INT124669

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Context Info
Confidence 0.75
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.66
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grik2) plasma membrane (Grik2)
Anatomy Link Frequency
SH-SY5Y 2
neuronal 1
Grik2 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 15 100.00 Very High Very High Very High
IPN 2 99.28 Very High Very High Very High
qutenza 2 98.86 Very High Very High Very High
Spinal cord 1 98.44 Very High Very High Very High
Hippocampus 27 97.48 Very High Very High Very High
Lasting pain 3 95.40 Very High Very High Very High
Glutamate 125 94.04 High High
amygdala 121 80.72 Quite High
Root ganglion neuron 1 80.64 Quite High
Pyramidal cell 26 71.16 Quite High
Disease Link Frequency Relevance Heat
Inflammatory Pain 2 99.28 Very High Very High Very High
Anxiety Disorder 56 98.24 Very High Very High Very High
Pain 4 95.40 Very High Very High Very High
Targeted Disruption 91 83.36 Quite High
Ganglion Cysts 1 80.24 Quite High
Nervous System Malformation 8 79.76 Quite High
Panic Disorder 1 63.72 Quite High
Aids-related Complex 3 50.32 Quite High
Schizophrenia 13 50.00 Quite Low
Death 10 37.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: Xe blocks not only NMDA receptors, but also AMPA and kainate receptors in cortical neurones as well as GluR6-type receptors expressed in SH-SY5Y cells.
Gene_expression (expressed) of GluR6 in SH-SY5Y
1) Confidence 0.75 Published 2005 Journal Br J Anaesth Section Body Doc Link 15695547 Disease Relevance 0 Pain Relevance 0
METHODS: The study was performed on voltage-clamped cortical neurones from embryonic mice and SH-SY5Y cells expressing GluR6 kainate receptors.
Gene_expression (expressing) of GluR6 in SH-SY5Y
2) Confidence 0.75 Published 2005 Journal Br J Anaesth Section Body Doc Link 15695547 Disease Relevance 0 Pain Relevance 0
The overall influence that the small changes in expression of Gria's, Grm's and Grik2 may have on synaptic activity and neuronal integrity would be difficult to predict.
Gene_expression (expression) of Grik2 in neuronal
3) Confidence 0.73 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.34 Pain Relevance 0.36
Here we show that responses to capsaicin or inflammatory pain were significantly reduced in mice lacking glutamate receptor 5 (GluR5) but not GluR6 subunits.
Neg (lacking) Gene_expression (lacking) of GluR6 associated with qutenza, glutamate receptor and ipn
4) Confidence 0.51 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15673679 Disease Relevance 0.77 Pain Relevance 0.55
The KA receptor family is composed of five different subunits, namely GluR5, GluR6, GluR7, KA1 and KA2, which can form a variety of homomeric and heteromeric receptors [21].
Gene_expression (composed) of GluR6
5) Confidence 0.36 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1766473 Disease Relevance 0.55 Pain Relevance 0.52
Also, we observed that the two-step procedure unmasked core interacting proteins that were not detected by mass spectrometry in the single-step purification: Ten known PSD-95 interactors, Begain, Cit, Grik2, Grik5, Grin2c, Kcna4, Lrp1, Nlgn2, Nlgn3 and Shank1, were present only after the tandem purification.
Gene_expression (present) of Grik2
6) Confidence 0.36 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2694677 Disease Relevance 0 Pain Relevance 0.03

General Comments

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