INT124560

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Context Info
Confidence 0.07
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.77
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Il1r1) plasma membrane (Il1r1) intracellular (Il1r1)
protein complex (Il1r1) signal transducer activity (Il1r1)
Anatomy Link Frequency
neurons 1
Il1r1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 12 100.00 Very High Very High Very High
dorsal root ganglion 2 98.80 Very High Very High Very High
Freund adjuvant 1 96.36 Very High Very High Very High
Inflammation 2 95.36 Very High Very High Very High
Hyperalgesia 1 94.84 High High
Pain 5 90.40 High High
cytokine 3 89.32 High High
Lasting pain 2 85.52 High High
Glutamate 2 80.64 Quite High
ketamine 94 79.28 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 2 98.32 Very High Very High Very High
INFLAMMATION 2 95.36 Very High Very High Very High
Hyperalgesia 1 94.84 High High
Pain 7 90.40 High High
Nervous System Injury 4 86.28 High High
Neuropathic Pain 80 61.52 Quite High
Sleep Disorders 3 5.00 Very Low Very Low Very Low
Nociception 3 5.00 Very Low Very Low Very Low
Vomiting 2 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of complete Freund's adjuvant on immunohistochemical distribution of IL-1beta and IL-1R I in neurons and glia cells of dorsal root ganglion.
Negative_regulation (distribution) of IL-1R I in neurons associated with ganglion cysts and dorsal root ganglion
1) Confidence 0.07 Published 2005 Journal Acta Pharmacol. Sin. Section Title Doc Link 15663898 Disease Relevance 0.29 Pain Relevance 0.28
Applying IL-1R antagonist and glial inhibitor, attenuates NMDAR phosphorylation [48].
Negative_regulation (inhibitor) of IL-1R associated with antagonist
2) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 0.49 Pain Relevance 0.86

General Comments

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