INT124760

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Context Info
Confidence 0.69
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 11
Disease Relevance 2.58
Pain Relevance 2.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Kcnn1) cytoplasm (Kcnn1)
Anatomy Link Frequency
microglia 3
nervous system 2
bar 1
neurons 1
spinal cord 1
Kcnn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 16 99.52 Very High Very High Very High
Eae 2 99.12 Very High Very High Very High
cva 88 98.80 Very High Very High Very High
Arthritis 2 97.04 Very High Very High Very High
Action potential 17 96.88 Very High Very High Very High
Inflammation 74 95.28 Very High Very High Very High
Neuronal excitability 8 91.28 High High
monoamine 1 87.04 High High
nociceptor 4 86.96 High High
Serotonin 1 83.52 Quite High
Disease Link Frequency Relevance Heat
Injury 26 99.12 Very High Very High Very High
Hemorrhage 8 98.80 Very High Very High Very High
Nervous System Injury 2 97.96 Very High Very High Very High
Arthritis 2 97.04 Very High Very High Very High
INFLAMMATION 82 95.28 Very High Very High Very High
Stroke 168 92.12 High High
Nociception 4 86.80 High High
Apoptosis 48 81.68 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 8 68.08 Quite High
Drug Induced Neurotoxicity 40 56.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We show that SK1, SK2, SK3 and IK1 are all expressed in DRG and spinal cord.
Gene_expression (expressed) of SK1 in spinal cord associated with spinal cord
1) Confidence 0.69 Published 2005 Journal Neuroscience Section Abstract Doc Link 15680700 Disease Relevance 0.55 Pain Relevance 0.59
There are three mammalian SK channels (KCNN1/SK1, KCNN2/SK2, KCNN3/SK3), which are predominantly expressed in the nervous system.
Gene_expression (expressed) of SK1 in nervous system
2) Confidence 0.67 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819255 Disease Relevance 0.18 Pain Relevance 0.27
First, we compared transcript expression of KCNN1, KCNN2 and KCNN3 in microglia isolated from rat brain.
Gene_expression (expression) of KCNN1 in brain
3) Confidence 0.67 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819255 Disease Relevance 0.13 Pain Relevance 0.18
(i) Transcripts for all three cloned SK channels (KCNN1, KCNN2, KCNN3) are expressed in microglia, but KCNN3 predominates and is the only channel up-regulated in LPS-activated microglia.
Gene_expression (expressed) of KCNN1 in microglia
4) Confidence 0.67 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819255 Disease Relevance 0.26 Pain Relevance 0.12
The family of calcium-activated slow-potassium (SK) channels comprises 3 members, the SK1, SK2 and SK3 channels, all expressed in neurons, known to mediate the slow-afterhyperpolarization occurring after action potentials.
Gene_expression (expressed) of SK1 in neurons associated with action potential
5) Confidence 0.58 Published 2009 Journal Brain Res. Section Abstract Doc Link 19446538 Disease Relevance 0 Pain Relevance 0.32
(i) Transcripts for all three cloned SK channels (KCNN1, KCNN2, KCNN3) are expressed in microglia, but KCNN3 predominates and is the only channel up-regulated in LPS-activated microglia.
Gene_expression (expressed) of KCNN1 in microglia
6) Confidence 0.58 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819255 Disease Relevance 0.26 Pain Relevance 0.12
(iv) SK3 channels (but not SK1 or SK2) contributed to microglial activation, which up-regulated iNOS and NO production, and involved a functional link to signaling through p38 MAP kinase.
Gene_expression (channels) of SK1
7) Confidence 0.58 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819255 Disease Relevance 0.47 Pain Relevance 0.12
Expression of KCNN/SK channels in microglia

[For all quantitative data, statistical analyses and levels of significance are shown on the bar graphs.]

Gene_expression (Expression) of KCNN in bar
8) Confidence 0.52 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819255 Disease Relevance 0 Pain Relevance 0
There are three mammalian SK channels (KCNN1/SK1, KCNN2/SK2, KCNN3/SK3), which are predominantly expressed in the nervous system.
Gene_expression (expressed) of KCNN1 in nervous system
9) Confidence 0.52 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819255 Disease Relevance 0.19 Pain Relevance 0.27
Figure 1A shows transcript expression of three KCNN channels in cultured microglia.
Gene_expression (expression) of KCNN in microglia
10) Confidence 0.45 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819255 Disease Relevance 0 Pain Relevance 0
We show that SK1, SK2, SK3 and IK1 are all expressed in DRG and spinal cord.
Gene_expression (expressed) of SK1 in DRG associated with spinal cord
11) Confidence 0.24 Published 2005 Journal Neuroscience Section Abstract Doc Link 15680700 Disease Relevance 0.55 Pain Relevance 0.59

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