INT124477

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Context Info
Confidence 0.12
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.35
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MAP2K1, MAPK1) Golgi apparatus (MAP2K1, MAPK1) cytoplasm (MAP2K1, MAPK1)
cytosol (MAP2K1, MAPK1) signal transduction (MAP2K1, MAPK1) nucleus (MAP2K1, MAPK1)
MAP2K1 (Homo sapiens)
MAPK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 8 92.56 High High
COX-2 inhibitor 2 82.36 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 10 96.32 Very High Very High Very High
Colon Cancer 8 75.00 Quite High
Death 2 66.92 Quite High
Polyps 2 54.56 Quite High
INFLAMMATION 2 50.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, MEK/ERK and p38 MAPK activation mediate COX-2 induction by sulindac sulfide.
MEK Positive_regulation (mediate) of Positive_regulation (activation) of ERK
1) Confidence 0.12 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15657353 Disease Relevance 0.68 Pain Relevance 0.33
In conclusion, MEK/ERK and p38 MAPK activation mediate COX-2 induction by sulindac sulfide.
MEK Positive_regulation (mediate) of Positive_regulation (activation) of p38
2) Confidence 0.10 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15657353 Disease Relevance 0.68 Pain Relevance 0.33

General Comments

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