INT12464

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Context Info
Confidence 0.47
First Reported 1983
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 38
Total Number 40
Disease Relevance 10.30
Pain Relevance 13.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (MET) signal transduction (MET) plasma membrane (MET)
Anatomy Link Frequency
HGF 2
germline 2
plasma 1
Brain 1
internal 1
MET (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 170 100.00 Very High Very High Very High
substance P 94 100.00 Very High Very High Very High
Ultiva 64 100.00 Very High Very High Very High
Enkephalin 63 100.00 Very High Very High Very High
opiate 22 100.00 Very High Very High Very High
Pain 400 99.76 Very High Very High Very High
Catechol-O-methyltransferase 157 98.84 Very High Very High Very High
antagonist 43 98.52 Very High Very High Very High
anesthesia 15 97.36 Very High Very High Very High
Limbic system 4 97.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 383 99.96 Very High Very High Very High
Pain 404 99.76 Very High Very High Very High
Generaliased Trisomy 2 99.40 Very High Very High Very High
Anaplastic Astrocytoma 4 98.32 Very High Very High Very High
Chromosome Aberrations 1 97.80 Very High Very High Very High
Obesity 11 97.48 Very High Very High Very High
Hyperplasia 5 94.48 High High
Sprains And Strains 9 94.12 High High
Metastasis 73 94.00 High High
Hyperalgesia 36 93.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The second type of receptors interacted with 125I-beta-endorphin, 3H-Met-enkephalin, 3H-Leu-enkephalin and 3H-morphin; the first displayed reactivity with 125I-beta-endorphin, 3H-morphin and immunorphin.
Met Binding (interacted) of associated with enkephalin
1) Confidence 0.47 Published 1996 Journal Immunol. Lett. Section Abstract Doc Link 8964604 Disease Relevance 0 Pain Relevance 0.24
This hypothesis is confirmed by "in vitro" studies demonstrating that salsolinol displaces 3H-Met-enkephalin and 3H-DHM but not 3H-DADLE binding.
Met Binding (binding) of associated with enkephalin
2) Confidence 0.47 Published 1985 Journal Alcohol Section Abstract Doc Link 2990502 Disease Relevance 0 Pain Relevance 0.86
On the other hand, Kd values for 3H-Met-enkephalin and 3H-DHM (mu-opiate receptors) specific binding are enhanced.
Met Binding (binding) of associated with opiate and enkephalin
3) Confidence 0.47 Published 1985 Journal Alcohol Section Abstract Doc Link 2990502 Disease Relevance 0 Pain Relevance 0.90
It has been hypothesized that the decrease of 3H-Met-enkephalin and 3H-DHM affinity for their receptors takes place because endogenous substances from ethanol metabolism (for example salsolinol) behave as mu opioid agonists.
Met Binding (affinity) of associated with mu agonist and enkephalin
4) Confidence 0.47 Published 1985 Journal Alcohol Section Abstract Doc Link 2990502 Disease Relevance 0 Pain Relevance 0.91
[The content of beta-endorphin, met-enkephalin and ACTH in the blood plasma during electric and drug anesthesia].
met Binding (content) of in blood associated with anesthesia and enkephalin
5) Confidence 0.36 Published 1996 Journal Anesteziol Reanimatol Section Title Doc Link 8967632 Disease Relevance 0 Pain Relevance 0.33
The Met/Met genotype was associated with a marked increase of 1.5 log units in the lipolytic sensitivity to the beta2-adrenoceptor agonist terbutaline (P=0.0008) as compared with the Thr/Thr and Thr/Met genotypes.
Met Binding (associated) of associated with agonist
6) Confidence 0.36 Published 2005 Journal J. Lipid Res. Section Abstract Doc Link 16024912 Disease Relevance 0.27 Pain Relevance 0.17
The Met/Met genotype of the common single-nucleotide polymorphism (SNP), rs4917, in the AHSG gene has been shown to be associated with reduced plasma levels as well as lower body fat.
Met Binding (associated) of in plasma
7) Confidence 0.36 Published 2005 Journal J. Lipid Res. Section Abstract Doc Link 16024912 Disease Relevance 0.17 Pain Relevance 0.03
Incubation of [3H]-tyrosine methionine5-enkephalin (MET) with human brain preparations (100,000g supernatant; sections of the limbic system, thalamus, basal ganglia, cerebellum, and cortex) results in its rapid and complete degradation; over 95% of the initial labeled tyrosine is recovered as the free aminoacid within 10 min.
MET Binding (Incubation) of in thalamus associated with thalamus, enkephalin and limbic system
8) Confidence 0.36 Published 2008 Journal Neurochem. Res. Section Abstract Doc Link 17676390 Disease Relevance 0 Pain Relevance 0.37
The HGF/c-Met interaction plays a pivotal role in cancer invasion that is mediated by the tumor stromal cell production of HGF [52], which can induce ECM degradation, tubule formation and angiogenesis [53].
c-Met Binding (interaction) of in HGF associated with cancer
9) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 0.57 Pain Relevance 0
The interaction of 3,5-pyrazolidinedione drugs with receptors for f-Met-Leu-Phe on human neutrophil leukocytes: a study of the structure-activity relationship.
Met Binding (interaction) of in neutrophil leukocytes
10) Confidence 0.36 Published 1991 Journal Can. J. Physiol. Pharmacol. Section Title Doc Link 1647850 Disease Relevance 0 Pain Relevance 0.14
Eukaryotic cell polypeptide chain initiation factor eIF-2 forms ternary complexes with GTP and initiator Met-tRNAf.
Met Binding (complexes) of in Eukaryotic cell
11) Confidence 0.36 Published 1983 Journal Biochemistry Section Abstract Doc Link 6551177 Disease Relevance 0.07 Pain Relevance 0
The results indicate that the mode of binding of Tyr-1, but not of residue 27, is similar in the two endorphins and differs from that of Tyr-1 in [Met]enkephalin.
Met Neg (not) Binding (binding) of associated with enkephalin
12) Confidence 0.36 Published 1983 Journal Eur. J. Biochem. Section Abstract Doc Link 6307694 Disease Relevance 0 Pain Relevance 0.19
Increased reactivity for vasoactive intestinal polypeptide, opioid peptides leu-enkephalin and met-enkephalin, and substance P was present in all cases with transmural involvement; mucosal GN showed normal reactivity for opioid peptides and focal increased staining for substance P (one case) and vasoactive intestinal polypeptide (two cases) in the lamina propria.
met Binding (reactivity) of in lamina associated with enkephalin, opioid and substance p
13) Confidence 0.36 Published 1991 Journal Hum. Pathol. Section Abstract Doc Link 1706307 Disease Relevance 0.67 Pain Relevance 0.52
Of the proto-oncogenes only the c-met gene which encodes for a transmembrane tyrosine kinase has been shown to be associated with the development of cartilaginous tumors [13].
c-met Binding (associated) of associated with cancer
14) Confidence 0.35 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1634757 Disease Relevance 1.95 Pain Relevance 0.06
[Leu]-enkephalin and its analogues displayed a combination of internal and external binding like [Met]-enkephalin in its secondary subsite.
Met Binding (binding) of in external associated with enkephalin
15) Confidence 0.35 Published 1987 Journal Mol. Immunol. Section Abstract Doc Link 3116411 Disease Relevance 0 Pain Relevance 0.59
Brain Met- and Leu-enk levels were investigated with radioimmunoassay and their binding to enkephalin receptors was studied with [3H]Met- and [3H]Leu-enkephalin in 56 human subjects (4-93 yr).
Met Binding (binding) of in Brain associated with enkephalin
16) Confidence 0.31 Published 1993 Journal Brain Res. Section Abstract Doc Link 8252385 Disease Relevance 0.14 Pain Relevance 0.48
To explore the main effects and a possible interaction for the three provocations in the post Remifentanil period a repeated measures ANOVA was perfomed for T3–T5 (between subjects factor was COMTval158met genotype, within subjects factor was the three different timepoints).
COMTval158met Spec (possible) Binding (interaction) of associated with ultiva
17) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695541 Disease Relevance 0.43 Pain Relevance 0.83
For genotyping of COMTval158met (rs4680) a commercial TaqMan® assay was used.
COMTval158met Binding (genotyping) of
18) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695541 Disease Relevance 0.28 Pain Relevance 0.43
The COMTval158met polymorphism is a key regulator of dopaminergic neurotransmission and has consistently been associated with human prefrontal function.
COMTval158met Binding (associated) of in prefrontal
19) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695541 Disease Relevance 0.97 Pain Relevance 1.76
Most of the germline mutations occur within the MET
MET Binding (occur) of in germline
20) Confidence 0.25 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 0.40 Pain Relevance 0

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