INT124606

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Context Info
Confidence 0.49
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 12.66
Pain Relevance 3.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mpo) extracellular space (Mpo) oxidoreductase activity (Mpo)
lysosome (Mpo)
Anatomy Link Frequency
neutrophils 5
bone marrow 4
macrophages 3
liver 2
peritoneal cavity 2
Mpo (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 73 100.00 Very High Very High Very High
methotrexate 9 99.36 Very High Very High Very High
Calcitonin gene-related peptide 6 98.60 Very High Very High Very High
Leflunomide 8 98.40 Very High Very High Very High
Paracetamol 15 98.32 Very High Very High Very High
Inflammation 305 97.64 Very High Very High Very High
qutenza 6 92.56 High High
substance P 4 89.92 High High
metalloproteinase 9 87.28 High High
antagonist 11 86.80 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 115 100.00 Very High Very High Very High
Cv Unclassified Under Development 77 100.00 Very High Very High Very High
Targeted Disruption 89 99.96 Very High Very High Very High
Infection 50 99.96 Very High Very High Very High
Injury 447 99.60 Very High Very High Very High
Toxicity 50 99.08 Very High Very High Very High
Melioidosis 57 98.14 Very High Very High Very High
INFLAMMATION 386 97.64 Very High Very High Very High
Reperfusion Injury 19 95.32 Very High Very High Very High
Coronary Artery Disease 11 95.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CGRP(8-37) or combination of SR 140333 and SR 48968 diminished neutrophil accumulation, MPO levels and IL-1beta production, airway hyperresponsiveness was inhibited only by SR 48968.
Positive_regulation (accumulation) of Gene_expression (production) of MPO in neutrophil associated with urological neuroanatomy and calcitonin gene-related peptide
1) Confidence 0.49 Published 2007 Journal Regul. Pept. Section Abstract Doc Link 17291600 Disease Relevance 0.61 Pain Relevance 1.04
Acetaminophen treatment caused a significant (P < 0.05-0.001) decrease in GSH levels whereas MDA levels and MPO activity were increased in both tissues.
Positive_regulation (increased) of Gene_expression (levels) of MPO associated with paracetamol and urological neuroanatomy
2) Confidence 0.48 Published 2005 Journal J Appl Toxicol Section Abstract Doc Link 15669031 Disease Relevance 0.23 Pain Relevance 0.70
At 24 hours of CLP, further increases of MPO levels were present in the peritoneal supernatants of both mice groups.
Positive_regulation (increases) of Gene_expression (levels) of MPO associated with urological neuroanatomy
3) Confidence 0.43 Published 2004 Journal BMC Clin Pathol Section Body Doc Link PMC503395 Disease Relevance 0.76 Pain Relevance 0
Although the MPO levels of the cell pellets indicated the presence of a significant number of neutrophils in the peritoneal cavity after CLP, the MPO values did not always correlate with the absolute number of infiltrated neutrophils.
Positive_regulation (after) of Gene_expression (levels) of MPO in peritoneal cavity associated with urological neuroanatomy
4) Confidence 0.43 Published 2004 Journal BMC Clin Pathol Section Body Doc Link PMC503395 Disease Relevance 0.48 Pain Relevance 0
Subsequent secondary activation of its metabolites by myeloperoxidase (MPO) present in bone marrow results in the production of genotoxic quinines and reactive oxygen species.
Positive_regulation (activation) of Gene_expression (present) of myeloperoxidase in bone marrow associated with urological neuroanatomy
5) Confidence 0.43 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688356 Disease Relevance 0.74 Pain Relevance 0
Subsequent secondary activation of its metabolites by myeloperoxidase (MPO) present in bone marrow results in the production of genotoxic quinines and reactive oxygen species.
Positive_regulation (activation) of Gene_expression (present) of MPO in bone marrow associated with urological neuroanatomy
6) Confidence 0.43 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688356 Disease Relevance 0.74 Pain Relevance 0
Slides were then incubated with a rabbit polyclonal antibody against myeloperoxidase (MPO) (1?
Positive_regulation (incubated) of Gene_expression (antibody) of MPO associated with urological neuroanatomy
7) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2756629 Disease Relevance 0.10 Pain Relevance 0
Slides were then incubated with a rabbit polyclonal antibody against myeloperoxidase (MPO) (1?
Positive_regulation (incubated) of Gene_expression (antibody) of myeloperoxidase associated with urological neuroanatomy
8) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2756629 Disease Relevance 0.10 Pain Relevance 0
The liver MPO levels of both wild-type and P/I null mice after 90 minutes of ischemia followed by 6 and 15 h of reperfusion were significantly elevated compared to the sham-operated mice at the corresponding time points.
Positive_regulation (elevated) of Gene_expression (levels) of MPO in liver associated with ischemia and urological neuroanatomy
9) Confidence 0.41 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1891280 Disease Relevance 1.04 Pain Relevance 0.30
Increase in MPO activity
Positive_regulation (Increase) of Gene_expression (activity) of MPO associated with urological neuroanatomy
10) Confidence 0.38 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2233982 Disease Relevance 0.52 Pain Relevance 0.47
In addition, simvastatin lowered MPO mRNA and enzyme activity even after 1 day in human MPO overexpressing transgenic mice fed drug for 1- 21 days [95].
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of MPO associated with targeted disruption and urological neuroanatomy
11) Confidence 0.34 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644496 Disease Relevance 0.92 Pain Relevance 0.17
Collectively the current evidence supports the need for further studies into the actual role of MPO, and whether elevated MPO levels in the serum directly correlates with MPO released from circulating neutrophils.


Spec (whether) Positive_regulation (elevated) of Gene_expression (levels) of MPO in neutrophils associated with urological neuroanatomy
12) Confidence 0.29 Published 2010 Journal BMC Med Section Body Doc Link PMC2898678 Disease Relevance 1.89 Pain Relevance 0.20
As neutrophils are the predominant infiltrating inflammatory cells during melioidosis [12], we also measured MPO in lungs from WT and OPN KO mice at 24 and 72 h after infection; MPO levels increased from 24 to 72 h in both groups.
Positive_regulation (increased) of Gene_expression (levels) of MPO in lungs associated with targeted disruption, inflammation, urological neuroanatomy, melioidosis and infection
13) Confidence 0.27 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2930856 Disease Relevance 2.61 Pain Relevance 0.29
Cisplatin-induced AKI is associated with increased renal myeloperoxidase, which is produced by neutrophils and macrophages [45, 108].
Positive_regulation (increased) of Gene_expression (produced) of myeloperoxidase in macrophages associated with injury
14) Confidence 0.14 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 0.96 Pain Relevance 0.03
Cisplatin-induced AKI is associated with increased renal myeloperoxidase, which is produced by neutrophils and macrophages [45, 108].
Positive_regulation (increased) of in neutrophils Gene_expression (produced) of myeloperoxidase in macrophages associated with injury
15) Confidence 0.05 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 0.96 Pain Relevance 0.03

General Comments

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