INT12455

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Context Info
Confidence 0.54
First Reported 1981
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 30
Total Number 30
Disease Relevance 5.63
Pain Relevance 10.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adra2a) plasma membrane (Adra2a) cytoplasm (Adra2a)
signal transducer activity (Adra2a)
Anatomy Link Frequency
platelet 2
kidney 2
adipose tissue 2
outflow 1
PC-12 1
Adra2a (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 51 100.00 Very High Very High Very High
agonist 25 100.00 Very High Very High Very High
adenocard 6 100.00 Very High Very High Very High
Opioid 8 99.96 Very High Very High Very High
transcutaneous nerve stimulation 9 99.68 Very High Very High Very High
tricyclic antidepressant 3 99.48 Very High Very High Very High
noradrenaline 3 99.42 Very High Very High Very High
isoflurane 3 99.40 Very High Very High Very High
MU agonist 4 99.28 Very High Very High Very High
withdrawal 3 99.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Obesity 31 100.00 Very High Very High Very High
Targeted Disruption 6 99.96 Very High Very High Very High
Sprains And Strains 2 99.46 Very High Very High Very High
Hepatitis 2 99.32 Very High Very High Very High
Bordatella Infection 8 99.28 Very High Very High Very High
Pheochromocytoma 1 98.84 Very High Very High Very High
Schizophrenia 3 98.38 Very High Very High Very High
Increased Venous Pressure Under Development 4 96.08 Very High Very High Very High
Apnoea 1 96.08 Very High Very High Very High
Depressive Disorder 1 95.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results of this study indicate that the selectivity of alpha-1 or alpha-2 receptor blockade in mice and rats can be reliably determined by using behavioral parameters.
Negative_regulation (blockade) of alpha-2 receptor
1) Confidence 0.54 Published 1984 Journal Pol J Pharmacol Pharm Section Abstract Doc Link 6152494 Disease Relevance 0 Pain Relevance 0.28
The alteration of [3H]clonidine binding was due to a decrease in alpha 2-adrenoceptor affinity, with no change in the density of binding sites, and was reversible in vitro upon repeated washing of the membrane preparation.
Negative_regulation (decrease) of 2-adrenoceptor associated with clonidine
2) Confidence 0.51 Published 1989 Journal Toxicol. Lett. Section Abstract Doc Link 2545016 Disease Relevance 0 Pain Relevance 0.34
These observations suggest that schizophrenia might be associated with abnormal noradrenergic function that is reflected by a decreased number of platelet alpha 2-adrenergic receptors.
Negative_regulation (decreased) of alpha 2-adrenergic in platelet associated with schizophrenia
3) Confidence 0.49 Published 1984 Journal Psychiatry Res Section Abstract Doc Link 6087398 Disease Relevance 0.25 Pain Relevance 0.22
The studies employed two genetically engineered mouse strains, having either a targeted inactivation of the alpha2C-AR gene (alpha2C-KO) or over-expressing the alpha2C-AR (alpha2C-OE).
Negative_regulation (inactivation) of alpha2C-AR associated with sprains and strains
4) Confidence 0.43 Published 2001 Journal Life Sci. Section Abstract Doc Link 11358337 Disease Relevance 0.43 Pain Relevance 0.17
The studies employed two genetically engineered mouse strains, having either a targeted inactivation of the alpha2C-AR gene (alpha2C-KO) or over-expressing the alpha2C-AR (alpha2C-OE).
Negative_regulation (inactivation) of alpha2C-AR associated with sprains and strains
5) Confidence 0.43 Published 2001 Journal Life Sci. Section Abstract Doc Link 11358337 Disease Relevance 0.44 Pain Relevance 0.18
The current study compared the antihyperalgesic efficacy of high (100 Hz) and low (4 Hz) frequency TENS in mutant mice lacking a functional alpha2A AR against their respective wildtype counterparts.
Negative_regulation (lacking) of alpha2A AR associated with antihyperalgesic and transcutaneous nerve stimulation
6) Confidence 0.42 Published 2005 Journal Pain Section Abstract Doc Link 15911163 Disease Relevance 0.09 Pain Relevance 1.12
The analgesic efficacy of partial opioid agonists is increased in mice with targeted inactivation of the alpha2A-adrenoceptor gene.
Negative_regulation (inactivation) of alpha2A associated with pain, mu agonist and analgesic
7) Confidence 0.42 Published 2006 Journal Eur. J. Pharmacol. Section Title Doc Link 16325800 Disease Relevance 0 Pain Relevance 1.40
Clonidine decreases rat urine kallikrein excretion by alpha-adrenergic receptor stimulation.
Negative_regulation (decreases) of alpha-adrenergic receptor in urine associated with clonidine
8) Confidence 0.41 Published 1982 Journal Eur. J. Pharmacol. Section Title Doc Link 6124432 Disease Relevance 0.18 Pain Relevance 0.45
In vBNST, the NE-induced decrease in synaptic transmission is markedly reduced in the alpha2A-AR knockout mouse.
Negative_regulation (reduced) of alpha2A-AR associated with targeted disruption
9) Confidence 0.40 Published 2005 Journal Neuropsychopharmacology Section Abstract Doc Link 15602500 Disease Relevance 0.20 Pain Relevance 0.13
In vBNST, the NE-induced decrease in synaptic transmission is markedly reduced in the alpha2A-AR knockout mouse.
Negative_regulation (reduced) of alpha2A-AR associated with targeted disruption
10) Confidence 0.40 Published 2005 Journal Neuropsychopharmacology Section Abstract Doc Link 15602500 Disease Relevance 0.20 Pain Relevance 0.13
Treatment with tricyclic antidepressant drugs led to significant decreases in the number of platelet alpha 2-adrenergic receptors.
Negative_regulation (decreases) of 2-adrenergic in platelet associated with tricyclic antidepressant
11) Confidence 0.33 Published 1981 Journal Arch. Gen. Psychiatry Section Abstract Doc Link 6274267 Disease Relevance 0.26 Pain Relevance 0.33
Mianserin is a tetracyclic antidepressant whose postulated mechanism of action involves release of noradrenaline mediated via cortical alpha 2-adrenergic autoreceptor blockade.
Negative_regulation (blockade) of 2-adrenergic associated with antidepressant and noradrenaline
12) Confidence 0.33 Published 1985 Journal Acta Psychiatr Scand Suppl Section Abstract Doc Link 2996305 Disease Relevance 0 Pain Relevance 0.39
Norepinephrine release during autoregulatory escape: effects of alpha 2-receptor blockade.
Negative_regulation (blockade) of alpha 2-receptor
13) Confidence 0.25 Published 1991 Journal Am. J. Physiol. Section Title Doc Link 1671736 Disease Relevance 0 Pain Relevance 0.07
The presence of functional alpha 2-receptors was demonstrated by clonidine injections, and the effects of alpha 2-receptor blockade were studied during yohimbine infusions.
Negative_regulation (blockade) of alpha 2-receptor associated with clonidine
14) Confidence 0.25 Published 1991 Journal Am. J. Physiol. Section Abstract Doc Link 1671736 Disease Relevance 0.05 Pain Relevance 0.10
The study demonstrated 1) that diminished NE release during continued sympathetic stimulation does not occur and cannot account for escape, 2) that resistance vessels in the canine intestinal circulation possess functional alpha 2-receptors which are responsible for part of the vasoconstriction caused by sympathetic stimulation, 3) that blockade of presynaptic alpha 2-receptors significantly enhanced NE release during the initial 30-s period but not during the escape phase, and 4) that alpha 2-receptor blockade enhances autoregulatory escape.
Negative_regulation (blockade) of alpha 2-receptor in vessels associated with increased venous pressure under development
15) Confidence 0.24 Published 1991 Journal Am. J. Physiol. Section Abstract Doc Link 1671736 Disease Relevance 0.10 Pain Relevance 0.07
PTX is known to interfere with the guanine nucleotide protein Gi that is required for opioid, alpha 2-adrenergic and muscarinic receptor-mediated inhibition of adenylate cyclase in various cells.
Negative_regulation (inhibition) of alpha 2-adrenergic associated with opioid
16) Confidence 0.17 Published 1987 Journal Brain Res. Section Abstract Doc Link 3545389 Disease Relevance 0.49 Pain Relevance 1.18
Autoradiographic studies with [125I]p-iodoclonidine in the presence of 10 microM epinephrine to block alpha 2-adrenergic sites or 100 nM moxonidine to mask I1-imidazoline sites show that both I1- as well as alpha 2-sites are localized in putative chemosensory areas of the rostral ventrolateral medulla in the cat.
Negative_regulation (block) of alpha 2-adrenergic in medulla associated with rostral ventrolateral medulla
17) Confidence 0.15 Published 1995 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7677359 Disease Relevance 0.34 Pain Relevance 0.26
Alpha 2-adrenergic receptor turnover in adipose tissue and kidney: irreversible blockade of alpha 2-adrenergic receptors by benextramine.
Negative_regulation (blockade) of alpha 2-adrenergic in kidney associated with obesity
18) Confidence 0.08 Published 1987 Journal Mol. Pharmacol. Section Title Doc Link 2880286 Disease Relevance 0.32 Pain Relevance 0.24
Alpha 2-adrenergic receptor turnover in adipose tissue and kidney: irreversible blockade of alpha 2-adrenergic receptors by benextramine.
Negative_regulation (blockade) of Alpha 2-adrenergic in kidney associated with obesity
19) Confidence 0.08 Published 1987 Journal Mol. Pharmacol. Section Title Doc Link 2880286 Disease Relevance 0.31 Pain Relevance 0.24
Thus, patients with downregulated alpha-2-receptor function during acute withdrawal after heavy alcohol intake showed similar subsensitive receptor function abnormality after a prolonged period of abstinence.
Negative_regulation (downregulated) of alpha-2-receptor associated with withdrawal and alcohol
20) Confidence 0.05 Published 2000 Journal Drug Alcohol Depend Section Abstract Doc Link 10661676 Disease Relevance 0.16 Pain Relevance 0.79

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