INT124743

Context Info Confidence 0.03 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.15 Pain Relevance 0.85

plasma membrane (ARSA, PTGER2) small molecule metabolic process (ARSA) signal transducer activity (PTGER2) lysosome (ARSA)

Anatomy Link Frequency PGE2 1 ARSA (Homo sapiens) PTGER2 (Homo sapiens)

Pain Link Frequency Relevance Heat aspirin 6 100.00 cINOD 9 90.08 cytokine 1 88.72 rheumatoid arthritis 1 76.40 COX2 1 25.00

Disease Link Frequency Relevance Heat Rheumatoid Arthritis 1 76.40 INFLAMMATION 1 73.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Unlike acetylsalicylic acid (ASA), NO-ASA reduces the levels of PGE2, without increasing GM-CSF release, although cell viability is reduced at the highest concentration (1 mM).

NO-ASA Negative_regulation (reduces) of PGE2 in PGE2 associated with aspirin

1) Confidence 0.03 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15680249 Disease Relevance 0.15 Pain Relevance 0.85

General Comments

This test has worked.