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Context Info
Confidence 0.44
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 5.25
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (NCAM1) cell adhesion (NCAM1) plasma membrane (NCAM1)
Anatomy Link Frequency
NK cells 2
neural 2
perineuronal satellite cells 1
lymphocytes 1
appendix 1
NCAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 24 99.62 Very High Very High Very High
cytokine 21 98.04 Very High Very High Very High
GABAergic 1 91.92 High High
abdominal pain 6 91.44 High High
trigeminal ganglion 15 83.84 Quite High
imagery 3 83.40 Quite High
headache 4 81.92 Quite High
Inflammatory response 2 81.80 Quite High
Pain 4 75.60 Quite High
tolerance 11 75.00 Quite High
Disease Link Frequency Relevance Heat
Epstein-barr Virus 13 99.80 Very High Very High Very High
Cancer 20 99.40 Very High Very High Very High
Ganglion Cysts 20 99.12 Very High Very High Very High
Injury 2 98.24 Very High Very High Very High
Autism 2 97.44 Very High Very High Very High
Thrombosis Related Under Development 1 94.80 High High
Duodenal Ulcer 3 93.92 High High
Gallbladder Disease 5 92.64 High High
Abdominal Pain 6 91.44 High High
Melena 1 89.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since no significant changes were observed in the number of CD56dimCD16+ NK cells between groups, it is likely that poor chemokine receptor function affected the CD56brightCD16- NK migration to the periphery.
Regulation (affected) of CD56 in NK cells associated with chemokine
1) Confidence 0.44 Published 2010 Journal J Transl Med Section Body Doc Link PMC2829521 Disease Relevance 0.40 Pain Relevance 0.40
For example, alterations in RNA expression levels for CD56brightCD16- NK receptors has been demonstrated in patients with Autism Spectrum Disorder where cytotoxic activity and NK cell numbers were also decreased when NK cells were stimulated by a pathogen [53].
Regulation (alterations) of CD56 in NK cells associated with autism
2) Confidence 0.44 Published 2010 Journal J Transl Med Section Body Doc Link PMC2829521 Disease Relevance 0.72 Pain Relevance 0.20
Pathologic examination revealed the diffuse infiltration of atypical lymphocytes with an angiocentric growth pattern, which was positive for CD3, CD56, and granzyme.
Regulation (positive) of CD56 in lymphocytes
3) Confidence 0.41 Published 2009 Journal Korean J Gastroenterol Section Abstract Doc Link 19844154 Disease Relevance 1.07 Pain Relevance 0.09
The tumor cells that reacted to antibodies directed against HepPar1, CAM 5.2, CK19 and scattered cells were immunoreactive for CD117, CD34, and CD56.
Regulation (immunoreactive) of CD56 associated with cancer
4) Confidence 0.39 Published 2005 Journal Mod. Pathol. Section Abstract Doc Link 15696116 Disease Relevance 0.68 Pain Relevance 0.08
Moreover, changes in PSA-NCAM in the avian ciliary ganglion after axonal injury also involve perineuronal satellite cells [60].
Regulation (changes) of PSA-NCAM in perineuronal satellite cells associated with ganglion cysts and injury
5) Confidence 0.22 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2612005 Disease Relevance 0.28 Pain Relevance 0.17
Moreover the immunolabelling for synaptophysin, neurofilaments, Olig2 and NCAM was present in the peripheral part of the lesion.
Regulation (immunolabelling) of NCAM
6) Confidence 0.20 Published 2008 Journal Folia Neuropathol Section Abstract Doc Link 18587711 Disease Relevance 0.88 Pain Relevance 0.12
The level of CD3, CD56, CD25, and CD69 antigen immunoreactivity was assessed by immunohistochemistry in 26 decidual tissue samples.
Regulation (immunoreactivity) of CD56
7) Confidence 0.11 Published 2007 Journal Clinical and Developmental Immunology Section Abstract Doc Link PMC2246050 Disease Relevance 0.07 Pain Relevance 0.04
Pathology of the appendix showed large cells positive for CD3, CD56 and Epstein Barr Virus-encoded RNA staining, and negative for CD20 and CD30.
Regulation (positive) of CD56 in appendix associated with epstein-barr virus
8) Confidence 0.07 Published 2011 Journal J Med Case Reports Section Abstract Doc Link PMC3024289 Disease Relevance 1.13 Pain Relevance 0.13
METHODS: The effects of the anti-neural-cell-adhesion molecule (anti-NCAM) were assessed on cold water swim stress-induced antinociception in Wistar rats with Freund's adjuvant-induced inflammation of one hindpaw.
Regulation (effects) of anti-neural-cell-adhesion molecule in neural
9) Confidence 0.04 Published 2006 Journal Anesth. Analg. Section Body Doc Link 17122239 Disease Relevance 0 Pain Relevance 0
To characterize the extent to which rosette cells can differentiate into all three neural cell lineages, we used immunocytochemical analysis of cells cultured on PDL/laminin substrates with a panel of antibodies and demonstrated that hESC-derived neural derivatives sequentially expressed Sox1, nestin, musashi (not shown), A2B5 and PS-NCAM, followed by TuJ1 expression in many cells in first 1–5 days postplating on PDL/laminin substrates.
Regulation (followed) of PS-NCAM in neural
10) Confidence 0.01 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570688 Disease Relevance 0 Pain Relevance 0.05

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