INT124614

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Context Info
Confidence 0.52
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.10
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ANPEP) cytosol (ANPEP) peptidase activity (ANPEP)
plasma membrane (ANPEP) cytoplasm (ANPEP)
Anatomy Link Frequency
bladder 1
prefrontal 1
ANPEP (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 5 100.00 Very High Very High Very High
addiction 3 98.20 Very High Very High Very High
Opioid 3 94.88 High High
Central nervous system 1 92.20 High High
superficial lamina 5 89.04 High High
Endogenous opioid 1 88.56 High High
Morphine 1 47.20 Quite Low
anesthesia 2 5.00 Very Low Very Low Very Low
neuralgia 1 5.00 Very Low Very Low Very Low
Dismenorea 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pyelonephritis 30 100.00 Very High Very High Very High
Drug Dependence 1 98.20 Very High Very High Very High
Urinary Tract Infection 32 61.84 Quite High
Viral Infection 2 41.52 Quite Low
Bacterial Respiratory Disease 4 36.40 Quite Low
Cancer 33 5.00 Very Low Very Low Very Low
Infection 27 5.00 Very Low Very Low Very Low
Sprains And Strains 17 5.00 Very Low Very Low Very Low
Disease 17 5.00 Very Low Very Low Very Low
Abscess 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we have analyzed the activity of two enkephalin-degrading enzymes (puromycin-sensitive aminopeptidase or PSA and aminopeptidase N or APN) and two functionally different, soluble aminopeptidases (aminopeptidase B and aspartyl-aminopeptidase) in postmortem samples of prefrontal cortex and caudate nucleus of eight human heroin addict brains and eight matched-controls.
Spec (analyzed) Transcription (activity) of APN in prefrontal associated with enkephalin
1) Confidence 0.52 Published 2005 Journal Neurochem. Int. Section Abstract Doc Link 15670637 Disease Relevance 0.10 Pain Relevance 0.46
CD phenotyping of the resultant cultures showed previously that the prostate and bladder cells could be distinguished (e.g., reactivity to CD56) but a number of CD molecules, among them CD13, were also expressed as a result of cell culture [8].
Transcription (expressed) of CD13 in bladder
2) Confidence 0.42 Published 2005 Journal BMC Urol Section Body Doc Link PMC1327674 Disease Relevance 0 Pain Relevance 0.04
DPPH free radical scavenging activity of PEPN
Transcription (activity) of PEPN
3) Confidence 0.22 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792611 Disease Relevance 0 Pain Relevance 0
Transcriptional activity from the APN promoter (A-C) was about 50% lower compared to the ABU (A-T) promoter (Figure 6C).
Transcription (activity) of APN promoter associated with pyelonephritis
4) Confidence 0.07 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2944801 Disease Relevance 1.01 Pain Relevance 0

General Comments

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