injury 350 99.76 Very High Very High Very High
Stress 1455 99.74 Very High Very High Very High
Hyperglycemia 1490 99.72 Very High Very High Very High
Diabetic Retinopathy 1 99.62 Very High Very High Very High
Disease 1828 99.60 Very High Very High Very High
Skin Cancer 36 99.52 Very High Very High Very High
Demyelinating Disease 346 99.44 Very High Very High Very High
Cancer 273 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SOD2 overexpression reduces mitochondrial superoxide load.
Gene_expression (overexpression) of SOD2
1) Confidence 0.77 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2956689 Disease Relevance 1.02 Pain Relevance 0.12
Recently, Munusamy and Mac-Millan-Crow [29] reported that overexpression of SOD2 prevented early stage hyperglycemia-induced mitochondrial injury in normal renal rat proximal tubular cells.
Gene_expression (overexpression) of SOD2 in proximal associated with hyperglycemia and injury
2) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956689 Disease Relevance 1.54 Pain Relevance 0.09
For example, SOD2 overexpression in primary dorsal root ganglion cultures or in mice protected cellular injury and prevented development of signs of diabetic neuropathy (DN) respectively [10].
Gene_expression (overexpression) of SOD2 in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, diabetic neuropathy and injury
3) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956689 Disease Relevance 1.31 Pain Relevance 0.10
Last, we hypothesize that reduction of oxidative stress through the overexpression of SOD2 should ameliorate these effects.
Gene_expression (overexpression) of SOD2 associated with stress
4) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956689 Disease Relevance 1.15 Pain Relevance 0.17
To determine if axonal transport deficits were associated with hyperglycemia-induced oxidative stress, we measured axonal transport rates with MEMRI in STZ-treated SOD2 overexpressing mice (SOD2-STZ).
Gene_expression (overexpressing) of SOD2 associated with stress and hyperglycemia
5) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956689 Disease Relevance 0.58 Pain Relevance 0.03
Our results describe restoration of axonal transport rates following SOD2 overexpression in animal models, and although the model we use does not directly correlate with human disease, similar outcome may be possible in diabetic patients, provided optimization of timing, dosage and potency of antioxidant therapy used.
Gene_expression (overexpression) of SOD2 associated with diabetes mellitus, disease and potency
6) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956689 Disease Relevance 1.14 Pain Relevance 0.08
Upon SOD2 overexpression, the deficits in axonal transport recovered in association with restoration of levels of phosphorylated p38 MAPK and tau protein.
Gene_expression (overexpression) of SOD2
7) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956689 Disease Relevance 0.88 Pain Relevance 0.09
Additionally, overexpression of SOD2 reduces symptoms of neuropathy in streptozotocin (STZ) treated C57Bl/6 mice [10].
Gene_expression (overexpression) of SOD2 associated with neuropathic pain
8) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956689 Disease Relevance 1.44 Pain Relevance 0.04
Image analysis at the ROIs demonstrated that ROS levels are significantly increased in hyperglycemic mice as compared to the controls and that these levels normalized back to control levels in STZ-treated SOD2 overexpressing mice, Figure 3B.
Gene_expression (overexpressing) of SOD2
9) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956689 Disease Relevance 0.22 Pain Relevance 0
T1-weighted MEMRI imaging was used to determine axonal transport rates post-streptozotocin injection in wildtype (WT) and superoxide dismutase 2 (SOD2) overexpressing C57Bl/6 mice.
Gene_expression (overexpressing) of SOD2 associated with imagery
10) Confidence 0.77 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2956689 Disease Relevance 0.98 Pain Relevance 0.12
T1-weighted MEMRI imaging was used to determine axonal transport rates post-streptozotocin injection in wildtype (WT) and superoxide dismutase 2 (SOD2) overexpressing C57Bl/6 mice.
Gene_expression (overexpressing) of superoxide dismutase 2 associated with imagery
11) Confidence 0.77 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2956689 Disease Relevance 0.99 Pain Relevance 0.12
Upon overexpression of SOD2, mitochondrial antioxidant enzyme, hyperglycemia-induced oxidative stress-related axonal transport deficits recover.
Gene_expression (overexpression) of SOD2 associated with stress and hyperglycemia
12) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956689 Disease Relevance 1.10 Pain Relevance 0.09
Furthermore, overexpression of SOD2 significantly prevented the development of retinopathy in mice by preventing retina from diabetes-induced oxidative damage [30].
Gene_expression (overexpression) of SOD2 in retina associated with diabetes mellitus and ocular toxicity (including many sub-types)
13) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956689 Disease Relevance 1.57 Pain Relevance 0.09
Whereas hyperglycemia-induced oxidative stress damages peripheral neurons, overexpression of SOD2 reduces the superoxide load and prevents hyperglycemia-induced cellular injury in dorsal root ganglia (DRG) cultures [10].
Gene_expression (overexpression) of SOD2 in dorsal root ganglia associated with stress, hyperglycemia and injury
14) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956689 Disease Relevance 1.39 Pain Relevance 0.06
In this study, we utilized two different animal models: (i) STZ-induced hyperglycemia mice and (ii) a heterozygotic SOD2 overexpressing STZ-treated hyperglycemia mice.
Gene_expression (overexpressing) of SOD2 associated with hyperglycemia
15) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956689 Disease Relevance 0.65 Pain Relevance 0.09
Similarly, SOD2 overexpression in heart mitochondria improved mitochondrial respiration, protected heart morphology, and restored cardiac contractility of a diabetic heart [31].
Gene_expression (overexpression) of SOD2 in heart associated with diabetes mellitus
16) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956689 Disease Relevance 1.71 Pain Relevance 0.08
To confirm the knockdown of Sod2 gene expression, we examined the in vivo consequence of SOD2 deficiency.
Gene_expression (expression) of Sod2
17) Confidence 0.77 Published 2006 Journal PLoS Genet Section Body Doc Link PMC1358942 Disease Relevance 0.31 Pain Relevance 0
After detection of SOD2, the membrane was stripped for 30 min at 55 °C in a buffer containing 100 mM ?
Gene_expression (detection) of SOD2
18) Confidence 0.77 Published 2006 Journal PLoS Genet Section Body Doc Link PMC1358942 Disease Relevance 0.08 Pain Relevance 0
To ensure that the enhanced sensitivity was caused by the knockdown of SOD2 expression, we transduced the fibroblasts with a recombinant adenovirus that expressed a Sod2 gene whose mRNA was resistant to the siRNA expressed by the transgene.
Gene_expression (expression) of SOD2 in fibroblasts
19) Confidence 0.77 Published 2006 Journal PLoS Genet Section Body Doc Link PMC1358942 Disease Relevance 0.67 Pain Relevance 0
Fibroblasts from transgenic line 8 showed a higher sensitivity than the wild-type cells (Figure 2D), consistent with the lowered levels of SOD2 protein in these cells (Figure 2E).
Gene_expression (levels) of SOD2 protein in Fibroblasts associated with targeted disruption
20) Confidence 0.77 Published 2006 Journal PLoS Genet Section Body Doc Link PMC1358942 Disease Relevance 0.61 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox