INT125006

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Context Info
Confidence 0.05
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 3.38
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (DEFA5) extracellular region (DEFA5)
Anatomy Link Frequency
Paneth cells 2
leukocyte 1
DEFA5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Crohn's disease 100 97.28 Very High Very High Very High
Inflammation 135 90.48 High High
Bile 30 74.88 Quite High
Inflammatory response 10 53.60 Quite High
peptic ulcer disease 1 50.00 Quite Low
Potency 5 7.12 Low Low
cytokine 15 5.00 Very Low Very Low Very Low
chemokine 15 5.00 Very Low Very Low Very Low
corticosteroid 5 5.00 Very Low Very Low Very Low
Inflammatory mediators 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bacterial Respiratory Disease 35 99.72 Very High Very High Very High
Disease 141 97.28 Very High Very High Very High
Metaplasia 15 97.20 Very High Very High Very High
Infection 55 95.04 Very High Very High Very High
Targeted Disruption 30 93.76 High High
Gastritis 20 92.32 High High
INFLAMMATION 115 90.48 High High
Colitis 10 90.00 High High
Gallstones 10 82.72 Quite High
Infertility 5 65.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HD-5 in the ileostomy fluid of Crohn's patients is predominantly present in complexes with trypsin or chymotrypsin, suggesting an additional way by which epithelial defense might be compromised in CD.
Gene_expression (present) of HD-5
1) Confidence 0.05 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2992817 Disease Relevance 0.40 Pain Relevance 0.11
Interestingly, expression of HD-5 exceeds expression levels of other AMPs produced by the Paneth cell (lysozyme and sPLa2) by a factor up to 100 [45].
Gene_expression (expression) of HD-5 in Paneth cell
2) Confidence 0.05 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2992817 Disease Relevance 0.33 Pain Relevance 0.10
Interesting in this context is the fact that S. typhimurium can downregulate HD-5 expression via a type-3 secretion system (see Figure 1).
Gene_expression (expression) of HD-5
3) Confidence 0.05 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2992817 Disease Relevance 0.58 Pain Relevance 0
A high HD-5 expression has been observed by Shen et al. [37], suggesting that in intestinal metaplasia, where ?
Gene_expression (expression) of HD-5 associated with metaplasia
4) Confidence 0.04 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2992817 Disease Relevance 1.03 Pain Relevance 0.06
-defensin producing Paneth cells are present, this metaplastic change may strengthen the antibacterial response via production of HD-5.
Gene_expression (production) of HD-5 in Paneth cells associated with bacterial respiratory disease
5) Confidence 0.04 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2992817 Disease Relevance 1.04 Pain Relevance 0.11
METHODS: We assessed the expression of epithelial secretory leukocyte protease inhibitor, human beta-defensins (HBD1 and HBD2), and alpha-defensin (HD5) in gastric biopsies taken from 52 patients, median age of 55 years.
Gene_expression (expression) of alpha-defensin in leukocyte
6) Confidence 0.04 Published 2005 Journal Dig Liver Dis Section Body Doc Link 15702860 Disease Relevance 0 Pain Relevance 0

General Comments

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